Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception D Africander, N Verhoog, JP Hapgood Steroids 76 (7), 636-652, 2011 | 311 | 2011 |
11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: a putative role in castration resistant prostate cancer? KH Storbeck, LM Bloem, D Africander, L Schloms, P Swart, AC Swart Molecular and cellular endocrinology 377 (1-2), 135-146, 2013 | 190 | 2013 |
11-Ketotestosterone and 11-ketodihydrotestosterone in castration resistant prostate cancer: potent androgens which can no longer be ignored E Pretorius, DJ Africander, M Vlok, MS Perkins, J Quanson, KH Storbeck PloS one 11 (7), e0159867, 2016 | 144 | 2016 |
Potency of progestogens used in hormonal therapy: toward understanding differential actions JP Hapgood, D Africander, R Louw, RM Ray, JM Rohwer The Journal of steroid biochemistry and molecular biology 142, 39-47, 2014 | 109 | 2014 |
Abrogation of glucocorticoid receptor dimerization correlates with dissociated glucocorticoid behavior of compound a S Robertson, F Allie-Reid, WV Berghe, K Visser, A Binder, D Africander, ... Journal of Biological Chemistry 285 (11), 8061-8075, 2010 | 98 | 2010 |
Comparing the androgenic and estrogenic properties of progestins used in contraception and hormone therapy R Louw-du Toit, MS Perkins, JP Hapgood, D Africander Biochemical and biophysical research communications 491 (1), 140-146, 2017 | 80 | 2017 |
The injectable-only contraceptive medroxyprogesterone acetate, unlike norethisterone acetate and progesterone, regulates inflammatory genes in endocervical cells via the … Y Govender, C Avenant, NJD Verhoog, RM Ray, NJ Grantham, ... PloS one 9 (5), e96497, 2014 | 79 | 2014 |
Differential regulation of endogenous pro-inflammatory cytokine genes by medroxyprogesterone acetate and norethisterone acetate in cell lines of the female genital tract D Africander, R Louw, N Verhoog, D Noeth, JP Hapgood Contraception 84 (4), 423-435, 2011 | 73 | 2011 |
Not all progestins are the same: implications for usage JP Hapgood, D Koubovec, A Louw, D Africander Trends in pharmacological sciences 25 (11), 554-557, 2004 | 69 | 2004 |
A comparative study of the androgenic properties of progesterone and the progestins, medroxyprogesterone acetate (MPA) and norethisterone acetate (NET-A) DJ Africander, KH Storbeck, JP Hapgood The Journal of steroid biochemistry and molecular biology 143, 404-415, 2014 | 62 | 2014 |
Steroid metabolism in breast cancer: Where are we and what are we missing? D Africander, KH Storbeck Molecular and Cellular Endocrinology 466, 86-97, 2018 | 43 | 2018 |
Medroxyprogesterone acetate differentially regulates interleukin (IL)-12 and IL-10 in a human ectocervical epithelial cell line in a glucocorticoid receptor (GR)-dependent manner R Louw-du Toit, JP Hapgood, D Africander Journal of Biological Chemistry 289 (45), 31136-31149, 2014 | 40 | 2014 |
Investigating the anti-mineralocorticoid properties of synthetic progestins used in hormone therapy D Africander, R Louw, JP Hapgood Biochemical and biophysical research communications 433 (3), 305-310, 2013 | 40 | 2013 |
A comparative characterization of estrogens used in hormone therapy via estrogen receptor (ER)-α and-β MS Perkins, R Louw-du Toit, D Africander The Journal of Steroid Biochemistry and Molecular Biology 174, 27-39, 2017 | 37 | 2017 |
Hormone therapy and breast cancer: emerging steroid receptor mechanisms MS Perkins, R Louw-du Toit, D Africander Journal of Molecular Endocrinology 61 (4), R133-R160, 2018 | 28 | 2018 |
16α-hydroxyprogesterone: origin, biosynthesis and receptor interaction KH Storbeck, P Swart, D Africander, R Conradie, R Louw, AC Swart Molecular and cellular endocrinology 336 (1-2), 92-101, 2011 | 28 | 2011 |
Pharmacokinetics, metabolism and serum concentrations of progestins used in contraception AJ Bick, R Louw-du Toit, SB Skosana, D Africander, JP Hapgood Pharmacology & therapeutics 222, 107789, 2021 | 27 | 2021 |
11-Oxygenated estrogens are a novel class of human estrogens but do not contribute to the circulating estrogen pool L Barnard, L Schiffer, R Louw du-Toit, JA Tamblyn, S Chen, D Africander, ... Endocrinology 162 (3), bqaa231, 2021 | 25 | 2021 |
Sutherlandia frutescens modulates adrenal hormone biosynthesis, acts as a selective glucocorticoid receptor agonist (SEGRA) and displays anti-mineralocorticoid properties CA Sergeant, D Africander, P Swart, AC Swart Journal of ethnopharmacology 202, 290-301, 2017 | 18 | 2017 |
Progestins used in endocrine therapy and the implications for the biosynthesis and metabolism of endogenous steroid hormones R Louw-du Toit, KH Storbeck, M Cartwright, A Cabral, D Africander Molecular and cellular endocrinology 441, 31-45, 2017 | 16 | 2017 |