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| Engineered ribosyl-1-kinase enables concise synthesis of molnupiravir, an antiviral for COVID-19 JA McIntosh, T Benkovics, SM Silverman, MA Huffman, J Kong, ... ACS Central Science 7 (12), 1980-1985, 2021 | 100 | 2021 |
| Increasing sequence diversity with flexible backbone protein design: the complete redesign of a protein hydrophobic core GS Murphy, JL Mills, MJ Miley, M Machius, T Szyperski, B Kuhlman Structure 20 (6), 1086-1096, 2012 | 73 | 2012 |
| A de novo enzyme catalyzes a life-sustaining reaction in Escherichia coli AE Donnelly, GS Murphy, KM Digianantonio, MH Hecht Nature Chemical Biology 14 (3), 253-255, 2018 | 61 | 2018 |
| A kinase-cGAS cascade to synthesize a therapeutic STING activator JA McIntosh, Z Liu, BM Andresen, NS Marzijarani, JC Moore, NM Marshall, ... Nature 603 (7901), 439-444, 2022 | 60 | 2022 |
| De Novo Proteins with Life-Sustaining Functions Are Structurally Dynamic GS Murphy, JB Greisman, MH Hecht Journal of molecular biology 428 (2), 399-411, 2016 | 35 | 2016 |
| Structure and function of palladin's actin binding domain MR Beck, RDS Dixon, SM Goicoechea, GS Murphy, JG Brungardt, ... Journal of molecular biology 425 (18), 3325-3337, 2013 | 31 | 2013 |
| Computational de novo design of a four‐helix bundle protein—DND _4 HB GS Murphy, B Sathyamoorthy, BS Der, MC Machius, SV Pulavarti, ... Protein Science 24 (4), 434-445, 2015 | 27 | 2015 |
| Evolving to an ideal synthesis of molnupiravir, an investigational treatment for COVID-19 T Benkovics, J McIntosh, S Silverman, J Kong, P Maligres, T Itoh, H Yang, ... | 21 | 2020 |
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| Role of simple descriptors and applicability domain in predicting change in protein thermostability KN McGuinness, W Pan, RP Sheridan, G Murphy, A Crespo PLoS One 13 (9), e0203819, 2018 | 14 | 2018 |
| KA Canada, PG Bulger, BD Sherry, MD Truppo, RT Ruck, L.-C. Campeau, DJ Bennett, GR Humphrey, KR Campos and ML Maddess, A Kinase-cGAS Cascade to Synthesize a Therapeutic STING … JA McIntosh, Z Liu, BM Andresen, NS Marzijarani, JC Moore, NM Marshall, ... Nature 603, 439-444, 2022 | 9 | 2022 |
| Amination of a Green Solvent via Immobilized Biocatalysis for the Synthesis of Nemtabrutinib CK Prier, K Camacho Soto, JH Forstater, N Kuhl, JT Kuethe, ... Acs Catalysis 13 (12), 7707-7714, 2023 | 7 | 2023 |
| Mutation maker, an open source oligo design platform for protein engineering K Hiraga, P Mejzlik, M Marcisin, N Vostrosablin, A Gromek, J Arnold, ... ACS Synthetic Biology 10 (2), 357-370, 2021 | 7 | 2021 |
| Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan WL Cheung‐Lee, JN Kolev, JA McIntosh, AA Gil, W Pan, L Xiao, ... Angewandte Chemie International Edition, e202316133, 2024 | 6 | 2024 |
| Ketoreductase polypeptides and polynucleotides JC Moore, J Liang, J Penfield, J Nazor, N Dellas, V Mitchell, D Duan, ... US Patent 11,021,729, 2021 | 4 | 2021 |
| Engineered phosphopentomutase variant enzymes SJ Novick, X Yi, N Dellas, O Alvizo, J Nazor, D Duan, V Mitchell, J Vroom, ... US Patent 11,034,948, 2021 | 3 | 2021 |
| Engineered pantothenate kinase variant enzymes MT Borra-Garske, O Alvizo, LJ Miller, JB Slaton, AL Petkova, ... US Patent 10,889,806, 2021 | 3 | 2021 |
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| Directed Evolution to Reverse Epoxide Hydrolase Enantioselectivity for meso‐3,4‐Epoxytetrahydrofuran K Hiraga, T Itoh, D Verma, W Wang, C Huang, M Ardolino, YL Zhong, ... ChemCatChem 15 (12), e202300238, 2023 | 1 | 2023 |
