| Aglycosylated IgG variants expressed in bacteria that selectively bind FcγRI potentiate tumor cell killing by monocyte-dendritic cells ST Jung, ST Reddy, TH Kang, MJ Borrok, I Sandlie, PW Tucker, ... Proceedings of the National Academy of Sciences 107 (2), 604-609, 2010 | 174 | 2010 |
| Revisiting the role of glycosylation in the structure of human IgG Fc MJ Borrok, ST Jung, TH Kang, AF Monzingo, G Georgiou ACS chemical biology 7 (9), 1596-1602, 2012 | 163 | 2012 |
| IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions CH Lee, G Romain, W Yan, M Watanabe, W Charab, B Todorova, J Lee, ... Nature immunology 18 (8), 889-898, 2017 | 135 | 2017 |
| Bypassing glycosylation: engineering aglycosylated full-length IgG antibodies for human therapy ST Jung, TH Kang, W Kelton, G Georgiou Current opinion in biotechnology 22 (6), 858-867, 2011 | 135 | 2011 |
| Boosting therapeutic potency of antibodies by taming Fc domain functions TH Kang, ST Jung Experimental & molecular medicine 51 (11), 1-9, 2019 | 118 | 2019 |
| Effective phagocytosis of low Her2 tumor cell lines with engineered, aglycosylated IgG displaying high FcγRIIa affinity and selectivity ST Jung, W Kelton, TH Kang, DTW Ng, JT Andersen, I Sandlie, CA Sarkar, ... ACS chemical biology 8 (2), 368-375, 2013 | 82 | 2013 |
| Comprehensive engineering of Escherichia coli for enhanced expression of IgG antibodies T Makino, G Skretas, TH Kang, G Georgiou Metabolic engineering 13 (2), 241-251, 2011 | 74 | 2011 |
| IgGA: a “cross-isotype” engineered human Fc antibody domain that displays both IgG-like and IgA-like effector functions W Kelton, N Mehta, W Charab, J Lee, C Lee, T Kojima, TH Kang, ... Chemistry & biology 21 (12), 1603-1609, 2014 | 70 | 2014 |
| Protein solubility and folding enhancement by interaction with RNA SI Choi, KS Han, CW Kim, KS Ryu, BH Kim, KH Kim, SI Kim, TH Kang, ... PloS one 3 (7), e2677, 2008 | 70 | 2008 |
| Solubility, stability, and avidity of recombinant antibody fragments expressed in microorganisms TH Kang, BL Seong Frontiers in microbiology 11, 552011, 2020 | 67 | 2020 |
| An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence CH Lee, TH Kang, O Godon, M Watanabe, G Delidakis, CM Gillis, ... Nature communications 10 (1), 5031, 2019 | 64 | 2019 |
| An Engineered Human Fc variant With Exquisite Selectivity for FcγRIIIaV158 Reveals That Ligation of FcγRIIIa Mediates Potent Antibody Dependent Cellular … TH Kang, CH Lee, G Delidakis, J Jung, O Richard-Le Goff, J Lee, JE Kim, ... Frontiers in Immunology 10, 562, 2019 | 22 | 2019 |
| Efficient expression and purification of human aglycosylated Fcγ receptors in Escherichia coli ST Jung, TH Kang, G Georgiou Biotechnology and bioengineering 107 (1), 21-30, 2010 | 20 | 2010 |
| Engineering an aglycosylated Fc variant for enhanced FcγRI engagement and pH-dependent human FcRn binding ST Jung, TH Kang, D Kim Biotechnology and bioprocess engineering 19, 780-789, 2014 | 18 | 2014 |
| Computer‐based engineering of thermostabilized antibody fragments J Lee, BS Der, CS Karamitros, W Li, NM Marshall, OI Lungu, AE Miklos, ... AIChE Journal 66 (3), e16864, 2020 | 15 | 2020 |
| Reprogramming the constant region of immunoglobulin G subclasses for enhanced therapeutic potency against cancer TH Kang, ST Jung Biomolecules 10 (3), 382, 2020 | 10 | 2020 |
| Engineered immunoglobulin FC polypeptides G Georgiou, ST Jung, W Kelton, TH Kang US Patent 8,952,132, 2015 | 9 | 2015 |
| Fc receptor variants and disease: a crucial factor to consider in the antibody therapeutics in clinic J Kim, JY Lee, HG Kim, MW Kwak, TH Kang International Journal of Molecular Sciences 22 (17), 9489, 2021 | 7 | 2021 |
| Correction: corrigendum: IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions CH Lee, G Romain, W Yan, M Watanabe, W Charab, B Todorova, J Lee, ... Nature Immunology 18 (10), 1173-1173, 2017 | 4 | 2017 |
| Accelerating Antibody Design with Active Learning S Seo, MW Kwak, E Kang, C Kim, E Park, TH Kang, J Kim BioRxiv, 2022.09. 12.507690, 2022 | 3 | 2022 |
