| The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Y Kureishi, Z Luo, I Shiojima, A Bialik, D Fulton, DJ Lefer, WC Sessa, ... Nature medicine 6 (9), 1004-1010, 2000 | 1918 | 2000 |
| Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function JW Elrod, JW Calvert, J Morrison, JE Doeller, DW Kraus, L Tao, X Jiao, ... Proceedings of the National Academy of Sciences 104 (39), 15560-15565, 2007 | 1315 | 2007 |
| The MEK1–ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice OF Bueno, LJ De Windt, KM Tymitz, SA Witt, TR Kimball, R Klevitsky, ... The EMBO journal 19 (23), 6341-6350, 2000 | 992 | 2000 |
| Hydrogen sulfide mediates cardioprotection through Nrf2 signaling JW Calvert, S Jha, S Gundewar, JW Elrod, A Ramachandran, CB Pattillo, ... Circulation research 105 (4), 365-374, 2009 | 823 | 2009 |
| Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver MR Duranski, JJM Greer, A Dejam, S Jaganmohan, N Hogg, W Langston, ... The Journal of clinical investigation 115 (5), 1232-1240, 2005 | 804 | 2005 |
| Nitrate and nitrite in biology, nutrition and therapeutics JO Lundberg, MT Gladwin, A Ahluwalia, N Benjamin, NS Bryan, A Butler, ... Nature chemical biology 5 (12), 865-869, 2009 | 783 | 2009 |
| A fluorescent probe for fast and quantitative detection of hydrogen sulfide in blood H Peng, Y Cheng, C Dai, AL King, BL Predmore, DJ Lefer, B Wang Angewandte Chemie 123 (41), 9846-9849, 2011 | 670 | 2011 |
| Oxidative stress and cardiac disease DJ Lefer, DN Granger The American journal of medicine 109 (4), 315-323, 2000 | 663 | 2000 |
| Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium. XL Ma, AS Weyrich, DJ Lefer, AM Lefer Circulation research 72 (2), 403-412, 1993 | 658 | 1993 |
| Time course of endothelial dysfunction and myocardial injury during myocardial ischemia and reperfusion in the cat. PS Tsao, N Aoki, DJ Lefer, G Johnson 3rd, AM Lefer Circulation 82 (4), 1402-1412, 1990 | 639 | 1990 |
| Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid. DS McLeod, DJ Lefer, C Merges, GA Lutty The American journal of pathology 147 (3), 642, 1995 | 630 | 1995 |
| Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer S Shiva, MN Sack, JJ Greer, M Duranski, LA Ringwood, L Burwell, ... The Journal of experimental medicine 204 (9), 2089-2102, 2007 | 628 | 2007 |
| In vivo neutralization of P-selectin protects feline heart and endothelium in myocardial ischemia and reperfusion injury. AS Weyrich, XY Ma, DJ Lefer, KH Albertine, AM Lefer The Journal of clinical investigation 91 (6), 2620-2629, 1993 | 611 | 1993 |
| The role of nitric oxide and cell adhesion molecules on the microcirculation in ischaemia-reperfusion AM Lefer, DJ Lefer Cardiovascular research 32 (4), 743-751, 1996 | 596 | 1996 |
| Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS–mediated signaling JW Calvert, S Gundewar, S Jha, JJM Greer, WH Bestermann, R Tian, ... Diabetes 57 (3), 696-705, 2008 | 505 | 2008 |
| Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease DJ Polhemus, DJ Lefer Circulation research 114 (4), 730-737, 2014 | 493 | 2014 |
| Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure S Gundewar, JW Calvert, S Jha, I Toedt-Pingel, S Yong Ji, D Nunez, ... Circulation research 104 (3), 403-411, 2009 | 490 | 2009 |
| Guidelines for experimental models of myocardial ischemia and infarction ML Lindsey, R Bolli, JM Canty Jr, XJ Du, NG Frangogiannis, S Frantz, ... American Journal of Physiology-Heart and Circulatory Physiology 314 (4 …, 2018 | 476 | 2018 |
| Role of endothelial dysfunction in the pathogenesis of reperfusion injury after myocardial ischemia AM Lefer, PS Tsao, DJ Lefer, XL Ma The FASEB journal 5 (7), 2029-2034, 1991 | 476 | 1991 |
| Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts AM Lefer, B Campbell, YK Shin, R Scalia, R Hayward, DJ Lefer Circulation 100 (2), 178-184, 1999 | 466 | 1999 |
David J. Polhemus MD, PhDThe Johns Hopkins HospitalVerified email at jh.edu
