Surfactant protein B (SP-B) enhances the cellular siRNA delivery of proteolipid coated nanogels for inhalation therapy P Merckx, L De Backer, L Van Hoecke, R Guagliardo, M Echaide, ... Acta biomaterialia 78, 236-246, 2018 | 66 | 2018 |
Cationic amphiphilic drugs boost the lysosomal escape of small nucleic acid therapeutics in a nanocarrier-dependent manner T Van de Vyver, B Bogaert, L De Backer, F Joris, R Guagliardo, ... ACS nano 14 (4), 4774-4791, 2020 | 45 | 2020 |
Surfactant protein B promotes cytosolic SiRNA delivery by adopting a virus-like mechanism of action R Guagliardo, L Herman, J Penders, A Zamborlin, H De Keersmaecker, ... ACS nano 15 (5), 8095-8109, 2021 | 26 | 2021 |
Lyophilization and nebulization of pulmonary surfactant-coated nanogels for siRNA inhalation therapy P Merckx, J Lammens, G Nuytten, B Bogaert, R Guagliardo, T Maes, ... European Journal of Pharmaceutics and Biopharmaceutics 157, 191-199, 2020 | 26 | 2020 |
Nanocarrier lipid composition modulates the impact of pulmonary surfactant protein B (SP-B) on cellular delivery of siRNA R Guagliardo, P Merckx, A Zamborlin, L De Backer, M Echaide, ... Pharmaceutics 11 (9), 431, 2019 | 18 | 2019 |
Hydrogel‐Induced Cell Membrane Disruptions Enable Direct Cytosolic Delivery of Membrane‐Impermeable Cargo J Van Hoeck, T Van de Vyver, A Harizaj, G Goetgeluk, P Merckx, J Liu, ... Advanced Materials 33 (30), 2008054, 2021 | 14 | 2021 |
Evaluating β2-agonists as siRNA delivery adjuvants for pulmonary surfactant-coated nanogel inhalation therapy P Merckx, G Conickx, E Blomme, T Maes, KR Bracke, G Brusselle, ... European Journal of Pharmaceutics and Biopharmaceutics 197, 114223, 2024 | | 2024 |
Screening a drug repurposing library for adjuvants that induce lysosomal siRNA escape in nanogel transfected cells T Van de Vyver, B Bogaert, L De Backer, F Joris, R Guagliardo, ... Old drugs with new tricks: repurposing small molecules to promote lysosomal …, 2020 | | 2020 |
Lung surfactant-hydrogel nanocomposites for pulmonary siRNA delivery: breaching barriers for nanomedicine-based inhalation therapy P Merckx Ghent University, 2020 | | 2020 |
SYNTHESIS, PHYSICOCHEMICAL CHARACTERISATION AND CYTOTOXICITY EVALUATION OF DIFFERENT PGA-PTX CONJUGATES P MERCKX | | |