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Michael Garton
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C2H2 zinc finger proteins greatly expand the human regulatory lexicon
HS Najafabadi, S Mnaimneh, FW Schmitges, M Garton, KN Lam, A Yang, ...
Nature biotechnology 33 (5), 555-562, 2015
3362015
Method to generate highly stable D-amino acid analogs of bioactive helical peptides using a mirror image of the entire PDB
M Garton, S Nim, TA Stone, KE Wang, CM Deber, PM Kim
Proceedings of the National Academy of Sciences 115 (7), 1505-1510, 2018
1052018
A structural approach reveals how neighbouring C2H2 zinc fingers influence DNA binding specificity
M Garton, HS Najafabadi, FW Schmitges, E Radovani, TR Hughes, ...
Nucleic acids research 43 (19), 9147-9157, 2015
612015
Strategies to develop inhibitors of motif-mediated protein-protein interactions as drug leads
C Corbi-Verge, M Garton, S Nim, PM Kim
Annual Review of Pharmacology and Toxicology 57, 39-60, 2017
412017
Shifting landscapes of human MTHFR missense-variant effects
J Weile, N Kishore, S Sun, R Maaieh, M Verby, R Li, I Fotiadou, ...
The American Journal of Human Genetics 108 (7), 1283-1300, 2021
382021
Non-base-contacting residues enable kaleidoscopic evolution of metazoan C2H2 zinc finger DNA binding
HS Najafabadi, M Garton, MT Weirauch, S Mnaimneh, A Yang, PM Kim, ...
Genome biology 18, 1-15, 2017
362017
A comprehensive model for the recognition of human telomeres by TRF1
M Garton, C Laughton
Journal of molecular biology 425 (16), 2910-2921, 2013
182013
Interplay of self-association and conformational flexibility in regulating protein function
M Garton, SS MacKinnon, A Malevanets, SJ Wodak
Philosophical Transactions of the Royal Society B: Biological Sciences 373 …, 2018
142018
Rapid and accurate structure‐based therapeutic peptide design using GPU accelerated thermodynamic integration
M Garton, C Corbi‐Verge, Y Hu, S Nim, N Tarasova, B Sherborne, ...
Proteins: Structure, Function, and Bioinformatics 87 (3), 236-244, 2019
102019
The geometric influence on the Cys2His2 zinc finger domain and functional plasticity
AL Mueller, C Corbi-Verge, DO Giganti, DM Ichikawa, JM Spencer, ...
Nucleic Acids Research 48 (11), 6382-6402, 2020
92020
A computational approach for designing D-proteins with non-canonical amino acid optimised binding affinity
M Garton, M Sayadi, PM Kim
Plos one 12 (11), e0187524, 2017
92017
Systematically testing human HMBS missense variants to reveal mechanism and pathogenic variation
W van Loggerenberg, S Sowlati-Hashjin, J Weile, R Hamilton, A Chawla, ...
The American Journal of Human Genetics 110 (10), 1769-1786, 2023
62023
Dawn of a new era for membrane protein design
S Sowlati-Hashjin, A Gandhi, M Garton
BioDesign Research, 2022
62022
ProteinVAE: variational autoencoder for translational protein design
S Lyu, S Sowlati-Hashjin, M Garton
bioRxiv, 2023.03. 04.531110, 2023
32023
A Flexible Transgene Integration ‘Landing-Pad’Toolkit in Human Induced Pluripotent Stem Cells Enables Facile Cellular Engineering, Gene Zygosity Control, and Parallel Transgene …
AH Rosenstein, M Nguyen, R Al-Attar, D Serra, N Gulati, T Yin, PM Gilbert, ...
bioRxiv, 2023.03. 03.531057, 2023
12023
Variational autoencoder for design of synthetic viral vector serotypes
S Lyu, S Sowlati-Hashjin, M Garton
Nature Machine Intelligence, 1-14, 2024
2024
In-silico method for designing a (d)-polypeptide ligand
M Garton, NIM Satra
US Patent App. 16/960,792, 2021
2021
174 Self-association prompts proteins for new function: The role of altered dynamic properties
SJ Wodak, M Garton, A Malevanets, S McKinnon
Journal of Biomolecular Structure and Dynamics 31 (sup1), 112-112, 2013
2013
De Novo Crystallization Condition Prediction with Deep Learning
H Lee, ZH Wu, C Corbi-Verge, M Mok, S Kang, S Liao, Z Zhang, M Garton
Supplementary material a) Protocols (AMBER input files)
M Garton, C Laughton
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Articles 1–20