| The Karyopherin proteins, Crm1 and Karyopherin β1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation PJ Van der Watt, CP Maske, DT Hendricks, MI Parker, L Denny, ... International journal of cancer 124 (8), 1829-1840, 2009 | 360 | 2009 |
| Cross-talk between JNK/SAPK and ERK/MAPK pathways: sustained activation of JNK blocks ERK activation by mitogenic factors YH Shen, J Godlewski, J Zhu, P Sathyanarayana, V Leaner, MJ Birrer, ... Journal of Biological Chemistry 278 (29), 26715-26721, 2003 | 242 | 2003 |
| Targeting the nuclear import receptor Kpnβ1 as an anticancer therapeutic PJ van der Watt, A Chi, T Stelma, C Stowell, E Strydom, S Carden, ... Molecular Cancer Therapeutics 15 (4), 560-573, 2016 | 78 | 2016 |
| NORE1A tumor suppressor candidate modulates p21CIP1 via p53 DF Calvisi, H Donninger, MD Vos, MJ Birrer, L Gordon, V Leaner, ... Cancer research 69 (11), 4629-4637, 2009 | 71 | 2009 |
| AP-1 complexes containing cJun and JunB cause cellular transformation of Rat1a fibroblasts and share transcriptional targets VD Leaner, I Kinoshita, MJ Birrer Oncogene 22 (36), 5619-5629, 2003 | 64 | 2003 |
| Overexpression of Kpnβ1 and Kpnα2 importin proteins in cancer derives from deregulated E2F activity PJ van der Watt, E Ngarande, VD Leaner PLoS One 6 (11), e27723, 2011 | 63 | 2011 |
| The nuclear exporter, Crm1, is regulated by NFY and Sp1 in cancer cells and repressed by p53 in response to DNA damage PJ van der Watt, VD Leaner Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1809 (7), 316-326, 2011 | 61 | 2011 |
| PMA-induced up-regulation of TBX3 is mediated by AP-1 and contributes to breast cancer cell migration S Mowla, R Pinnock, VD Leaner, CR Goding, S Prince Biochemical Journal 433 (1), 145-153, 2011 | 59 | 2011 |
| Targeting nuclear transporters in cancer: diagnostic, prognostic and therapeutic potential T Stelma, A Chi, PJ Van Der Watt, A Verrico, P Lavia, VD Leaner IUBMB life 68 (4), 268-280, 2016 | 58 | 2016 |
| Photolon™, a chlorin e6 derivative, triggers ROS production and light-dependent cell death via necrosis L Copley, P van der Watt, KW Wirtz, MI Parker, VD Leaner The International Journal of Biochemistry & Cell Biology 40 (2), 227-235, 2008 | 58 | 2008 |
| Cyclin A is a c-Jun target gene and is necessary for c-Jun-induced anchorage-independent growth in RAT1a cells M Katabami, H Donninger, F Hommura, VD Leaner, I Kinoshita, JFB Chick, ... Journal of Biological Chemistry 280 (17), 16728-16738, 2005 | 58 | 2005 |
| Inhibition of AP-1 transcriptional activity blocks the migration, invasion, and experimental metastasis of murine osteosarcoma VD Leaner, JF Chick, H Donninger, I Linniola, A Mendoza, C Khanna, ... The American journal of pathology 174 (1), 265-275, 2009 | 57 | 2009 |
| Reactive oxygen species mediated apoptosis of esophageal cancer cells induced by marine triprenyl toluquinones and toluhydroquinones CE Whibley, KL McPhail, RA Keyzers, MF Maritz, VD Leaner, MJ Birrer, ... Molecular cancer therapeutics 6 (9), 2535-2543, 2007 | 50 | 2007 |
| Identification of cJun-responsive genes in Rat-1a cells using multiple techniques: increased expression of stathmin is necessary for cJun-mediated anchorage-independent growth I Kinoshita, V Leaner, M Katabami, RG Manzano, P Dent, A Sabichi, ... Oncogene 22 (18), 2710-2722, 2003 | 48 | 2003 |
| Elevated expression of the nuclear export protein, Crm1 (exportin 1), associates with human oesophageal squamous cell carcinoma PJ Van der Watt, W Zemanay, D Govender, DT Hendricks, MI Parker, ... Oncology Reports 32 (2), 730-738, 2014 | 47 | 2014 |
| Inhibition of the nuclear transporter, Kpnβ1, results in prolonged mitotic arrest and activation of the intrinsic apoptotic pathway in cervical cancer cells L Angus, PJ van der Watt, VD Leaner Carcinogenesis 35 (5), 1121-1131, 2014 | 42 | 2014 |
| HMG-I/Y Is a c-Jun/Activator Protein-1 Target Gene and Is Necessary for c-Jun–Induced Anchorage-Independent Growth in Rat1a Cells F Hommura, M Katabami, VD Leaner, H Donninger, TF Sumter, ... Molecular cancer research 2 (5), 305-314, 2004 | 42 | 2004 |
| The nuclear import receptor Kpnβ1 and its potential as an anticancer therapeutic target PJ van der Watt, CL Stowell, VD Leaner Critical Reviews™ in Eukaryotic Gene Expression 23 (1), 2013 | 37 | 2013 |
| The tumour suppressing role of the circadian clock K Davis, LC Roden, VD Leaner, PJ van der Watt IUBMB life 71 (7), 771-780, 2019 | 36 | 2019 |
| Thymosin β4 Is a Determinant of the Transformed Phenotype and Invasiveness of S-Adenosylmethionine Decarboxylase–Transfected Fibroblasts P Nummela, M Yin, M Kielosto, V Leaner, MJ Birrer, E Hölttä Cancer research 66 (2), 701-712, 2006 | 33 | 2006 |
