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Michael Thomas Klein
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A new approach for studying GPCR dimers: drug-induced inactivation and reactivation to reveal GPCR dimer function in vitro, in primary culture, and in vivo
M Teitler, MT Klein
Pharmacology & therapeutics 133 (2), 205-217, 2012
542012
Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-hydroxytryptamine7 receptor by risperidone, 9-OH-risperidone, and other inactivating …
JA Knight, C Smith, N Toohey, MT Klein, M Teitler
Molecular pharmacology 75 (2), 374-380, 2009
482009
Distribution of 5‐ht1E receptors in the mammalian brain and cerebral vasculature: an immunohistochemical and pharmacological study
MT Klein, M Teitler
British journal of pharmacology 166 (4), 1290-1302, 2012
462012
Targeting selective activation of M1 for the treatment of Alzheimer’s disease: further chemical optimization and pharmacological characterization of the M1 positive allosteric …
JC Tarr, ML Turlington, PR Reid, TJ Utley, DJ Sheffler, HP Cho, R Klar, ...
ACS Chemical Neuroscience 3 (11), 884-895, 2012
452012
Clozapine and other competitive antagonists reactivate risperidone-inactivated h5-HT7 receptors: radioligand binding and functional evidence for GPCR …
M Teitler, N Toohey, JA Knight, MT Klein, C Smith
Psychopharmacology 212, 687-697, 2010
392010
Approaches for probing allosteric interactions at 7 transmembrane spanning receptors
MT Klein, PN Vinson, CM Niswender
Progress in molecular biology and translational science 115, 1-59, 2013
272013
Risperidone-induced inactivation and clozapine-induced reactivation of rat cortical astrocyte 5-hydroxytryptamine7 receptors: evidence for in situ G protein-coupled receptor …
C Smith, N Toohey, JA Knight, MT Klein, M Teitler
Molecular Pharmacology 79 (2), 318-325, 2011
272011
Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships
MT Klein, M Dukat, RA Glennon, M Teitler
Journal of Pharmacology and Experimental Therapeutics 337 (3), 860-867, 2011
222011
Human 5-HT7 receptor-induced inactivation of forskolin-stimulated adenylate cyclase by risperidone, 9-OH-risperidone and other “inactivating antagonists”
N Toohey, MT Klein, J Knight, C Smith, M Teitler
Molecular pharmacology 76 (3), 552-559, 2009
222009
Guinea pig hippocampal 5‐HT1E receptors: a tool for selective drug development
MT Klein, M Teitler
Journal of neurochemistry 109 (1), 268-274, 2009
132009
Antagonist interaction with the human 5‐HT7 receptor mediates the rapid and potent inhibition of non‐G‐protein‐stimulated adenylate cyclase activity: a novel …
MT Klein, M Teitler
British journal of pharmacology 162 (8), 1843-1854, 2011
112011
Improving the quality of post-anesthesia care: An evidence based initiative to decrease the incidence of postoperative nausea and vomiting in the post-anesthesia care unit
CA Smith, RE Haas, JC Zepp, M Klein
Perioperative Care and Operating Room Management 4, 12-16, 2016
72016
Towards selective drug development for the human 5-HT1E receptor: a comparison of 5-HT1E and 5-HT1F receptor structure-affinity relationships
MT Klein, M Dukat, RA Glennon, M Teitler
Journal of Pharmacology and Experimental Therapeutics, 2011
22011
International Union of Basic and Clinical Pharmacology. XXX: Classification of receptors for 5-hydroxytryptamine; pharmacology and function
GJ Sanger, NM Barnes, GP Ahern, C Becamel, J Bockaert, M Camilleri, ...
Pharmacological Reviews, 2020
2020
Novel Positive Allosteric Modulators Bias Acetylcholine Signaling at Human M4 Muscarinic Receptors
MT Klein, G Digby, C Niswender, C Tarr, M Poslusney, B Melancon, ...
The FASEB Journal 27, 1171.4-1171.4, 2013
2013
Methylecgonidine: more than a crack cocaine biomarker
RCT Garcia, LMM Dati, LHL Torres, JL Costa, M Yonamine, JC Florio, ...
Abstracts, 2013
2013
The Pharmacology and Distribution of Serotonin 5-HT-1E Receptors in the Mammalian Brain & Drug Development for the Human 5-HT-1E Receptor
MT Klein
Albany Medical College, 2011
2011
Pharmacological analysis of the novel, rapid and potent inactivation of the human 5-HT7 receptor by risperidone, 9-OH-risperidone and other" inactivating antagonists"
JA Knight, C Smith, N Toohey, MT Klein, M Teitler
Molecular Pharmacology, 2008
2008
Guinea pig hippocampal 5‐HT1E receptors: a tool for selective drug development
MT Klein, C Smith, N Toohey, M Teitler
The FASEB Journal 22, 720.8-720.8, 2008
2008
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Articles 1–19