| Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells SA Head, W Shi, L Zhao, K Gorshkov, K Pasunooti, Y Chen, Z Deng, R Li, ... Proceedings of the National Academy of Sciences 112 (52), E7276-E7285, 2015 | 117 | 2015 |
| Synthesis and quantitative structure− activity relationships of new 2, 5-disubstituted-1, 3, 4-oxadiazoles W Shi, X Qian, R Zhang, G Song Journal of agricultural and food chemistry 49 (1), 124-130, 2001 | 115 | 2001 |
| Itraconazole side chain analogues: structure–activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 … W Shi, BA Nacev, BT Aftab, S Head, CM Rudin, JO Liu Journal of medicinal chemistry 54 (20), 7363-7374, 2011 | 76 | 2011 |
| Simultaneous targeting of NPC1 and VDAC1 by itraconazole leads to synergistic inhibition of mTOR signaling and angiogenesis SA Head, WQ Shi, EJ Yang, BA Nacev, SY Hong, KK Pasunooti, RJ Li, ... ACS chemical biology 12 (1), 174-182, 2017 | 74 | 2017 |
| Synthesis of daunorubicin analogues containing truncated aromatic cores and unnatural monosaccharide residues E Fan, W Shi, TL Lowary The Journal of Organic Chemistry 72 (8), 2917-2928, 2007 | 73 | 2007 |
| Ipomoeassin F binds Sec61α to inhibit protein translocation G Zong, Z Hu, S O’keefe, D Tranter, MJ Iannotti, L Baron, B Hall, ... Journal of the American Chemical Society 141 (21), 8450-8461, 2019 | 64 | 2019 |
| Cytotoxicity and topoisomerase I/II inhibition of glycosylated 2-phenyl-indoles, 2-phenyl-benzo [b] thiophenes and 2-phenyl-benzo [b] furans W Shi, SL Marcus, TL Lowary Bioorganic & medicinal chemistry 19 (1), 603-612, 2011 | 59 | 2011 |
| Impact of absolute stereochemistry on the antiangiogenic and antifungal activities of itraconazole W Shi, BA Nacev, S Bhat, JO Liu ACS medicinal chemistry letters 1 (4), 155-159, 2010 | 54 | 2010 |
| Total Synthesis and Biological Evaluation of Ipomoeassin F and Its Unnatural 11R-Epimer G Zong, E Barber, H Aljewari, J Zhou, Z Hu, Y Du, WQ Shi The Journal of organic chemistry 80 (18), 9279-9291, 2015 | 53 | 2015 |
| Syntheses and insecticidal activities of novel 2-fluorophenyl-5-aryl/cyclopropyl-1, 3, 4-oxadiazoles W Shi, X Qian, G Song, R Zhang, R Li Journal of Fluorine Chemistry 106 (2), 173-179, 2000 | 50 | 2000 |
| Canvass: A crowd-sourced, natural-product screening library for exploring biological space SE Kearney, G Zahoránszky-Kőhalmi, KR Brimacombe, MJ Henderson, ... ACS central science 4 (12), 1727-1741, 2018 | 37 | 2018 |
| An alternative pathway for membrane protein biogenesis at the endoplasmic reticulum S O’keefe, G Zong, KB Duah, LE Andrews, WQ Shi, S High Communications Biology 4 (1), 828, 2021 | 36 | 2021 |
| Synthesis and DNA-binding affinity studies of glycosylated intercalators designed as functional mimics of the anthracycline antibiotics W Shi, RS Coleman, TL Lowary Organic & biomolecular chemistry 7 (18), 3709-3722, 2009 | 35 | 2009 |
| Stereospecific metabolism of itraconazole by CYP3A4: dioxolane ring scission of azole antifungals CC Peng, W Shi, JD Lutz, KL Kunze, JO Liu, WL Nelson, N Isoherranen Drug metabolism and disposition 40 (3), 426-435, 2012 | 34 | 2012 |
| Revealing the pharmacophore of ipomoeassin F through molecular editing G Zong, H Aljewari, Z Hu, WQ Shi Organic letters 18 (7), 1674-1677, 2016 | 32 | 2016 |
| Novel Tetrazole-containing analogues of itraconazole as potent antiangiogenic agents with reduced Cytochrome P450 3A4 inhibition Y Li, KK Pasunooti, RJ Li, W Liu, SA Head, WQ Shi, JO Liu Journal of medicinal chemistry 61 (24), 11158-11168, 2018 | 28 | 2018 |
| Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP) L Bauer, S Ferla, SA Head, S Bhat, KK Pasunooti, WQ Shi, L Albulescu, ... Antiviral Research 156, 55-63, 2018 | 27 | 2018 |
| Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor S O'Keefe, P Roboti, KB Duah, G Zong, H Schneider, WQ Shi, S High Journal of Cell Science 134 (4), jcs257758, 2021 | 26 | 2021 |
| Synergistic contribution of tiglate and cinnamate to cytotoxicity of ipomoeassin F G Zong, L Whisenhunt, Z Hu, WQ Shi The Journal of organic chemistry 82 (9), 4977-4985, 2017 | 23 | 2017 |
| Posttranslational insertion of small membrane proteins by the bacterial signal recognition particle R Steinberg, A Origi, A Natriashvili, P Sarmah, M Licheva, PM Walker, ... PLoS biology 18 (9), e3000874, 2020 | 21 | 2020 |
