| Aptamer-based multiplexed proteomic technology for biomarker discovery L Gold, D Ayers, J Bertino, C Bock, A Bock, E Brody, J Carter, ... Nature Precedings, 1-1, 2010 | 1604 | 2010 |
| Enzymatic nucleic acids containing 5'-and/or 3'-cap structures J Matulic-Adamic, L Beigelman, A Karpeisky, T Jarvis, N Usman, ... US Patent 5,998,203, 1999 | 513 | 1999 |
| Nucleic acid ligands with protein-like side chains: modified aptamers and their use as diagnostic and therapeutic agents JC Rohloff, AD Gelinas, TC Jarvis, UA Ochsner, DJ Schneider, L Gold, ... Molecular Therapy-Nucleic Acids 3, 2014 | 501 | 2014 |
| Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets DR Davies, AD Gelinas, C Zhang, JC Rohloff, JD Carter, D O’Connell, ... Proceedings of the National Academy of Sciences 109 (49), 19971-19976, 2012 | 271 | 2012 |
| Nucleic acid molecules with novel chemical compositions capable of modulating gene expression J Thompson, L Beigelman, J McSwiggen, A Karpeisky, L Bellon, ... US Patent 6,673,611, 2004 | 202 | 2004 |
| Poliovirus RNA recombination: mechanistic studies in the absence of selection. TC Jarvis, K Kirkegaard The EMBO journal 11 (8), 3135-3145, 1992 | 183 | 1992 |
| Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor S Gupta, M Hirota, SM Waugh, I Murakami, T Suzuki, M Muraguchi, ... Journal of Biological Chemistry 289 (12), 8706-8719, 2014 | 158 | 2014 |
| “Macromolecular crowding”: thermodynamic consequences for protein-protein interactions within the T4 DNA replication complex. TC Jarvis, DM Ring, SS Daube, PH Von Hippel Journal of Biological Chemistry 265 (25), 15160-15167, 1990 | 151 | 1990 |
| Aptamers and the RNA world, past and present L Gold, N Janjic, T Jarvis, D Schneider, JJ Walker, SK Wilcox, D Zichi Cold Spring Harbor perspectives in biology 4 (3), a003582, 2012 | 147 | 2012 |
| Structural and Enzymatic Studies of the T4 DNA Replication System: I. Physical characterization of the polymerase accessory protein complex TC Jarvis, LS Paul, PH Von Hippel Journal of Biological Chemistry 264 (21), 12709-12716, 1989 | 120 | 1989 |
| Aminoacyl-tRNA synthetases: essential and still promising targets for new anti-infective agents UA Ochsner, X Sun, T Jarvis, I Critchley, N Janjic Expert opinion on investigational drugs 16 (5), 573-593, 2007 | 117 | 2007 |
| The polymerase in its labyrinth: mechanisms and implications of RNA recombination TC Jarvis, K Kirkegaard Trends in Genetics 7 (6), 186-191, 1991 | 116 | 1991 |
| Optimizing the cell efficacy of synthetic ribozymes: site selection and chemical modifications of ribozymes targeting the proto-oncogene c-myb TC Jarvis, FE Wincott, LJ Alby, JA McSwiggen, L Beigelman, J Gustofson, ... Journal of Biological Chemistry 271 (46), 29107-29112, 1996 | 111 | 1996 |
| Crystal structure of interleukin-6 in complex with a modified nucleic acid ligand AD Gelinas, DR Davies, TE Edwards, JC Rohloff, JD Carter, C Zhang, ... Journal of Biological Chemistry 289 (12), 8720-8734, 2014 | 110 | 2014 |
| Protein signature of lung cancer tissues MR Mehan, D Ayers, D Thirstrup, W Xiong, RM Ostroff, EN Brody, ... PloS one 7 (4), e35157, 2012 | 108 | 2012 |
| Structure of PolC reveals unique DNA binding and fidelity determinants RJ Evans, DR Davies, JM Bullard, J Christensen, LS Green, JW Guiles, ... Proceedings of the National Academy of Sciences 105 (52), 20695-20700, 2008 | 106 | 2008 |
| Structural and Enzymatic Studies of the T4 DNA Replication System: II. ATPase properties of the polymerase accessory protein complex TC Jarvis, LS Paul, JW Hockensmith, PH Von Hippel Journal of Biological Chemistry 264 (21), 12717-12729, 1989 | 104 | 1989 |
| Nuclease-resistant ribozymes decrease stromelysin mRNA levels in rabbit synovium following exogenous delivery to the knee joint. CM Flory, PA Pavco, TC Jarvis, ME Lesch, FE Wincott, L Beigelman, ... Proceedings of the National Academy of Sciences 93 (2), 754-758, 1996 | 95 | 1996 |
| Inhibition of vascular smooth muscle cell proliferation by ribozymes that cleave c-myb mRNA. TC Jarvis, LJ Alby, AA Beaudry, FE Wincott, L Beigelman, JA McSwiggen, ... Rna 2 (5), 419, 1996 | 94 | 1996 |
| Highly multiplexed proteomic platform for biomarker discovery, diagnostics, and therapeutics MR Mehan, R Ostroff, SK Wilcox, F Steele, D Schneider, TC Jarvis, ... Complement Therapeutics, 283-300, 2013 | 93 | 2013 |
