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Tomi Sawyer
Tomi Sawyer
Chief Drug Hunter, Maestro Therapeutics
Verified email at umass.edu - Homepage
Title
Cited by
Cited by
Year
AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance
T O'Hare, WC Shakespeare, X Zhu, CA Eide, VM Rivera, F Wang, ...
Cancer cell 16 (5), 401-412, 2009
14022009
Stapled α− helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy
YS Chang, B Graves, V Guerlavais, C Tovar, K Packman, KH To, ...
Proceedings of the National Academy of Sciences 110 (36), E3445-E3454, 2013
7222013
4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity.
TK Sawyer, PJ Sanfilippo, VJ Hruby, MH Engel, CB Heward, JB Burnett, ...
Proceedings of the National Academy of Sciences 77 (10), 5754-5758, 1980
6651980
A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation
TJ McQuade, AG Tomasselli, L Liu, V Karacostas, B Moss, TK Sawyer, ...
Science 247 (4941), 454-456, 1990
5101990
Probing the α‐helical structural stability of stapled p53 peptides: molecular dynamics simulations and analysis
Z Guo, U Mohanty, J Noehre, TK Sawyer, W Sherman, G Krilov
Chemical biology & drug design 75 (4), 348-359, 2010
4292010
Discovery of 3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a Potent …
WS Huang, CA Metcalf, R Sundaramoorthi, Y Wang, D Zou, RM Thomas, ...
Journal of medicinal chemistry 53 (12), 4701-4719, 2010
3922010
Substrate specificity of the protein tyrosine phosphatases.
ZY Zhang, AM Thieme-Sefler, D Maclean, DJ McNamara, EM Dobrusin, ...
Proceedings of the National Academy of Sciences 90 (10), 4446-4450, 1993
3151993
. alpha.-Melanotropin: the minimal active sequence in the frog skin bioassay
VJ Hruby, BC Wilkes, ME Hadley, F Al-Obeidi, TK Sawyer, DJ Staples, ...
Journal of medicinal chemistry 30 (11), 2126-2130, 1987
3051987
Structure at 2.5-. ANG. resolution of chemically synthesized Human Immunodeficiency Virus Type 1 protease complexed with a hydroxyethylene-based inhibitor
M Jaskolski, AG Tomasselli, TK Sawyer, DG Staples, RL Heinrikson, ...
Biochemistry 30 (6), 1600-1609, 1991
2841991
Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML
T O'Hare, R Pollock, EP Stoffregen, JA Keats, OM Abdullah, EM Moseson, ...
Blood 104 (8), 2532-2539, 2004
2662004
Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell …
VG Brunton, E Avizienyte, VJ Fincham, B Serrels, CA Metcalf III, ...
Cancer research 65 (4), 1335-1342, 2005
2632005
α-melanocyte stimulating hormone: a cyclic α-melanotropin exhibiting superagonist biological activity
TK Sawyer, VJ Hruby, PS Darman, ME Hadley
Proc. Natl. Acad. Sci. USA 79, 1751-1755, 1982
248*1982
Protein tyrosine phosphatase substrate specificity: size and phosphotyrosine positioning requirements in peptide substrates
ZY Zhang, D Maclean, DJ McNamara, TK Sawyer, JE Dixon
Biochemistry 33 (8), 2285-2290, 1994
2381994
Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function
NO Carragher, SM Walker, LA Scott Carragher, F Harris, TK Sawyer, ...
Oncogene 25 (42), 5726-5740, 2006
2132006
The generation of molecular diversity
MR Pavia, TK Sawyer, WH Moos
Bioorganic & Medicinal Chemistry Letters 3 (3), 387-396, 1993
2001993
Src homology‐2 domains: Structure, mechanisms, and drug discovery
TK Sawyer
Peptide Science 47 (3), 243-261, 1998
1861998
Melanotropins: structural, conformational and biological considerations in the development of superpotent and superprolonged analogs
VJ Hruby, BC Wilkes, WL Cody, TK Sawyer, ME Hadley
Pept. Protein Rev 3 (1), 64, 1984
1701984
Structure-based design of an osteoclast-selective, nonpeptide Src homology 2 inhibitor with in vivo antiresorptive activity
W Shakespeare, M Yang, R Bohacek, F Cerasoli, K Stebbins, ...
Proceedings of the National Academy of Sciences 97 (17), 9373-9378, 2000
1672000
Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases
DP Lesslie, JM Summy, NU Parikh, F Fan, JG Trevino, TK Sawyer, ...
British journal of cancer 94 (11), 1710-1717, 2006
1652006
A study of Src SH2 domain protein-phosphopeptide binding interactions by electrospray ionization mass spectrometry
JA Loo, P Hu, P McConnell, WT Mueller, TK Sawyer, V Thanabal
Journal of the American Society for Mass Spectrometry 8 (3), 234-243, 1997
1641997
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