| Multiple-component condensation strategies for combinatorial library synthesis RW Armstrong, AP Combs, PA Tempest, SD Brown, TA Keating Accounts of Chemical Research 29 (3), 123-131, 1996 | 1525 | 1996 |
| Recent advances in heterocycle generation using the efficient Ugi multiple-component condensation reaction. PA Tempest Current opinion in drug discovery & development 8 (6), 776-788, 2005 | 174 | 2005 |
| Use of a convertible isocyanide for generation of Ugi reaction derivatives on solid support: Synthesis of α-acylaminoesters and pyrroles AM Strocker, TA Keating, PA Tempest, RW Armstrong Tetrahedron letters 37 (8), 1149-1152, 1996 | 132 | 1996 |
| Two-step solution-phase synthesis of novel benzimidazoles utilizing a UDC (Ugi/de-Boc/cyclize) strategy P Tempest, V Ma, S Thomas, Z Hua, MG Kelly, C Hulme Tetrahedron Letters 42 (30), 4959-4962, 2001 | 127 | 2001 |
| Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607 Y Shi, AG Murzin, B Falcon, A Epstein, J Machin, P Tempest, KL Newell, ... Acta neuropathologica 141, 697-708, 2021 | 123 | 2021 |
| Evolution of a highly selective and potent 2-(pyridin-2-yl)-1, 3, 5-triazine Tie-2 kinase inhibitor BL Hodous, SD Geuns-Meyer, PE Hughes, BK Albrecht, S Bellon, ... Journal of medicinal chemistry 50 (4), 611-626, 2007 | 117 | 2007 |
| Fenchylamine sulfonamide inhibitors of amyloid β peptide production by the γ-secretase proteolytic pathway: potential small-molecule therapeutic agents for the treatment of … GM Rishton, DM Retz, PA Tempest, J Novotny, S Kahn, JJS Treanor, ... Journal of medicinal chemistry 43 (12), 2297-2299, 2000 | 108 | 2000 |
| Cyclobutenedione derivatives on solid support: Toward multiple core structure libraries PA Tempest, RW Armstrong Journal of the American Chemical Society 119 (32), 7607-7608, 1997 | 107 | 1997 |
| Two-step solution-phase synthesis of novel quinoxalinones utilizing a UDC (Ugi/de-Boc/cyclize) strategy T Nixey, P Tempest, C Hulme Tetrahedron letters 43 (9), 1637-1639, 2002 | 104 | 2002 |
| MCC/SNAr methodology. Part 1: Novel access to a range of heterocyclic cores P Tempest, V Ma, MG Kelly, W Jones, C Hulme Tetrahedron Letters 42 (30), 4963-4968, 2001 | 104 | 2001 |
| Solid‐Phase, Parallel Syntheses by Ugi Multicomponent Condensation PA Tempest, SD Brown, RW Armstrong Angewandte Chemie International Edition in English 35 (6), 640-642, 1996 | 104 | 1996 |
| Highly efficient microwave-assisted fluorous Ugi and post-condensation reactions for benzimidazoles and quinoxalinones W Zhang, P Tempest Tetrahedron letters 45 (36), 6757-6760, 2004 | 91 | 2004 |
| Aryl nitrogen-containing bicyclic compounds and methods of use V Patel, J Kim, S Geuns-Meyer, S Chaffee, V Cee, B Hodous, S Bellon, ... US Patent App. 11/240,590, 2007 | 80 | 2007 |
| MCC/SNAr methodology. Part 2: Novel three-step solution phase access to libraries of benzodiazepines P Tempest, L Pettus, V Gore, C Hulme Tetrahedron letters 44 (9), 1947-1950, 2003 | 70 | 2003 |
| Design of novel histone deacetylase inhibitors P Siliphaivanh, P Harrington, DJ Witter, K Otte, P Tempest, S Kattar, ... Bioorganic & medicinal chemistry letters 17 (16), 4619-4624, 2007 | 63 | 2007 |
| Melanin concentrating hormone receptor antagonist C Hulme, PA Tempest, V Van Ma, T Nixey, G Balow US Patent 7,514,438, 2009 | 59 | 2009 |
| Protein kinase modulators and method of use SD Geuns-Meyer, BL Hodous, SC Chaffee, PA Tempest, PR Olivieri, ... US Patent 7,880,000, 2011 | 53 | 2011 |
| Library generation via postcondensation modifications of isocyanide-based multicomponent reactions C Hulme, H Bienaymé, T Nixey, B Chenera, W Jones, P Tempest, ... Methods in Enzymology 369, 469-496, 2003 | 52 | 2003 |
| Spirocyclic compounds SC Berk, J Close, C Hamblett, RW Heidebrecht, SD Kattar, LT Kliman, ... US Patent 7,544,695, 2009 | 46 | 2009 |
| Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI-1: 2) optimization SD Kattar, LM Surdi, A Zabierek, JL Methot, RE Middleton, B Hughes, ... Bioorganic & Medicinal Chemistry Letters 19 (4), 1168-1172, 2009 | 40 | 2009 |
