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Kamil J. Cygan
Kamil J. Cygan
PhD Candidate, Brown University
Verified email at brown.edu - Homepage
Title
Cited by
Cited by
Year
Pathogenic variants that alter protein code often disrupt splicing
R Soemedi, KJ Cygan, CL Rhine, J Wang, C Bulacan, J Yang, ...
Nature genetics 49 (6), 848-855, 2017
1942017
The importance of p53 pathway genetics in inherited and somatic cancer genomes
G Stracquadanio, X Wang, MD Wallace, AM Grawenda, P Zhang, J Hewitt, ...
Nature reviews Cancer 16 (4), 251-265, 2016
1632016
MMSplice: modular modeling improves the predictions of genetic variant effects on splicing
J Cheng, TYD Nguyen, KJ Cygan, MH Çelik, WG Fairbrother, Ž Avsec, ...
Genome biology 20, 1-15, 2019
1602019
RNA-binding proteins: splicing factors and disease
AM Fredericks, KJ Cygan, BA Brown, WG Fairbrother
Biomolecules 5 (2), 893-909, 2015
1012015
Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma
A Magen, P Hamon, N Fiaschi, BY Soong, MD Park, R Mattiuz, E Humblin, ...
Nature medicine 29 (6), 1389-1399, 2023
622023
Hereditary cancer genes are highly susceptible to splicing mutations
CL Rhine, KJ Cygan, R Soemedi, S Maguire, MF Murray, SF Monaghan, ...
PLoS genetics 14 (3), e1007231, 2018
542018
The effects of structure on pre-mRNA processing and stability
R Soemedi, KJ Cygan, CL Rhine, DT Glidden, AJ Taggart, CL Lin, ...
Methods 125, 36-44, 2017
522017
Widespread intra-dependencies in the removal of introns from human transcripts
SW Kim, AJ Taggart, C Heintzelman, KJ Cygan, CG Hull, J Wang, ...
Nucleic Acids Research 45 (16), 9503-9513, 2017
482017
RNA structure replaces the need for U2AF2 in splicing
CL Lin, AJ Taggart, KH Lim, KJ Cygan, L Ferraris, R Creton, YT Huang, ...
Genome research 26 (1), 12-23, 2016
302016
Mutational bias and the protein code shape the evolution of splicing enhancers
S Rong, L Buerer, CL Rhine, J Wang, KJ Cygan, WG Fairbrother
Nature communications 11 (1), 2845, 2020
232020
Changes in the process of alternative RNA splicing results in soluble B and T lymphocyte attenuator with biological and clinical implications in critical illness
SF Monaghan, D Banerjee, CS Chung, J Lomas-Neira, KJ Cygan, ...
Molecular Medicine 24, 1-7, 2018
222018
Future directions for high‐throughput splicing assays in precision medicine
CL Rhine, C Neil, DT Glidden, KJ Cygan, AM Fredericks, J Wang, ...
Human mutation 40 (9), 1225-1234, 2019
172019
Baseline biomarkers of T-cell function correlate with clinical responses to odronextamab (REGN1979), and loss of CD20 target antigen expression identified as a mechanism of …
J Brouwer-Visser, N Fiaschi, RP Deering, A Dhanik, KJ Cygan, W Zhang, ...
Blood 136, 10-11, 2020
112020
Intratumoral mregDC and CXCL13 T helper niches enable local differentiation of CD8 T cells following PD-1 blockade
A Magen, P Hamon, N Fiaschi, L Troncoso, E Humblin, D D’souza, ...
BioRxiv, 2022.06. 22.497216, 2022
82022
Spliceman2: a computational web server that predicts defects in pre-mRNA splicing
KJ Cygan, CH Sanford, WG Fairbrother
Bioinformatics 33 (18), 2943-2945, 2017
82017
Defective splicing of the RB1 transcript is the dominant cause of retinoblastomas
KJ Cygan, R Soemedi, CL Rhine, A Profeta, EL Murphy, MF Murray, ...
Human genetics 136, 1303-1312, 2017
82017
Avsec, žiga, & Gagneur, J.(2019). MMSplice: modular modeling improves the predictions of genetic variant effects on splicing
J Cheng, TYD Nguyen, KJ Cygan, MH Çelik, WG Fairbrother
Genome Biology 20 (1), 48, 0
5
Non-cancer-related pathogenic germline variants and expression consequences in ten-thousand cancer genomes
Z Wang, X Fan, Y Shen, MS Pagadala, R Signer, KJ Cygan, ...
Genome medicine 13, 1-13, 2021
42021
CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods
N Null, S Jain, C Bakolitsa, SE Brenner, P Radivojac, J Moult, S Repo, ...
Genome Biology 25 (1), 1-46, 2024
22024
Clinical responses to odronextamab (regn1979): correlation with loss of cd20 expression as a potential mechanism of resistance and baseline biomarkers of tumor T cells
J Brouwer‐Visser, N Fiaschi, RP Deering, A Dhanik, KJ Cygan, W Zhang, ...
Hematological Oncology 39, 2021
12021
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