| Transneuronal propagation of pathologic α-synuclein from the gut to the brain models Parkinson’s disease S Kim, SH Kwon, TI Kam, N Panicker, SS Karuppagounder, S Lee, JH Lee, ... Neuron 103 (4), 627-641. e7, 2019 | 1037 | 2019 |
| Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease SP Yun, TI Kam, N Panicker, SM Kim, Y Oh, JS Park, SH Kwon, YJ Park, ... Nature medicine 24 (7), 931-938, 2018 | 848 | 2018 |
| Overexpression of Atg5 in mice activates autophagy and extends lifespan JO Pyo, SM Yoo, HH Ahn, J Nah, SH Hong, TI Kam, S Jung, YK Jung Nature communications 4 (1), 2300, 2013 | 720 | 2013 |
| Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3 X Mao, MT Ou, SS Karuppagounder, TI Kam, X Yin, Y Xiong, P Ge, ... Science 353 (6307), aah3374, 2016 | 675 | 2016 |
| Poly (ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease TI Kam, X Mao, H Park, SC Chou, SS Karuppagounder, GE Umanah, ... Science 362 (6414), eaat8407, 2018 | 393 | 2018 |
| A nuclease that mediates cell death induced by DNA damage and poly (ADP-ribose) polymerase-1 Y Wang, R An, GK Umanah, H Park, K Nambiar, SM Eacker, BW Kim, ... Science 354 (6308), aad6872, 2016 | 323 | 2016 |
| Microglia and astrocyte dysfunction in parkinson's disease TI Kam, JT Hinkle, TM Dawson, VL Dawson Neurobiology of disease 144, 105028, 2020 | 224 | 2020 |
| Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia N Panicker, S Sarkar, DS Harischandra, M Neal, TI Kam, H Jin, ... Journal of Experimental Medicine 216 (6), 1411-1430, 2019 | 198 | 2019 |
| PINK1 primes Parkin-mediated ubiquitination of PARIS in dopaminergic neuronal survival Y Lee, DA Stevens, SU Kang, H Jiang, YI Lee, HS Ko, LA Scarffe, ... Cell reports 18 (4), 918-932, 2017 | 180 | 2017 |
| FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer’s disease TI Kam, S Song, Y Gwon, H Park, JJ Yan, I Im, JW Choi, TY Choi, J Kim, ... The Journal of clinical investigation 123 (7), 2791-2802, 2013 | 146 | 2013 |
| Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer’s disease JS Park, TI Kam, S Lee, H Park, Y Oh, SH Kwon, JJ Song, D Kim, H Kim, ... Acta neuropathologica communications 9 (1), 78, 2021 | 104 | 2021 |
| E2-25K/Hip-2 regulates caspase-12 in ER stress–mediated Aβ neurotoxicity S Song, H Lee, TI Kam, ML Tai, JY Lee, JY Noh, SM Shim, SJ Seo, ... The Journal of Cell Biology 182 (4), 675-684, 2008 | 96 | 2008 |
| Neuropathogenic role of adenylate kinase-1 in Aβ-mediated tau phosphorylation via AMPK and GSK3β H Park, TI Kam, Y Kim, H Choi, Y Gwon, C Kim, JY Koh, YK Jung Human molecular genetics 21 (12), 2725-2737, 2012 | 90 | 2012 |
| α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism SP Yun, D Kim, S Kim, SM Kim, SS Karuppagounder, SH Kwon, S Lee, ... Molecular neurodegeneration 13, 1-19, 2018 | 84 | 2018 |
| Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease N Panicker, TI Kam, H Wang, S Neifert, SC Chou, M Kumar, ... Neuron 110 (15), 2422-2437. e9, 2022 | 82 | 2022 |
| Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity JC Xu, J Fan, X Wang, SM Eacker, TI Kam, L Chen, X Yin, J Zhu, Z Chi, ... Science translational medicine 8 (333), 333ra48-333ra48, 2016 | 78 | 2016 |
| Poly (ADP-ribose)(PAR)-dependent cell death in neurodegenerative diseases H Park, TI Kam, TM Dawson, VL Dawson International review of cell and molecular biology 353, 1-29, 2020 | 75 | 2020 |
| Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model YD Kim, H Choi, WJ Lee, H Park, TI Kam, S Hong, J Nah, S Jung, B Shin, ... Neurobiology of disease 87, 19-28, 2016 | 67 | 2016 |
| Amyloid beta receptors responsible for neurotoxicity and cellular defects in Alzheimer’s disease TI Kam, Y Gwon, YK Jung Cellular and molecular life sciences 71, 4803-4813, 2014 | 64 | 2014 |
| FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model TI Kam, H Park, Y Gwon, S Song, SH Kim, SW Moon, DG Jo, YK Jung Elife 5, e18691, 2016 | 58 | 2016 |
Ted M. DawsonDirector, Institute for Cell Engineering, Professor of Neurology and Neuroscience, JHUSoMVerified email at jhmi.edu
