| Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite G Cerutti, Y Guo, T Zhou, J Gorman, M Lee, M Rapp, ER Reddem, J Yu, ... Cell host & microbe 29 (5), 819-833. e7, 2021 | 455 | 2021 |
| An artificial heme enzyme for cyclopropanation reactions L Villarino, KE Splan, E Reddem, L Alonso‐Cotchico, ... Angewandte Chemie International Edition 57 (26), 7785-7789, 2018 | 106 | 2018 |
| Directed evolution of a designer enzyme featuring an unnatural catalytic amino acid C Mayer, C Dulson, E Reddem, AMWH Thunnissen, G Roelfes Angewandte Chemie International Edition 58 (7), 2083-2087, 2019 | 82 | 2019 |
| Explaining operational instability of amine transaminases: substrate-induced inactivation mechanism and influence of quaternary structure on enzyme–cofactor intermediate stability T Börner, S Rämisch, ER Reddem, S Bartsch, A Vogel, ... Acs Catalysis 7 (2), 1259-1269, 2017 | 67 | 2017 |
| Novel binding studies of human serum albumin with trans feruloyl maslinic acid ADG Subramanyam R1, Goud M, Sudhamalla B, Reddem E, Gollapudi A, Nellaepalli ... J Photochem Photobiol B 95 (2), 81-88, 2009 | 62 | 2009 |
| Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class M Rapp, Y Guo, ER Reddem, J Yu, L Liu, P Wang, G Cerutti, P Katsamba, ... Cell Reports 35 (1), 2021 | 59 | 2021 |
| Structural basis for accommodation of emerging B. 1.351 and B. 1.1. 7 variants by two potent SARS-CoV-2 neutralizing antibodies G Cerutti, M Rapp, Y Guo, F Bahna, J Bimela, ER Reddem, J Yu, P Wang, ... Structure 29 (7), 655-663. e4, 2021 | 58 | 2021 |
| Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain G Cerutti, Y Guo, P Wang, MS Nair, M Wang, Y Huang, J Yu, L Liu, ... Cell reports 37 (5), 2021 | 50 | 2021 |
| Paired heavy-and light-chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses BB Banach, G Cerutti, AS Fahad, CH Shen, MO De Souza, PS Katsamba, ... Cell Reports 37 (1), 2021 | 46 | 2021 |
| An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses L Liu, S Iketani, Y Guo, ER Reddem, RG Casner, MS Nair, J Yu, ... Science translational medicine 14 (646), eabn6859, 2022 | 33 | 2022 |
| Structure and RNA template requirements of Arabidopsis RNA-DEPENDENT RNA POLYMERASE 2 A Fukudome, J Singh, V Mishra, E Reddem, F Martinez-Marquez, ... Proceedings of the National Academy of Sciences 118 (51), e2115899118, 2021 | 26 | 2021 |
| Cofactor binding dynamics influence the catalytic activity and selectivity of an artificial metalloenzyme L Villarino, S Chordia, L Alonso-Cotchico, E Reddem, Z Zhou, ... ACS catalysis 10 (20), 11783-11790, 2020 | 26 | 2020 |
| Identification of a 1-deoxy-D-xylulose-5-phosphate synthase (DXS) mutant with improved crystallographic properties RM Gierse, ER Reddem, A Alhayek, D Baitinger, Z Hamid, H Jakobi, ... Biochemical and Biophysical Research Communications 539, 42-47, 2021 | 12 | 2021 |
| DXS as a target for structure-based drug design RM Gierse, E Redeem, E Diamanti, C Wrenger, MR Groves, AKH Hirsch Future Medicinal Chemistry 9 (11), 1277-1294, 2017 | 12 | 2017 |
| Antibodies that neutralize all current SARS-CoV-2 variants of concern by conformational locking L Liu, RG Casner, Y Guo, Q Wang, S Iketani, JFW Chan, J Yu, ... bioRxiv, 2023.04. 08.536123, 2023 | 9 | 2023 |
| First crystal structures of 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate … RM Gierse, R Oerlemans, ER Reddem, VO Gawriljuk, A Alhayek, ... Scientific Reports 12 (1), 7221, 2022 | 9 | 2022 |
| Isolation and comparative analysis of antibodies that broadly neutralize sarbecoviruses L Liu, S Iketani, Y Guo, RG Casner, ER Reddem, MS Nair, J Yu, ... bioRxiv, 2021.12. 11.472236, 2021 | 6 | 2021 |
| Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking L Liu, RG Casner, Y Guo, Q Wang, S Iketani, JFW Chan, J Yu, ... Immunity 56 (10), 2442-2455. e8, 2023 | 5 | 2023 |
| Structural insights into broadly neutralizing antibodies elicited by hybrid immunity against SARS-CoV-2 M Luo, B Zhou, ER Reddem, B Tang, B Chen, R Zhou, H Liu, L Liu, ... Emerging Microbes & Infections 12 (1), 2146538, 2023 | 4 | 2023 |
| Identifying a molecular mechanism that imparts species-specific toxicity to YoeB toxins JR Ames, J McGillick, T Murphy, E Reddem, CR Bourne Frontiers in Microbiology 11, 959, 2020 | 4 | 2020 |
Lawrence ShapiroProfessor of Biochemistry, Columbia UniversityVerified email at columbia.edu
