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Daniel J. Karst
Daniel J. Karst
Manufacturing Scientist, Biogen
Verified email at biogen.com
Title
Cited by
Cited by
Year
Characterization and comparison of ATF and TFF in stirred bioreactors for continuous mammalian cell culture processes
DJ Karst, E Serra, TK Villiger, M Soos, M Morbidelli
Biochemical Engineering Journal 110, 17-26, 2016
1422016
Process performance and product quality in an integrated continuous antibody production process
DJ Karst, F Steinebach, M Soos, M Morbidelli
Biotechnology and bioengineering 114 (2), 298-307, 2017
1372017
Design and operation of a continuous integrated monoclonal antibody production process
F Steinebach, N Ulmer, M Wolf, L Decker, V Schneider, R Wälchli, D Karst, ...
Biotechnology Progress 33 (5), 1303-1313, 2017
1042017
Continuous integrated manufacturing of therapeutic proteins
DJ Karst, F Steinebach, M Morbidelli
Current opinion in biotechnology 53, 76-84, 2018
1032018
Model based adaptive control of a continuous capture process for monoclonal antibodies production
F Steinebach, M Angarita, DJ Karst, T Müller-Späth, M Morbidelli
Journal of Chromatography A 1444, 50-56, 2016
922016
Experimental and CFD physical characterization of animal cell bioreactors: From micro-to production scale
TK Villiger, B Neunstoecklin, DJ Karst, E Lucas, M Stettler, H Broly, ...
Biochemical Engineering Journal 131, 84-94, 2018
832018
Modulation and modeling of monoclonal antibody N‐linked glycosylation in mammalian cell perfusion reactors
DJ Karst, E Scibona, E Serra, JM Bielser, J Souquet, M Stettler, H Broly, ...
Biotechnology and Bioengineering 114 (9), 1978-1990, 2017
742017
Development of a shake tube‐based scale‐down model for perfusion cultures
MKF Wolf, V Lorenz, DJ Karst, J Souquet, H Broly, M Morbidelli
Biotechnology and bioengineering 115 (11), 2703-2713, 2018
432018
Intracellular CHO cell metabolite profiling reveals steady‐state dependent metabolic fingerprints in perfusion culture
DJ Karst, RF Steinhoff, MRG Kopp, E Serra, M Soos, R Zenobi, ...
Biotechnology progress 33 (4), 879-890, 2017
362017
Microarray-based MALDI-TOF mass spectrometry enables monitoring of monoclonal antibody production in batch and perfusion cell cultures
RF Steinhoff, DJ Karst, F Steinebach, MRG Kopp, GW Schmidt, A Stettler, ...
Methods 104, 33-40, 2016
202016
A two-step procedure for the design of perfusion bioreactors
MKF Wolf, A Pechlaner, V Lorenz, DJ Karst, J Souquet, H Broly, ...
Biochemical engineering journal 151, 107295, 2019
172019
Transcriptome and proteome analysis of steady‐state in a perfusion CHO cell culture process
V Bertrand, DJ Karst, A Bachmann, K Cantalupo, M Soos, M Morbidelli
Biotechnology and bioengineering 116 (8), 1959-1972, 2019
172019
Isotope labeling to determine the dynamics of metabolic response in CHO cell perfusion bioreactors using MALDI‐TOF‐MS
DJ Karst, RF Steinhoff, MRG Kopp, M Soos, R Zenobi, M Morbidelli
Biotechnology progress 33 (6), 1630-1639, 2017
102017
Monitoring of antibody glycosylation pattern based on microarray MALDI-TOF mass spectrometry
J Hajduk, M Wolf, R Steinhoff, D Karst, J Souquet, H Broly, M Morbidelli, ...
Journal of biotechnology 302, 77-84, 2019
72019
Characterization and comparison of ATF and TFF in stirred bioreactors for the continuous production of therapeutic proteins
DJ Karst, E Serra, TK Villiger, M Soos, M Morbidelli
Biochemical Engineering Journal 110, 17-26, 2016
72016
Modulation of transmembrane pressure in manufacturing scale tangential flow filtration N‐1 perfusion seed culture
DJ Karst, K Ramer, EH Hughes, C Jiang, PJ Jacobs, FG Mitchelson
Biotechnology Progress 36 (6), e3040, 2020
62020
Integrated continuous processing for the manufacture of monoclonal antibodies
D Karst, F Steinenbach, M Morbidelli
42015
Design of integrated continuous processes for high-quality biotherapeutics
F Steinebach, D Karst, M Morbidelli
Continuous Biomanufacturing-Innovative Technologies and Methods, 457-480, 2017
22017
Tuning metabolic efficiency for increased product yield in high titer fed‐batch Chinese hamster ovary cell culture
A Helfer, S Gros, D Kolwyck, DJ Karst
Biotechnology Progress 39 (3), e3327, 2023
12023
Perfusion cell culture: Challenges and potentials between lab and manufacturing scale
DJ Karst
12018
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Articles 1–20