Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines A Nakamura, M Nakajima, H Yamanaka, R Fujiwara, T Yokoi Drug Metabolism and Disposition 36 (8), 1461-1464, 2008 | 344 | 2008 |
Quantitative analysis of UDP-glucuronosyltransferase (UGT) 1A and UGT2B expression levels in human livers T Izukawa, M Nakajima, R Fujiwara, H Yamanaka, T Fukami, M Takamiya, ... Drug Metabolism and Disposition 37 (8), 1759-1768, 2009 | 281 | 2009 |
Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus R Fujiwara, N Nguyen, S Chen, RH Tukey Proceedings of the National Academy of Sciences 107 (11), 5024-5029, 2010 | 123 | 2010 |
Systemic regulation of bilirubin homeostasis: potential benefits of hyperbilirubinemia R Fujiwara, M Haag, E Schaeffeler, AT Nies, UM Zanger, M Schwab Hepatology 67 (4), 1609-1619, 2018 | 109 | 2018 |
Interactions between human UGT1A1, UGT1A4, and UGT1A6 affect their enzymatic activities R Fujiwara, M Nakajima, H Yamanaka, M Katoh, T Yokoi Drug metabolism and disposition 35 (10), 1781-1787, 2007 | 91 | 2007 |
Effects of coexpression of UGT1A9 on enzymatic activities of human UGT1A isoforms R Fujiwara, M Nakajima, H Yamanaka, A Nakamura, M Katoh, S Ikushiro, ... Drug metabolism and disposition 35 (5), 747-757, 2007 | 87 | 2007 |
Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia R Fujiwara, S Chen, M Karin, RH Tukey Gastroenterology 142 (1), 109-118. e2, 2012 | 69 | 2012 |
Species differences in drug glucuronidation: Humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in … R Fujiwara, E Yoda, RH Tukey Drug metabolism and pharmacokinetics 33 (1), 9-16, 2018 | 68 | 2018 |
Structure and protein–protein interactions of human UDP-glucuronosyltransferases R Fujiwara, T Yokoi, M Nakajima Frontiers in pharmacology 7, 225472, 2016 | 66 | 2016 |
Role of extrahepatic UDP-glucuronosyltransferase 1A1: advances in understanding breast milk-induced neonatal hyperbilirubinemia R Fujiwara, Y Maruo, S Chen, RH Tukey Toxicology and applied pharmacology 289 (1), 124-132, 2015 | 65 | 2015 |
Interactions between human UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A enzymes R Fujiwara, M Nakajima, S Oda, H Yamanaka, S Ikushiro, T Sakaki, ... Journal of pharmaceutical sciences 99 (1), 442-454, 2010 | 63 | 2010 |
N-Glycosylation plays a role in protein folding of human UGT1A9 M Nakajima, T Koga, H Sakai, H Yamanaka, R Fujiwara, T Yokoi Biochemical pharmacology 79 (8), 1165-1172, 2010 | 55 | 2010 |
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase … T Koga, R Fujiwara, M Nakajima, T Yokoi Drug metabolism and disposition 39 (1), 54-60, 2011 | 54 | 2011 |
Inhibition of adenosine deaminase (ADA)‐mediated metabolism of cordycepin by natural substances G Li, I Nakagome, S Hirono, T Itoh, R Fujiwara Pharmacology research & perspectives 3 (2), e00121, 2015 | 52 | 2015 |
Product inhibition of UDP-glucuronosyltransferase (UGT) enzymes by UDP obfuscates the inhibitory effects of UGT substrates R Fujiwara, M Nakajima, H Yamanaka, M Katoh, T Yokoi Drug metabolism and disposition 36 (2), 361-367, 2008 | 50 | 2008 |
Importance of UDP-glucuronosyltransferase 1A1 expression in skin and its induction by UVB in neonatal hyperbilirubinemia K Sumida, M Kawana, E Kouno, T Itoh, S Takano, T Narawa, RH Tukey, ... Molecular pharmacology 84 (5), 679-686, 2013 | 48 | 2013 |
Stereoselective glucuronidation of 5-(4′-hydroxyphenyl)-5-phenylhydantoin by human UDP-glucuronosyltransferase (UGT) 1A1, UGT1A9, and UGT2B15: effects of UGT-UGT interactions M Nakajima, H Yamanaka, R Fujiwara, M Katoh, T Yokoi Drug metabolism and disposition 35 (9), 1679-1686, 2007 | 45 | 2007 |
Impact of fatty acids on human UDP-glucuronosyltransferase 1A1 activity and its expression in neonatal hyperbilirubinemia A Shibuya, T Itoh, RH Tukey, R Fujiwara Scientific reports 3 (1), 2903, 2013 | 41 | 2013 |
Expression of human solute carrier family transporters in skin: possible contributor to drug-induced skin disorders R Fujiwara, S Takenaka, M Hashimoto, T Narawa, T Itoh Scientific reports 4 (1), 5251, 2014 | 40 | 2014 |
Expression pattern of human ATP‐binding cassette transporters in skin S Takenaka, T Itoh, R Fujiwara Pharmacology research & perspectives 1 (1), 2013 | 38 | 2013 |