Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders DJ Baker, T Wijshake, T Tchkonia, NK LeBrasseur, BG Childs, ... Nature 479 (7372), 232-236, 2011 | 3657 | 2011 |
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs YI Zhu, T Tchkonia, T Pirtskhalava, AC Gower, H Ding, N Giorgadze, ... Aging cell 14 (4), 644-658, 2015 | 2025 | 2015 |
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities T Tchkonia, Y Zhu, J Van Deursen, J Campisi, JL Kirkland The Journal of clinical investigation 123 (3), 966-972, 2013 | 1731 | 2013 |
Senolytics improve physical function and increase lifespan in old age M Xu, T Pirtskhalava, JN Farr, BM Weigand, AK Palmer, MM Weivoda, ... Nature medicine 24 (8), 1246-1256, 2018 | 1695 | 2018 |
Cellular senescence mediates fibrotic pulmonary disease MJ Schafer, TA White, K Iijima, AJ Haak, G Ligresti, EJ Atkinson, AL Oberg, ... Nature communications 8 (1), 14532, 2017 | 1247 | 2017 |
Fat tissue, aging, and cellular senescence T Tchkonia, DE Morbeck, T Von Zglinicki, J Van Deursen, J Lustgarten, ... Aging cell 9 (5), 667-684, 2010 | 1245 | 2010 |
Sarcopenia: aging-related loss of muscle mass and function L Larsson, H Degens, M Li, L Salviati, YI Lee, W Thompson, JL Kirkland, ... Physiological reviews 99 (1), 427-511, 2019 | 1139 | 2019 |
Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors YI Zhu, T Tchkonia, H Fuhrmann‐Stroissnigg, HM Dai, YY Ling, MB Stout, ... Aging cell 15 (3), 428-435, 2016 | 942 | 2016 |
Targeting cellular senescence prevents age-related bone loss in mice JN Farr, M Xu, MM Weivoda, DG Monroe, DG Fraser, JL Onken, ... Nature medicine 23 (9), 1072-1079, 2017 | 927 | 2017 |
Senescence and apoptosis: dueling or complementary cell fates? BG Childs, DJ Baker, JL Kirkland, J Campisi, JM Van Deursen EMBO reports 15 (11), 1139-1153, 2014 | 901 | 2014 |
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease LTJ Hickson, LGPL Prata, SA Bobart, TK Evans, N Giorgadze, SK Hashmi, ... EBioMedicine 47, 446-456, 2019 | 873* | 2019 |
Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study JN Justice, AM Nambiar, T Tchkonia, NK LeBrasseur, R Pascual, ... EBioMedicine 40, 554-563, 2019 | 873 | 2019 |
Cellular senescence: a translational perspective JL Kirkland, T Tchkonia EBioMedicine 21, 21-28, 2017 | 861 | 2017 |
Cellular senescence drives age-dependent hepatic steatosis M Ogrodnik, S Miwa, T Tchkonia, D Tiniakos, CL Wilson, A Lahat, CP Day, ... Nature communications 8 (1), 15691, 2017 | 790 | 2017 |
Mechanisms and metabolic implications of regional differences among fat depots T Tchkonia, T Thomou, YI Zhu, I Karagiannides, C Pothoulakis, ... Cell metabolism 17 (5), 644-656, 2013 | 759 | 2013 |
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice CM Roos, B Zhang, AK Palmer, MB Ogrodnik, T Pirtskhalava, NM Thalji, ... Aging cell 15 (5), 973-977, 2016 | 687 | 2016 |
Senolytic drugs: from discovery to translation JL Kirkland, T Tchkonia Journal of internal medicine 288 (5), 518-536, 2020 | 685 | 2020 |
Fisetin is a senotherapeutic that extends health and lifespan MJ Yousefzadeh, YI Zhu, SJ McGowan, L Angelini, ... EBioMedicine 36, 18-28, 2018 | 682 | 2018 |
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age M Xu, T Tchkonia, H Ding, M Ogrodnik, ER Lubbers, T Pirtskhalava, ... Proceedings of the National Academy of Sciences 112 (46), E6301-E6310, 2015 | 679 | 2015 |
Identification of HSP90 inhibitors as a novel class of senolytics H Fuhrmann-Stroissnigg, YY Ling, J Zhao, SJ McGowan, YI Zhu, ... Nature communications 8 (1), 422, 2017 | 589 | 2017 |