| COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets TM Delorey, CGK Ziegler, G Heimberg, R Normand, Y Yang, ... Nature 595 (7865), 107-113, 2021 | 595 | 2021 |
| Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans A Omenetti, A Porrello, Y Jung, L Yang, Y Popov, SS Choi, RP Witek, ... The Journal of clinical investigation 118 (10), 3331-3342, 2008 | 441 | 2008 |
| Targeting liver fibrosis: strategies for development and validation of antifibrotic therapies Y Popov, D Schuppan Hepatology 50 (4), 1294-1306, 2009 | 381 | 2009 |
| Mdr2 (Abcb4)-/-mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro-and antifibrogenic genes Y Popov, E Patsenker, P Fickert, M Trauner, D Schuppan Journal of hepatology 43 (6), 1045-1054, 2005 | 302 | 2005 |
| Vascular endothelial growth factor promotes fibrosis resolution and repair in mice L Yang, J Kwon, Y Popov, GB Gajdos, T Ordog, RA Brekken, ... Gastroenterology 146 (5), 1339-1350. e1, 2014 | 280 | 2014 |
| Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets FM Fisher, PC Chui, IA Nasser, Y Popov, JC Cunniff, T Lundasen, ... Gastroenterology 147 (5), 1073-1083. e6, 2014 | 263 | 2014 |
| Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal PYV Ikenaga N, Peng ZW, Vaid KA, Liu SB, Yoshida S, Sverdlov DY, Mikels ... Gut, 2017 | 258 | 2017 |
| Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease GA Kwong, G Von Maltzahn, G Murugappan, O Abudayyeh, S Mo, ... Nature biotechnology 31 (1), 63-70, 2013 | 236 | 2013 |
| Inhibition of integrin αvβ6 on cholangiocytes blocks transforming growth factor-β activation and retards biliary fibrosis progression E Patsenker, Y Popov, F Stickel, A Jonczyk, SL Goodman, D Schuppan Gastroenterology 135 (2), 660-670, 2008 | 234 | 2008 |
| Lysyl oxidase activity contributes to collagen stabilization during liver fibrosis progression and limits spontaneous fibrosis reversal in mice SB Liu, N Ikenaga, ZW Peng, DY Sverdlov, A Greenstein, V Smith, ... The FASEB Journal 30 (4), 1599-1609, 2016 | 221 | 2016 |
| Pharmacological inhibition of integrin αvβ3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis E Patsenker, Y Popov, F Stickel, V Schneider, M Ledermann, H Sägesser, ... Hepatology 50 (5), 1501-1511, 2009 | 211 | 2009 |
| Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis P An, LL Wei, S Zhao, DY Sverdlov, KA Vaid, M Miyamoto, K Kuramitsu, ... Nature communications 11 (1), 2362, 2020 | 207 | 2020 |
| Integrin αvβ6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies Y Popov, E Patsenker, F Stickel, J Zaks, KR Bhaskar, G Niedobitek, ... Journal of hepatology 48 (3), 453-464, 2008 | 203 | 2008 |
| Hepatitis C virus-replicating hepatocytes induce fibrogenic activation of hepatic stellate cells A Schulze-Krebs, D Preimel, Y Popov, R Bartenschlager, V Lohmann, ... Gastroenterology 129 (1), 246-258, 2005 | 197 | 2005 |
| Tissue transglutaminase does not affect fibrotic matrix stability or regression of liver fibrosis in mice Y Popov, DY Sverdlov, AK Sharma, KR Bhaskar, S Li, TL Freitag, J Lee, ... Gastroenterology 140 (5), 1642-1652, 2011 | 160 | 2011 |
| Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis Y Popov, DY Sverdlov, KR Bhaskar, AK Sharma, G Millonig, E Patsenker, ... American Journal of Physiology-Gastrointestinal and Liver Physiology 298 (3 …, 2010 | 152 | 2010 |
| The hedgehog pathway regulates remodelling responses to biliary obstruction in rats A Omenetti, Y Popov, Y Jung, SS Choi, RP Witek, L Yang, KD Brown, ... Gut 57 (9), 1275-1282, 2008 | 150 | 2008 |
| Extrahepatic platelet-derived growth factor-β, delivered by platelets, promotes activation of hepatic stellate cells and biliary fibrosis in mice S Yoshida, N Ikenaga, SB Liu, ZW Peng, J Chung, DY Sverdlov, ... Gastroenterology 147 (6), 1378-1392, 2014 | 147 | 2014 |
| Failure of fibrotic liver regeneration in mice is linked to a severe fibrogenic response driven by hepatic progenitor cell activation K Kuramitsu, DY Sverdlov, SB Liu, E Csizmadia, L Burkly, D Schuppan, ... The American journal of pathology 183 (1), 182-194, 2013 | 139 | 2013 |
| Human T cell microparticles circulate in blood of hepatitis patients and induce fibrolytic activation of hepatic stellate cells M Kornek, Y Popov, TA Libermann, NH Afdhal, D Schuppan Hepatology 53 (1), 230-242, 2011 | 136 | 2011 |
Detlef SchuppanProfessor of Medicine Mainz University Medical Center, Germany, and Harvard Medical School, Boston, MAVerified email at bidmc.harvard.edu
