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Michael A. Lodato
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Histone H3K27ac separates active from poised enhancers and predicts developmental state
MP Creyghton, AW Cheng, GG Welstead, T Kooistra, BW Carey, ...
Proceedings of the National Academy of Sciences 107 (50), 21931-21936, 2010
42852010
A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types
M Wernig, CJ Lengner, J Hanna, MA Lodato, E Steine, R Foreman, ...
Nature biotechnology 26 (8), 916-924, 2008
5732008
Somatic mutation in single human neurons tracks developmental and transcriptional history
MA Lodato, MB Woodworth, S Lee, GD Evrony, BK Mehta, A Karger, ...
Science 350 (6256), 94-98, 2015
5712015
Aging and neurodegeneration are associated with increased mutations in single human neurons
MA Lodato, RE Rodin, CL Bohrson, ME Coulter, AR Barton, M Kwon, ...
Science 359 (6375), 555-559, 2018
5342018
H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment
MP Creyghton, S Markoulaki, SS Levine, J Hanna, MA Lodato, K Sha, ...
Cell 135 (4), 649-661, 2008
3882008
Functional integration of dopaminergic neurons directly converted from mouse fibroblasts
J Kim, SC Su, H Wang, AW Cheng, JP Cassady, MA Lodato, CJ Lengner, ...
Cell stem cell 9 (5), 413-419, 2011
3112011
Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network
MJ McConnell, JV Moran, A Abyzov, S Akbarian, T Bae, I Cortes-Ciriano, ...
Science 356 (6336), eaal1641, 2017
2442017
SOX2 co-occupies distal enhancer elements with distinct POU factors in ESCs and NPCs to specify cell state
MA Lodato, CW Ng, JA Wamstad, AW Cheng, KK Thai, E Fraenkel, ...
PLoS genetics 9 (2), e1003288, 2013
1962013
SapT, a lanthionine‐containing peptide involved in aerial hyphae formation in the streptomycetes
S Kodani, MA Lodato, MC Durrant, F Picart, JM Willey
Molecular microbiology 58 (5), 1368-1380, 2005
1352005
Somatic genomic changes in single Alzheimer’s disease neurons
MB Miller, AY Huang, J Kim, Z Zhou, SL Kirkham, EA Maury, ...
Nature 604 (7907), 714-722, 2022
1072022
Reprogramming of postnatal neurons into induced pluripotent stem cells by defined factors
J Kim, CJ Lengner, O Kirak, J Hanna, JP Cassady, MA Lodato, S Wu, ...
Stem cells 29 (6), 992-1000, 2011
952011
Linked-read analysis identifies mutations in single-cell DNA-sequencing data
CL Bohrson, AR Barton, MA Lodato, RE Rodin, LJ Luquette, ...
Nature genetics 51 (4), 749-754, 2019
842019
Genome aging: somatic mutation in the brain links age-related decline with disease and nominates pathogenic mechanisms
MA Lodato, CA Walsh
Human molecular genetics 28 (R2), R197-R206, 2019
472019
Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability
T Bae, L Fasching, Y Wang, JH Shin, M Suvakov, Y Jang, S Norton, ...
Science 377 (6605), 511-517, 2022
322022
Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements
LJ Luquette, MB Miller, Z Zhou, CL Bohrson, Y Zhao, H Jin, D Gulhan, ...
Nature genetics 54 (10), 1564-1571, 2022
302022
Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity
S Choudhury, AY Huang, J Kim, Z Zhou, K Morillo, EA Maury, JW Tsai, ...
Nature aging 2 (8), 714-725, 2022
262022
Persistent DNA damage associated with ATM kinase deficiency promotes microglial dysfunction
J Bourseguin, W Cheng, E Talbot, L Hardy, J Lai, AM Jeffries, MA Lodato, ...
Nucleic acids research 50 (5), 2700-2718, 2022
212022
APP gene copy number changes reflect exogenous contamination
J Kim, B Zhao, AY Huang, MB Miller, MA Lodato, CA Walsh, EA Lee
Nature 584 (7821), E20-E28, 2020
172020
Ultraspecific somatic SNV and indel detection in single neurons using primary template-directed amplification
LJ Luquette, MB Miller, Z Zhou, CL Bohrson, A Galor, MA Lodato, ...
BioRxiv, 2021.04. 30.442032, 2021
162021
PaSD-qc: quality control for single cell whole-genome sequencing data using power spectral density estimation
MA Sherman, AR Barton, MA Lodato, C Vitzthum, ME Coulter, CA Walsh, ...
Nucleic acids research 46 (4), e20-e20, 2018
142018
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