Tau protein liquid–liquid phase separation can initiate tau aggregation S Wegmann, B Eftekharzadeh, K Tepper, KM Zoltowska, RE Bennett, ... The EMBO journal 37 (7), e98049, 2018 | 798 | 2018 |
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain S Takeda, S Wegmann, H Cho, SL DeVos, C Commins, AD Roe, ... Nature communications 6 (1), 8490, 2015 | 348 | 2015 |
The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer’s disease SC Hopp, Y Lin, D Oakley, AD Roe, SL DeVos, D Hanlon, BT Hyman Journal of neuroinflammation 15, 1-15, 2018 | 241 | 2018 |
Enhanced tau aggregation in the presence of amyloid β RE Bennett, SL DeVos, S Dujardin, B Corjuc, R Gor, J Gonzalez, AD Roe, ... The American journal of pathology 187 (7), 1601-1612, 2017 | 217 | 2017 |
Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain E Hudry, J Dashkoff, AD Roe, S Takeda, RM Koffie, T Hashimoto, ... Science translational medicine 5 (212), 212ra161-212ra161, 2013 | 181 | 2013 |
Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity S Wegmann, EA Maury, MJ Kirk, L Saqran, A Roe, SL DeVos, S Nicholls, ... The EMBO journal 34 (24), 3028-3041, 2015 | 120 | 2015 |
Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly JP Chhatwal, AP Schultz, GA Marshall, B Boot, T Gomez-Isla, J Dumurgier, ... Neurology 87 (9), 920-926, 2016 | 117 | 2016 |
Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation RA Rissman, MA Staup, AR Lee, NJ Justice, KC Rice, W Vale, ... Proceedings of the National Academy of Sciences 109 (16), 6277-6282, 2012 | 113 | 2012 |
Seed‐competent high‐molecular‐weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients S Takeda, C Commins, SL DeVos, CK Nobuhara, S Wegmann, AD Roe, ... Annals of neurology 80 (3), 355-367, 2016 | 105 | 2016 |
Tau antibody targeting pathological species blocks neuronal uptake and interneuron propagation of tau in vitro CK Nobuhara, SL DeVos, C Commins, S Wegmann, BD Moore, AD Roe, ... The American journal of pathology 187 (6), 1399-1412, 2017 | 103 | 2017 |
Synaptic phosphorylated α-synuclein in dementia with Lewy bodies M Colom-Cadena, J Pegueroles, AG Herrmann, CM Henstridge, L Munoz, ... Brain 140 (12), 3204-3214, 2017 | 102 | 2017 |
Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo SL DeVos, BT Corjuc, C Commins, S Dujardin, RN Bannon, D Corjuc, ... Brain 141 (7), 2194-2212, 2018 | 94 | 2018 |
Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease S Takeda, T Hashimoto, AD Roe, Y Hori, TL Spires-Jones, BT Hyman The FASEB Journal 27 (8), 3239, 2013 | 73 | 2013 |
Reversal of neurofibrillary tangles and tau-associated phenotype in the rTgTauEC model of early Alzheimer's disease M Polydoro, A de Calignon, M Suárez-Calvet, L Sanchez, KR Kay, ... Journal of Neuroscience 33 (33), 13300-13311, 2013 | 60 | 2013 |
β-Amyloid induces pathology-related patterns of tau hyperphosphorylation at synaptic terminals HY Wu, PC Kuo, YT Wang, HT Lin, AD Roe, BY Wang, CL Han, ... Journal of Neuropathology & Experimental Neurology 77 (9), 814-826, 2018 | 56 | 2018 |
Increased tau phosphorylation and aggregation in the hippocampus of mice overexpressing corticotropin-releasing factor SN Campbell, C Zhang, L Monte, AD Roe, KC Rice, Y Taché, E Masliah, ... Journal of Alzheimer's Disease 43 (3), 967-976, 2015 | 53 | 2015 |
Lipopolysaccharide‐induced tau phosphorylation and kinase activity–modulation, but not mediation, by corticotropin‐releasing factor receptors AD Roe, MA Staup, J Serrats, PE Sawchenko, RA Rissman European Journal of Neuroscience 34 (3), 448-456, 2011 | 51 | 2011 |
Impact of CRFR1 ablation on amyloid-β production and accumulation in a mouse model of Alzheimer's disease SN Campbell, C Zhang, AD Roe, N Lee, KU Lao, L Monte, MC Donohue, ... Journal of Alzheimer's Disease 45 (4), 1175-1184, 2015 | 42 | 2015 |
Characterization of TauC3 antibody and demonstration of its potential to block tau propagation SB Nicholls, SL DeVos, C Commins, C Nobuhara, RE Bennett, DL Corjuc, ... PLoS One 12 (5), e0177914, 2017 | 40 | 2017 |
Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy TL Spires-Jones, T Friedman, R Pitstick, M Polydoro, A Roe, GA Carlson, ... Neuroscience letters 562, 63-68, 2014 | 39 | 2014 |