| Human iPSC-derived blood-brain barrier microvessels: validation of barrier function and endothelial cell behavior RM Linville, JG DeStefano, MB Sklar, Z Xu, AM Farrell, MI Bogorad, ... Biomaterials 190, 24-37, 2019 | 164 | 2019 |
| Benchmarking in vitro tissue-engineered blood–brain barrier models JG DeStefano, JJ Jamieson, RM Linville, PC Searson Fluids and Barriers of the CNS 15, 1-15, 2018 | 127 | 2018 |
| Role of iPSC-derived pericytes on barrier function of iPSC-derived brain microvascular endothelial cells in 2D and 3D JJ Jamieson, RM Linville, YY Ding, S Gerecht, PC Searson Fluids and Barriers of the CNS 16, 1-16, 2019 | 105 | 2019 |
| Functional brain-specific microvessels from iPSC-derived human brain microvascular endothelial cells: the role of matrix composition on monolayer formation ME Katt, RM Linville, LN Mayo, ZS Xu, PC Searson Fluids and Barriers of the CNS 15, 1-12, 2018 | 99 | 2018 |
| Tissue-engineered blood-brain barrier models via directed differentiation of human induced pluripotent stem cells GN Grifno, AM Farrell, RM Linville, D Arevalo, JH Kim, L Gu, PC Searson Scientific reports 9 (1), 13957, 2019 | 87 | 2019 |
| A tissue-engineered 3D microvessel model reveals the dynamics of mosaic vessel formation in breast cancer VL Silvestri, E Henriet, RM Linville, AD Wong, PC Searson, AJ Ewald Cancer research 80 (19), 4288-4301, 2020 | 84 | 2020 |
| Physical and Chemical Signals That Promote Vascularization of Capillary-Scale Channels RM Linville, NF Boland, G Covarrubias, GM Price, J Tien Cellular and Molecular Bioengineering, 2016 | 58 | 2016 |
| Modeling hyperosmotic blood–brain barrier opening within human tissue-engineered in vitro brain microvessels RM Linville, JG DeStefano, MB Sklar, C Chu, P Walczak, PC Searson Journal of Cerebral Blood Flow & Metabolism 40 (7), 1517-1532, 2020 | 48 | 2020 |
| Cerebrovascular plasticity: Processes that lead to changes in the architecture of brain microvessels MI Bogorad, JG DeStefano, RM Linville, AD Wong, PC Searson Journal of Cerebral Blood Flow & Metabolism 39 (8), 1413-1432, 2019 | 48 | 2019 |
| Optimization of osmotic blood-brain barrier opening to enable intravital microscopy studies on drug delivery in mouse cortex C Chu, A Jablonska, WG Lesniak, AM Thomas, X Lan, RM Linville, S Li, ... Journal of controlled release 317, 312-321, 2020 | 39 | 2020 |
| IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function L Casciola-Rosen, DR Thiemann, F Andrade, MI Trejo-Zambrano, ... JCI insight 7 (9), 2022 | 29 | 2022 |
| Reversible blood-brain barrier opening utilizing the membrane active peptide melittin in vitro and in vivo RM Linville, A Komin, X Lan, JG DeStefano, C Chu, G Liu, P Walczak, ... Biomaterials 275, 120942, 2021 | 24 | 2021 |
| Next-generation in vitro blood–brain barrier models: benchmarking and improving model accuracy RM Linville, PC Searson Fluids and Barriers of the CNS 18, 1-7, 2021 | 22 | 2021 |
| Three-dimensional induced pluripotent stem-cell models of human brain angiogenesis RM Linville, D Arevalo, JC Maressa, N Zhao, PC Searson Research Square, 2019 | 22 | 2019 |
| Three-dimensional induced pluripotent stem-cell models of human brain angiogenesis RM Linville, D Arevalo, JC Maressa, N Zhao, PC Searson Microvascular Research 132, 2020 | 21 | 2020 |
| Long-term cryopreservation preserves blood–brain barrier phenotype of iPSC-derived brain microvascular endothelial cells and three-dimensional microvessels RM Linville, JG DeStefano, RF Nerenberg, GN Grifno, R Ye, E Gallagher, ... Molecular pharmaceutics 17 (9), 3425-3434, 2020 | 19 | 2020 |
| Neuroinflammation in primary blast neurotrauma: Time course and prevention by torso shielding L Xu, ML Schaefer, RM Linville, A Aggarwal, W Mbuguiro, BA Wester, ... Experimental neurology 277, 268-274, 2016 | 19 | 2016 |
| Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood–brain barrier microvessels RM Linville, MB Sklar, GN Grifno, RF Nerenberg, J Zhou, R Ye, ... Fluids and Barriers of the CNS 19 (1), 87, 2022 | 15 | 2022 |
| Engineering the human blood–brain barrier at the capillary scale using a double‐templating technique N Zhao, Z Guo, S Kulkarni, D Norman, S Zhang, TD Chung, ... Advanced functional materials 32 (30), 2110289, 2022 | 15 | 2022 |
| Effects of acute and chronic oxidative stress on the blood–brain barrier in 2D and 3D in vitro models TD Chung, RM Linville, Z Guo, R Ye, R Jha, GN Grifno, PC Searson Fluids and Barriers of the CNS 19 (1), 33, 2022 | 10 | 2022 |
Peter SearsonReynolds Professor of Engineering, Johns Hopkins UniversityVerified email at jhu.edu
