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James  Kirkland
James Kirkland
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Year
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
DJ Baker, T Wijshake, T Tchkonia, NK LeBrasseur, BG Childs, ...
Nature 479 (7372), 232-236, 2011
36572011
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
YI Zhu, T Tchkonia, T Pirtskhalava, AC Gower, H Ding, N Giorgadze, ...
Aging cell 14 (4), 644-658, 2015
20252015
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
T Tchkonia, Y Zhu, J Van Deursen, J Campisi, JL Kirkland
The Journal of clinical investigation 123 (3), 966-972, 2013
17312013
Senolytics improve physical function and increase lifespan in old age
M Xu, T Pirtskhalava, JN Farr, BM Weigand, AK Palmer, MM Weivoda, ...
Nature medicine 24 (8), 1246-1256, 2018
16952018
Cellular senescence mediates fibrotic pulmonary disease
MJ Schafer, TA White, K Iijima, AJ Haak, G Ligresti, EJ Atkinson, AL Oberg, ...
Nature communications 8 (1), 14532, 2017
12472017
Fat tissue, aging, and cellular senescence
T Tchkonia, DE Morbeck, T Von Zglinicki, J Van Deursen, J Lustgarten, ...
Aging cell 9 (5), 667-684, 2010
12452010
Sarcopenia: aging-related loss of muscle mass and function
L Larsson, H Degens, M Li, L Salviati, YI Lee, W Thompson, JL Kirkland, ...
Physiological reviews 99 (1), 427-511, 2019
11392019
Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors
YI Zhu, T Tchkonia, H Fuhrmann‐Stroissnigg, HM Dai, YY Ling, MB Stout, ...
Aging cell 15 (3), 428-435, 2016
9422016
Targeting cellular senescence prevents age-related bone loss in mice
JN Farr, M Xu, MM Weivoda, DG Monroe, DG Fraser, JL Onken, ...
Nature medicine 23 (9), 1072-1079, 2017
9272017
Senescence and apoptosis: dueling or complementary cell fates?
BG Childs, DJ Baker, JL Kirkland, J Campisi, JM Van Deursen
EMBO reports 15 (11), 1139-1153, 2014
9012014
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
LTJ Hickson, LGPL Prata, SA Bobart, TK Evans, N Giorgadze, SK Hashmi, ...
EBioMedicine 47, 446-456, 2019
873*2019
Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study
JN Justice, AM Nambiar, T Tchkonia, NK LeBrasseur, R Pascual, ...
EBioMedicine 40, 554-563, 2019
8732019
Cellular senescence: a translational perspective
JL Kirkland, T Tchkonia
EBioMedicine 21, 21-28, 2017
8612017
Cellular senescence drives age-dependent hepatic steatosis
M Ogrodnik, S Miwa, T Tchkonia, D Tiniakos, CL Wilson, A Lahat, CP Day, ...
Nature communications 8 (1), 15691, 2017
7902017
Mechanisms and metabolic implications of regional differences among fat depots
T Tchkonia, T Thomou, YI Zhu, I Karagiannides, C Pothoulakis, ...
Cell metabolism 17 (5), 644-656, 2013
7592013
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
CM Roos, B Zhang, AK Palmer, MB Ogrodnik, T Pirtskhalava, NM Thalji, ...
Aging cell 15 (5), 973-977, 2016
6872016
Senolytic drugs: from discovery to translation
JL Kirkland, T Tchkonia
Journal of internal medicine 288 (5), 518-536, 2020
6852020
Fisetin is a senotherapeutic that extends health and lifespan
MJ Yousefzadeh, YI Zhu, SJ McGowan, L Angelini, ...
EBioMedicine 36, 18-28, 2018
6822018
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
M Xu, T Tchkonia, H Ding, M Ogrodnik, ER Lubbers, T Pirtskhalava, ...
Proceedings of the National Academy of Sciences 112 (46), E6301-E6310, 2015
6792015
Identification of HSP90 inhibitors as a novel class of senolytics
H Fuhrmann-Stroissnigg, YY Ling, J Zhao, SJ McGowan, YI Zhu, ...
Nature communications 8 (1), 422, 2017
5892017
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