| Lipopolysaccharide primes the NALP3 inflammasome by inhibiting its ubiquitination and degradation mediated by the SCFFBXL2 E3 ligase SH Han, TB Lear, JA Jerome, S Rajbhandari, CA Snavely, DL Gulick, ... Journal of Biological Chemistry 290 (29), 18124-18133, 2015 | 171 | 2015 |
| F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7 Y Liu, T Lear, Y Zhao, J Zhao, C Zou, BB Chen, RK Mallampalli Cell death & disease 6 (2), e1630-e1630, 2015 | 68 | 2015 |
| The proapoptotic F-box protein Fbxl7 regulates mitochondrial function by mediating the ubiquitylation and proteasomal degradation of survivin Y Liu, T Lear, O Iannone, S Shiva, C Corey, S Rajbhandari, J Jerome, ... Journal of Biological Chemistry 290 (19), 11843-11852, 2015 | 63 | 2015 |
| A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry Y Chen, TB Lear, JW Evankovich, MB Larsen, B Lin, I Alfaras, ... Nature communications 12 (1), 3907, 2021 | 52 | 2021 |
| E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin synthase 1 stability and mitochondrial function in pneumonia BB Chen, TA Coon, JR Glasser, C Zou, B Ellis, T Das, AC McKelvey, ... Cell reports 7 (2), 476-487, 2014 | 52 | 2014 |
| The proinflammatory role of HECTD2 in innate immunity and experimental lung injury TA Coon, AC McKelvey, T Lear, S Rajbhandari, SR Dunn, W Connelly, ... Science translational medicine 7 (295), 295ra109-295ra109, 2015 | 46 | 2015 |
| Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1 Y Liu, TB Lear, M Verma, KZQ Wang, PA Otero, AC McKelvey, SR Dunn, ... JCI insight 5 (11), 2020 | 43 | 2020 |
| Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4 T Lear, AC McKelvey, S Rajbhandari, SR Dunn, TA Coon, W Connelly, ... Journal of Experimental Medicine 213 (6), 1029-1046, 2016 | 34 | 2016 |
| Post-translational modification of the interferon-gamma receptor alters its stability and signaling JD Londino, DL Gulick, TB Lear, TL Suber, NM Weathington, LS Masa, ... Biochemical Journal 474 (20), 3543-3557, 2017 | 31 | 2017 |
| The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing TB Lear, KC Lockwood, Y Ouyang, JW Evankovich, MB Larsen, B Lin, ... Journal of Biological Chemistry 294 (45), 16527-16534, 2019 | 22 | 2019 |
| The RNFT2/IL-3Rα axis regulates IL-3 signaling and innate immunity Y Tong, TB Lear, J Evankovich, Y Chen, JD Londino, MM Myerburg, ... JCI insight 5 (3), 2020 | 21 | 2020 |
| RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity AC McKelvey, TB Lear, SR Dunn, J Evankovich, JD Londino, JS Bednash, ... Elife 5, e18496, 2016 | 21 | 2016 |
| Novel PDE4 inhibitors derived from Chinese medicine forsythia TA Coon, AC McKelvey, NM Weathington, RL Birru, T Lear, GD Leikauf, ... PloS one 9 (12), e115937, 2014 | 21 | 2014 |
| Receptor for advanced glycation end products is targeted by FBXO10 for ubiquitination and degradation J Evankovich, T Lear, A Mckelvey, S Dunn, J Londino, Y Liu, BB Chen, ... The FASEB Journal 31 (9), 3894, 2017 | 20 | 2017 |
| Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis TB Lear, KC Lockwood, M Larsen, F Tuncer, JR Kennerdell, C Morse, ... Journal of Biological Chemistry 295 (13), 4171-4180, 2020 | 16 | 2020 |
| A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance Y Liu, MJ Jurczak, TB Lear, B Lin, MB Larsen, JR Kennerdell, Y Chen, ... Nature chemical biology 17 (3), 298-306, 2021 | 15 | 2021 |
| KIAA0317 regulates pulmonary inflammation through SOCS2 degradation TB Lear, AC McKelvey, JW Evankovich, S Rajbhandari, TA Coon, ... JCI insight 4 (19), 2019 | 15 | 2019 |
| RING finger protein 113A regulates CXC chemokine receptor type 4 stability and signaling T Lear, SR Dunn, AC McKelvey, A Mir, J Evankovich, BB Chen, Y Liu American Journal of Physiology-Cell Physiology 313 (5), C584-C592, 2017 | 15 | 2017 |
| A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis Y Chen, JW Evankovich, TB Lear, F Tuncer, JR Kennerdell, DP Camarco, ... Redox Biology 32, 101485, 2020 | 14 | 2020 |
| Toll-like receptor 8 stability is regulated by ring finger 216 in response to circulating microRNAs J Evankovich, T Lear, C Baldwin, Y Chen, V White, J Villandre, J Londino, ... American journal of respiratory cell and molecular biology 62 (2), 157-167, 2020 | 14 | 2020 |
John EvankovichUniversity of Pittsburgh School of MedicineVerified email at upmc.edu
