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Douglas Covey
Douglas Covey
Professor Pharmacology, Washington University
Verified email at wustl.edu - Homepage
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Cited by
Cited by
Year
Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex
BM Castellano, AM Thelen, O Moldavski, MK Feltes, REN Van Der Welle, ...
Science 355 (6331), 1306-1311, 2017
4652017
Pentylenetetrazole-induced inhibition of recombinant γ-aminobutyric acid type A (GABAA) receptors: mechanism and site of action
RQ Huang, CL Bell-Horner, MI Dibas, DF Covey, JA Drewe, GH Dillon
Journal of Pharmacology and Experimental Therapeutics 298 (3), 986-995, 2001
4542001
The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response
M Blanc, WY Hsieh, KA Robertson, KA Kropp, T Forster, G Shui, P Lacaze, ...
Immunity 38 (1), 106-118, 2013
3872013
Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands
C Yang, JG McDonald, A Patel, Y Zhang, M Umetani, F Xu, EJ Westover, ...
Journal of Biological Chemistry 281 (38), 27816-27826, 2006
3682006
Structural basis of Smoothened regulation by its extracellular domains
EFX Byrne, R Sircar, PS Miller, G Hedger, G Luchetti, S Nachtergaele, ...
Nature 535 (7613), 517-522, 2016
3492016
Gastrointestinal absorption and plasma kinetics of soy Δ5-phytosterols and phytostanols in humans
RE Ostlund Jr, JB McGill, CM Zeng, DF Covey, J Stearns, WF Stenson, ...
American Journal of Physiology-Endocrinology and Metabolism 282 (4), E911-E916, 2002
3372002
Oxysterols are allosteric activators of the oncoprotein Smoothened
S Nachtergaele, LK Mydock, K Krishnan, J Rammohan, PH Schlesinger, ...
Nature chemical biology 8 (2), 211-220, 2012
3172012
Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis
T Bordet, B Buisson, M Michaud, C Drouot, P Galéa, P Delaage, ...
Journal of Pharmacology and Experimental Therapeutics 322 (2), 709-720, 2007
3122007
Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids …
Y Li, M Ge, L Ciani, G Kuriakose, EJ Westover, M Dura, DF Covey, ...
Journal of Biological Chemistry 279 (35), 37030-37039, 2004
3082004
Fatty acid synthesis configures the plasma membrane for inflammation in diabetes
X Wei, H Song, L Yin, MG Rizzo, R Sidhu, DF Covey, DS Ory, ...
Nature 539 (7628), 294-298, 2016
2642016
Anticonvulsant medications extend worm life-span
K Evason, C Huang, I Yamben, DF Covey, K Kornfeld
science 307 (5707), 258-262, 2005
2272005
Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling
G Luchetti, R Sircar, JH Kong, S Nachtergaele, A Sagner, EFX Byrne, ...
Elife 5, e20304, 2016
2252016
Neurosteroids, stress and depression: potential therapeutic opportunities
CF Zorumski, SM Paul, Y Izumi, DF Covey, S Mennerick
Neuroscience & Biobehavioral Reviews 37 (1), 109-122, 2013
1962013
Interaction of picrotoxin with GABAA receptor channel-lining residues probed in cysteine mutants
M Xu, DF Covey, MH Akabas
Biophysical journal 69 (5), 1858-1867, 1995
1791995
Mechanisms of neurosteroid interactions with GABAA receptors
G Akk, DF Covey, AS Evers, JH Steinbach, CF Zorumski, S Mennerick
Pharmacology & therapeutics 116 (1), 35-57, 2007
1772007
Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann–Pick C disease
SJ Langmade, SE Gale, A Frolov, I Mohri, K Suzuki, SH Mellon, ...
Proceedings of the National Academy of Sciences 103 (37), 13807-13812, 2006
1772006
Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
S Nachtergaele, DM Whalen, LK Mydock, Z Zhao, T Malinauskas, ...
elife 2, e01340, 2013
1762013
3β-hydroxypregnane steroids are pregnenolone sulfate-like GABAA receptor antagonists
M Wang, Y He, LN Eisenman, C Fields, CM Zeng, J Mathews, A Benz, ...
Journal of Neuroscience 22 (9), 3366-3375, 2002
1752002
10 beta-propynyl-substituted steroids. Mechanism-based enzyme-activated irreversible inhibitors of estrogen biosynthesis.
DF Covey, WF Hood, VD Parikh
Journal of Biological Chemistry 256 (3), 1076-1079, 1981
1731981
Cholesterol depletion results in site-specific increases in epidermal growth factor receptor phosphorylation due to membrane level effects: studies with cholesterol enantiomers
EJ Westover, DF Covey, HL Brockman, RE Brown, LJ Pike
Journal of Biological Chemistry 278 (51), 51125-51133, 2003
1712003
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