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Lace M. Riggs
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Ketamine and ketamine metabolite pharmacology: Insights into therapeutic mechanisms
P Zanos, R Moaddel, PJ Morris, LM Riggs, JN Highland, P Georgiou, ...
Pharmacological Reviews 70 (3), 621-660, 2018
9332018
Social defeat stress induces a depression-like phenotype in adolescent male C57BL/6 mice
SD Iñiguez, LM Riggs, SJ Nieto, G Dayrit, NN Zamora, KL Shawhan, ...
Stress 17 (3), 247-255, 2014
2902014
Vicarious social defeat stress induces depression-related outcomes in female mice
SD Iñiguez, FJ Flores-Ramirez, LM Riggs, JB Alipio, I Garcia-Carachure, ...
Biological Psychiatry 83 (1), 9-17, 2018
1752018
Social defeat stress induces depression-like behavior and alters spine morphology in the hippocampus of adolescent male C57BL/6 mice
SD Iñiguez, A Aubry, LM Riggs, JB Alipio, RM Zanca, FJ Flores-Ramirez, ...
Neurobiology of Stress 5, 54-64, 2016
1142016
Drp1 mitochondrial fission in D1 neurons mediates behavioral and cellular plasticity during early cocaine abstinence
R Chandra, M Engeln, C Schiefer, MH Patton, JA Martin, CT Werner, ...
Neuron 96 (6), 1327-1341. e6, 2017
762017
Mechanisms of ketamine and its metabolites as antidepressants
EM Hess, LM Riggs, M Michaelides, TD Gould
Biochemical Pharmacology, 114892, 2021
742021
Hydroxynorketamines: Pharmacology and potential therapeutic applications
JN Highland, P Zanos, LM Riggs, P Georgiou, SM Clark, PJ Morris, ...
Pharmacological Reviews 73 (2), 763-791, 2021
622021
Fluoxetine exposure during adolescence alters responses to aversive stimuli in adulthood
SD Iniguez, LF Alcantara, BL Warren, LM Riggs, EM Parise, V Vialou, ...
Journal of Neuroscience 34 (3), 1007-1021, 2014
622014
Ketamine and the future of rapid-acting antidepressants
LM Riggs, TD Gould
Annual Review of Clinical Psychology 17, 207-231, 2021
532021
(2R,6R)-hydroxynorketamine rapidly potentiates hippocampal glutamatergic transmission through a synapse-specific presynaptic mechanism
LM Riggs, Y Aracava, P Zanos, J Fischell, EX Albuquerque, EFR Pereira, ...
Neuropsychopharmacology 45 (2), 426–436, 2020
392020
Reduced Slc6a15 in nucleus accumbens D2-neurons underlies stress susceptibility
R Chandra, TC Francis, H Nam, LM Riggs, M Engeln, S Rudzinskas, ...
Journal of Neuroscience 37 (27), 6527-6538, 2017
392017
Fluoxetine exposure during adolescence increases preference for cocaine in adulthood
SD Iñiguez, LM Riggs, SJ Nieto, KN Wright, NN Zamora, B Cruz, ...
Scientific Reports 5, 15009, 2015
222015
Hydroxynorketamine pharmacokinetics and antidepressant behavioral effects of (2,6)- and (5,R)-methyl-(2R,6R)-hydroxynorketamines
JN Highland, PJ Morris, KM Konrath, LM Riggs, NR Hagen, P Zanos, ...
ACS Chemical Neuroscience, 2022
142022
(R,S)-ketamine and (2R,6R)-hydroxynorketamine differentially affect memory as a function of dosing frequency
LM Riggs, X An, EFR Pereira, TD Gould
Translational Psychiatry 11, 1-12, 2021
112021
Environmental enrichment mitigates the long-lasting sequelae of perinatal fentanyl exposure in mice
JB Alipio*, LM Riggs*, M Plank, A Keller
Journal of Neuroscience, 2022
92022
Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder
N Hasin, LM Riggs, T Shekhtman, J Ashworth, R Lease, RT Oshone, ...
Molecular Psychiatry, 2022
8*2022
(2R,6R)-hydroxynorketamine rapidly potentiates optically-evoked Schaffer collateral synaptic activity
LM Riggs, SM Thompson, TD Gould
Neuropharmacology, 2022
82022
cAMP-dependent protein kinase signaling is required for (2R,6R)-hydroxynorketamine to potentiate hippocampal glutamatergic transmission
LM Riggs, EFR Pereira, SM Thompson, TD Gould
Journal of Neurophysiology 131 (1), 64-74, 2024
2024
Synaptic mechanisms underlying the rapid antidepressant properties of the (2R,6R)-hydroxynorketamine ketamine metabolite
LM Riggs
PhD Dissertation, University of Maryland School of Medicine, Baltimore, MD, 2021
2021
Ketamine exposure during adolescence increases sensitivity to reward-related stimuli in adulthood
LM Riggs
California State University, San Bernardino, CA, 2016
2016
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Articles 1–20