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Pierre Santucci
Pierre Santucci
LISM - CNRS Aix Marseille Université
Adresse e-mail validée de imm.cnrs.fr
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Experimental models of foamy macrophages and approaches for dissecting the mechanisms of lipid accumulation and consumption during dormancy and reactivation of tuberculosis
P Santucci, F Bouzid, N Smichi, I Poncin, L Kremer, C De Chastellier, ...
Frontiers in cellular and infection microbiology 6, 122, 2016
592016
Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide
P Santucci, DJ Greenwood, A Fearns, K Chen, H Jiang, MG Gutierrez
Nature Communications 12 (1), 3816, 2021
462021
M. tuberculosis infection of human iPSC-derived macrophages reveals complex membrane dynamics during xenophagy evasion
EM Bernard, A Fearns, C Bussi, P Santucci, CJ Peddie, RJ Lai, ...
Journal of cell science 134 (5), jcs252973, 2021
392021
Nitrogen deprivation induces triacylglycerol accumulation, drug tolerance and hypervirulence in mycobacteria
P Santucci, MD Johansen, V Point, I Poncin, A Viljoen, JF Cavalier, ...
Scientific reports 9 (1), 8667, 2019
372019
Cyclophostin and Cyclipostins analogues, new promising molecules to treat mycobacterial-related diseases
PC Nguyen, A Madani, P Santucci, BP Martin, RR Paudel, S Delattre, ...
International journal of antimicrobial agents 51 (4), 651-654, 2018
292018
Delineating the physiological roles of the PE and catalytic domains of LipY in lipid consumption in Mycobacterium-infected foamy macrophages
P Santucci, S Diomandé, I Poncin, L Alibaud, A Viljoen, L Kremer, ...
Infection and immunity 86 (9), 10.1128/iai. 00394-18, 2018
272018
LipG a bifunctional phospholipase/thioesterase involved in mycobacterial envelope remodeling
P Santucci, V Point, I Poncin, A Guy, C Crauste, C Serveau-Avesque, ...
Bioscience reports 38 (6), BSR20181953, 2018
262018
Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism
C Bussi, T Heunis, E Pellegrino, EM Bernard, N Bah, MS Dos Santos, ...
Nature Communications 13 (1), 7338, 2022
162022
ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages
B Aylan, EM Bernard, E Pellegrino, L Botella, A Fearns, N Athanasiadi, ...
Nature Microbiology 8 (5), 803-818, 2023
152023
Intrabacterial lipid inclusions in mycobacteria: unexpected key players in survival and pathogenesis?
I Mallick, P Santucci, I Poncin, V Point, L Kremer, JF Cavalier, S Canaan
FEMS Microbiology Reviews 45 (6), fuab029, 2021
152021
Synthesis of long‐chain β‐lactones and their antibacterial activities against pathogenic mycobacteria
P Santucci, C Dedaki, A Athanasoulis, L Gallorini, A Munoz, S Canaan, ...
ChemMedChem 14 (3), 349-358, 2019
142019
Dissecting the membrane lipid binding properties and lipase activity of Mycobacterium tuberculosis LipY domains
P Santucci, N Smichi, S Diomandé, I Poncin, V Point, H Gaussier, ...
The FEBS journal 286 (16), 3164-3181, 2019
132019
Visualizing Pyrazinamide Action by Live Single-Cell Imaging of Phagosome Acidification and Mycobacterium tuberculosis pH Homeostasis
P Santucci, B Aylan, L Botella, EM Bernard, C Bussi, E Pellegrino, ...
Mbio 13 (2), e00117-22, 2022
112022
Experimental Evolution of Mycobacterium tuberculosis in Human Macrophages Results in Low-Frequency Mutations Not Associated with Selective Advantage
V Guerrini, S Subbian, P Santucci, S Canaan, ML Gennaro, G Pozzi
PloS one 11 (12), e0167989, 2016
82016
Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages
E Pellegrino, B Aylan, C Bussi, A Fearns, EM Bernard, N Athanasiadi, ...
Journal of Cell Biology 222 (12), 2023
62023
High content quantitative imaging of Mycobacterium tuberculosis responses to acidic microenvironments within human macrophages
B Aylan, L Botella, MG Gutierrez, P Santucci
FEBS Open Bio 13 (7), 1204-1217, 2023
32023
Intracellular pathogens, membrane damage and cytosolic access
P Santucci
Cellular Microbiology 23 (4), e13296, 2021
32021
Lipid droplets breakdown: adipose triglyceride lipase leads the way
P Santucci, S Canaan
Current Protein and Peptide Science 19 (11), 1131-1133, 2018
32018
Activity and Crystal Structure of the Adherent-Invasive Escherichia coli Tle3/Tli3 T6SS Effector/Immunity Complex Determined Using an AlphaFold2 Predicted Model
TTH Le, C Kellenberger, M Boyer, P Santucci, N Flaugnatti, E Cascales, ...
International Journal of Molecular Sciences 24 (2), 1740, 2023
22023
Host cell environments and antibiotic efficacy in tuberculosis
NJ Day, P Santucci, MG Gutierrez
Trends in Microbiology, 2023
12023
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