| Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1–AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the … TM Penning, ME Burczynski, JM Jez, CF Hung, HK Lin, H Ma, M Moore, ... Biochemical journal 351 (1), 67-77, 2000 | 766 | 2000 |
| Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: generation of reactive and redox active o-quinones TM Penning, ME Burczynski, CF Hung, KD McCoull, NT Palackal, ... Chemical research in toxicology 12 (1), 1-18, 1999 | 564 | 1999 |
| The multifaceted exosome: biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities S Pant, H Hilton, ME Burczynski Biochemical pharmacology 83 (11), 1484-1494, 2012 | 560 | 2012 |
| Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells ME Burczynski, M McMillian, J Ciervo, L Li, JB Parker, RT Dunn, S Hicken, ... Toxicological sciences 58 (2), 399-415, 2000 | 340 | 2000 |
| Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities KD Davis, N Aghaeepour, AH Ahn, MS Angst, D Borsook, A Brenton, ... Nature Reviews Neurology 16 (7), 381-400, 2020 | 281 | 2020 |
| Molecular classification of Crohn's disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cells ME Burczynski, RL Peterson, NC Twine, KA Zuberek, BJ Brodeur, ... The journal of molecular diagnostics 8 (1), 51-61, 2006 | 262 | 2006 |
| Expression profiling of human immune cell subsets identifies miRNA-mRNA regulatory relationships correlated with cell type specific expression F Allantaz, DT Cheng, T Bergauer, P Ravindran, MF Rossier, M Ebeling, ... PloS one 7 (1), e29979, 2012 | 235 | 2012 |
| Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative … ME Burczynski, HK Lin, TM Penning Cancer research 59 (3), 607-614, 1999 | 223 | 1999 |
| Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR‐623, a novel liver X‐receptor agonist, in healthy participants A Katz, C Udata, E Ott, L Hickey, ME Burczynski, P Burghart, O Vesterqvist, ... The Journal of Clinical Pharmacology 49 (6), 643-649, 2009 | 207 | 2009 |
| The reactive oxygen species-and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the α, β-unsaturated aldehyde 4-hydroxy-2-nonenal to 1, 4-dihydroxy-2-nonene ME Burczynski, GR Sridhar, NT Palackal, TM Penning Journal of Biological Chemistry 276 (4), 2890-2897, 2001 | 207 | 2001 |
| Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor ME Burczynski, TM Penning Cancer research 60 (4), 908-915, 2000 | 197 | 2000 |
| Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein γ-secretase for the treatment of Alzheimer's disease RL Martone, H Zhou, K Atchison, T Comery, JZ Xu, X Huang, X Gong, ... Journal of Pharmacology and Experimental Therapeutics 331 (2), 598-608, 2009 | 193 | 2009 |
| Transcriptional profiling of peripheral blood cells in clinical pharmacogenomic studies ME Burczynski, AJ Dorner Future Medicine Ltd 7 (2), 187-202, 2006 | 181 | 2006 |
| Disease-associated expression profiles in peripheral blood mononuclear cells from patients with advanced renal cell carcinoma NC Twine, JA Stover, B Marshall, G Dukart, M Hidalgo, W Stadler, ... Cancer research 63 (18), 6069-6075, 2003 | 178 | 2003 |
| Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7, 8-dihydrobenzo [a] pyrene to the activated o … ME Burczynski, RG Harvey, TM Penning Biochemistry 37 (19), 6781-6790, 1998 | 167 | 1998 |
| Transcriptional profiles in peripheral blood mononuclear cells prognostic of clinical outcomes in patients with advanced renal cell carcinoma ME Burczynski, NC Twine, G Dukart, B Marshall, M Hidalgo, WM Stadler, ... Clinical cancer research 11 (3), 1181-1189, 2005 | 148 | 2005 |
| The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: potential role in polycyclic aromatic hydrocarbon activation NT Palackal, ME Burczynski, RG Harvey, TM Penning Biochemistry 40 (36), 10901-10910, 2001 | 147 | 2001 |
| Structure-function aspects and inhibitor design of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3) TM Penning, ME Burczynski, JM Jez, HK Lin, H Ma, M Moore, K Ratnam, ... Molecular and cellular endocrinology 171 (1-2), 137-149, 2001 | 135 | 2001 |
| Measurement of myostatin concentrations in human serum: circulating concentrations in young and older men and effects of testosterone administration KM Lakshman, S Bhasin, C Corcoran, LA Collins-Racie, L Tchistiakova, ... Molecular and cellular endocrinology 302 (1), 26-32, 2009 | 124 | 2009 |
| Nile Red binding to HepG2 cells: an improved assay for in vitro studies of hepatosteatosis MK McMillian, ER Grant, Z Zhong, JB Parker, L Li, RA Zivin, ... In Vitro & Molecular Toxicology: A Journal of Basic and Applied Research 14 …, 2001 | 120 | 2001 |
