| Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1 YM Li, M Xu, MT Lai, Q Huang, JL Castro, J DiMuzio-Mower, T Harrison, ... Nature 405 (6787), 689-694, 2000 | 1202 | 2000 |
| c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma AP Weng, JM Millholland, Y Yashiro-Ohtani, ML Arcangeli, A Lau, C Wai, ... Genes & development 20 (15), 2096-2109, 2006 | 1077 | 2006 |
| Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors X Fan, W Matsui, L Khaki, D Stearns, J Chun, YM Li, CG Eberhart Cancer research 66 (15), 7445-7452, 2006 | 813 | 2006 |
| NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts X Fan, L Khaki, TS Zhu, ME Soules, CE Talsma, N Gul, C Koh, J Zhang, ... Stem cells 28 (1), 5-16, 2010 | 788 | 2010 |
| Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state YM Li, MT Lai, M Xu, Q Huang, J DiMuzio-Mower, MK Sardana, XP Shi, ... Proceedings of the National Academy of Sciences 97 (11), 6138-6143, 2000 | 720 | 2000 |
| Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization H Xu, J Zhu, S Smith, J Foldi, B Zhao, AY Chung, H Outtz, J Kitajewski, ... Nature immunology 13 (7), 642-650, 2012 | 440 | 2012 |
| The role of astrocytes in amyloid production and Alzheimer's disease GR Frost, YM Li Open biology 7 (12), 170228, 2017 | 383 | 2017 |
| Cantharidin-binding protein: identification as protein phosphatase 2A. YM Li, JE Casida Proceedings of the National Academy of Sciences 89 (24), 11867-11870, 1992 | 379 | 1992 |
| γ-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity RD Meng, CC Shelton, YM Li, LX Qin, D Notterman, PB Paty, ... Cancer research 69 (2), 573-582, 2009 | 343 | 2009 |
| From peptide precursors to oxazole and thiazole-containing peptide antibiotics: microcin B17 synthase YM Li, JC Milne, LL Madison, R Kolter, CT Walsh Science 274 (5290), 1188-1193, 1996 | 341 | 1996 |
| Modulation of γ-secretase reduces β-amyloid deposition in a transgenic mouse model of Alzheimer's disease MZ Kounnas, AM Danks, S Cheng, C Tyree, E Ackerman, X Zhang, K Ahn, ... Neuron 67 (5), 769-780, 2010 | 294 | 2010 |
| A presenilin dimer at the core of the γ-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis EH Schroeter, MXG Ilagan, AL Brunkan, S Hecimovic, Y Li, M Xu, ... Proceedings of the National Academy of Sciences 100 (22), 13075-13080, 2003 | 262 | 2003 |
| Gleevec inhibits β-amyloid production but not Notch cleavage WJ Netzer, F Dou, D Cai, D Veach, S Jean, Y Li, WG Bornmann, ... Proceedings of the National Academy of Sciences 100 (21), 12444-12449, 2003 | 254 | 2003 |
| Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer ME Mullendore, JB Koorstra, YM Li, GJ Offerhaus, X Fan, CM Henderson, ... Clinical Cancer Research 15 (7), 2291-2301, 2009 | 238 | 2009 |
| Arc/Arg3. 1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation J Wu, RS Petralia, H Kurushima, H Patel, M Jung, L Volk, S Chowdhury, ... Cell 147 (3), 615-628, 2011 | 223 | 2011 |
| Presenilin-1 and presenilin-2 exhibit distinct yet overlapping γ-secretase activities MT Lai, E Chen, MC Crouthamel, J DiMuzio-Mower, M Xu, Q Huang, ... Journal of Biological Chemistry 278 (25), 22475-22481, 2003 | 213 | 2003 |
| Development and mechanism of γ-secretase modulators for Alzheimer’s disease CJ Crump, DS Johnson, YM Li Biochemistry 52 (19), 3197-3216, 2013 | 203 | 2013 |
| Protein phosphatase 2A and its [3H] cantharidin/[3H] endothall thioanhydride binding site: inhibitor specificity of cantharidin and ATP analogues YM Li, C Mackintosh, JE Casida Biochemical pharmacology 46 (8), 1435-1443, 1993 | 194 | 1993 |
| Activation and intrinsic γ-secretase activity of presenilin 1 K Ahn, CC Shelton, Y Tian, X Zhang, ML Gilchrist, SS Sisodia, YM Li Proceedings of the National Academy of Sciences 107 (50), 21435-21440, 2010 | 190 | 2010 |
| The pro domain of β-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain XP Shi, E Chen, KC Yin, S Na, VM Garsky, MT Lai, YM Li, M Platchek, ... Journal of Biological Chemistry 276 (13), 10366-10373, 2001 | 180 | 2001 |
