| T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells E Zah, MY Lin, A Silva-Benedict, MC Jensen, YY Chen Cancer Immunology Research 4 (6), 498-508, 2016 | 608 | 2016 |
| Engineering CAR-T cells for next-generation cancer therapy M Hong, JD Clubb, YY Chen Cancer Cell, 2020 | 447 | 2020 |
| Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems YY Chen, MC Jensen, CD Smolke Proceedings of the National Academy of Sciences 107 (19), 8531-8536, 2010 | 319 | 2010 |
| Navigating CAR-T cells through the solid-tumour microenvironment AJ Hou, LC Chen, YY Chen Nature Reviews Drug Discovery, 1-20, 2021 | 305 | 2021 |
| Rewiring T-cell responses to soluble factors with chimeric antigen receptors ZNL Chang, MH Lorenzini, X Chen, U Tran, NJ Bangayan, YY Chen Nature chemical biology 14 (3), 317, 2018 | 235 | 2018 |
| CAR-T design: Elements and their synergistic function J Jayaraman, MP Mellody, AJ Hou, RP Desai, AW Fung, AHT Pham, ... EBioMedicine 58, 102931, 2020 | 199 | 2020 |
| Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma E Zah, E Nam, V Bhuvan, U Tran, BY Ji, SB Gosliner, X Wang, CE Brown, ... Nature communications 11 (1), 1-13, 2020 | 173 | 2020 |
| CARs: synthetic immunoreceptors for cancer therapy and beyond ZNL Chang, YY Chen Trends in molecular medicine 23 (5), 430-450, 2017 | 130 | 2017 |
| Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing CL Beisel, YY Chen, SJ Culler, KG Hoff, CD Smolke Nucleic acids research 39 (7), 2981-2994, 2011 | 125 | 2011 |
| Quantitative Analyses of Core Promoters Enable Precise Engineering of Regulated Gene Expression in Mammalian Cells C Ede, X Chen, MY Lin, YY Chen ACS Synthetic Biology, 2016 | 98 | 2016 |
| Synthetic biology: advancing biological frontiers by building synthetic systems YY Chen, KE Galloway, CD Smolke Genome Biol 13 (2), 240, 2012 | 96 | 2012 |
| Continued protein synthesis at low [ATP] and [GTP] enables cell adaptation during energy limitation MC Jewett, ML Miller, YY Chen, JR Swartz Journal of Bacteriology 191, 1083-1091, 2009 | 87 | 2009 |
| Synthetic biology advances and applications in the biotechnology industry: a perspective L Katz, YY Chen, R Gonzalez, TC Peterson, H Zhao, RH Baltz Journal of Industrial Microbiology and Biotechnology 45 (7), 449-461, 2018 | 86 | 2018 |
| TGF‐β–responsive CAR‐T cells promote anti‐tumor immune function AJ Hou, ZNL Chang, MH Lorenzini, E Zah, YY Chen Bioengineering & Translational Medicine, 2018 | 84 | 2018 |
| Unique challenges for glioblastoma immunotherapy—discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. Meeting Report from the 2019 SNO Immuno … P Chuntova, F Chow, PB Watchmaker, M Galvez, AB Heimberger, ... Neuro-oncology 23 (3), 356-375, 2021 | 66 | 2021 |
| The sound of silence: Transgene silencing in mammalian cell engineering A Cabera, HI Edelstein, F Glykofrydis, KS Love, S Palacios, J Tycko, ... Cell Systems 13 (12), 950-973, 2022 | 49 | 2022 |
| From DNA to targeted therapeutics: bringing synthetic biology to the clinic YY Chen, CD Smolke Science translational medicine 3 (106), 106ps42-106ps42, 2011 | 47 | 2011 |
| A yeast‐based rapid prototype platform for gene control elements in mammalian cells KY Wei, YY Chen, CD Smolke Biotechnology and bioengineering 110 (4), 1201-1210, 2013 | 38 | 2013 |
| CD19/CD20 bispecific chimeric antigen receptor (CAR) in naïve/memory T cells for the treatment of relapsed or refractory non-Hodgkin lymphoma. SM Larson, C Walthers, B Ji, SN Ghafouri, J Naparstek, J Trent, C Harris, ... Cancer Discovery 13 (3), 580–597, 2023 | 33 | 2023 |
| Increasing T cell versatility with SUPRA CARs YY Chen Cell 173 (6), 1316-1317, 2018 | 33 | 2018 |
