| Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration CA Saura, SY Choi, V Beglopoulos, S Malkani, D Zhang, BSS Rao, ... Neuron 42 (1), 23-36, 2004 | 885 | 2004 |
| The role of CREB signaling in Alzheimer’s disease and other cognitive disorders CA Saura, J Valero Walter de Gruyter 22 (2), 153-169, 2011 | 344 | 2011 |
| APP processing and synaptic plasticity in presenilin-1 conditional knockout mice H Yu, CA Saura, SY Choi, LD Sun, X Yang, M Handler, T Kawarabayashi, ... Neuron 31 (5), 713-726, 2001 | 308 | 2001 |
| Intraneuronal β-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice J España, L Giménez-Llort, J Valero, A Miñano, A Rábano, ... Biological psychiatry 67 (6), 513-521, 2010 | 212 | 2010 |
| Reduced β-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice V Beglopoulos, X Sun, CA Saura, CA Lemere, RD Kim, J Shen Journal of Biological Chemistry 279 (45), 46907-46914, 2004 | 192 | 2004 |
| Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein … CA Saura, G Chen, S Malkani, SY Choi, RH Takahashi, D Zhang, ... Journal of Neuroscience 25 (29), 6755-6764, 2005 | 183 | 2005 |
| Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells S Gines, E Ivanova, IS Seong, CA Saura, ME MacDonald Journal of Biological Chemistry 278 (50), 50514-50522, 2003 | 171 | 2003 |
| Long-term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activity A Giralt, M Puigdellívol, O Carretón, P Paoletti, J Valero, A Parra-Damas, ... Human molecular genetics 21 (6), 1203-1216, 2012 | 163 | 2012 |
| Short-Term Environmental Enrichment Rescues Adult Neurogenesis and Memory Deficits in APPSw,Ind Transgenic Mice J Valero, J Espana, A Parra-Damas, E Martin, J Rodriguez-Alvarez, ... PloS one 6 (2), e16832, 2011 | 136 | 2011 |
| β-Amyloid disrupts activity-dependent gene transcription required for memory through the CREB coactivator CRTC1 J España, J Valero, AJ Miñano-Molina, R Masgrau, E Martín, ... Journal of Neuroscience 30 (28), 9402-9410, 2010 | 134 | 2010 |
| Soluble oligomers of amyloid-β peptide disrupt membrane trafficking of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor contributing to early synapse dysfunction AJ Minano-Molina, J España, E Martín, B Barneda-Zahonero, R Fado, ... Journal of Biological Chemistry 286 (31), 27311-27321, 2011 | 124 | 2011 |
| Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB1 and CB2 receptors and relevance for Alzheimer’s disease and levodopa … G Navarro, D Borroto-Escuela, E Angelats, Í Etayo, I Reyes-Resina, ... Brain, behavior, and immunity 67, 139-151, 2018 | 122 | 2018 |
| Adenosine deaminase and A1 adenosine receptors internalize together following agonist-induced receptor desensitization CA Saura, J Mallol, EI Canela, C Lluis, R Franco Journal of Biological Chemistry 273 (28), 17610-17617, 1998 | 117 | 1998 |
| Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages A Parra-Damas, J Valero, M Chen, J Espana, E Martín, I Ferrer, ... Journal of Neuroscience 34 (17), 5776-5787, 2014 | 105 | 2014 |
| Altered microRNAs related to synaptic function as potential plasma biomarkers for Alzheimer’s disease D Siedlecki-Wullich, J Català-Solsona, C Fábregas, I Hernández, ... Alzheimer's research & therapy 11, 1-11, 2019 | 101 | 2019 |
| A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface JY Leem, CA Saura, C Pietrzik, J Christianson, C Wanamaker, LST King, ... Neurobiology of disease 11 (1), 64-82, 2002 | 97 | 2002 |
| Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing CA Saura, T Tomita, F Davenport, CL Harris, T Iwatsubo, G Thinakaran Journal of Biological Chemistry 274 (20), 13818-13823, 1999 | 96 | 1999 |
| Emerging roles of CREB-regulated transcription coactivators in brain physiology and pathology CA Saura, JR Cardinaux Trends in neurosciences 40 (12), 720-733, 2017 | 95 | 2017 |
| The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced Aβ42 production mediated by familial early onset Alzheimer's … CA Saura, T Tomita, S Soriano, M Takahashi, JY Leem, T Honda, EH Koo, ... Journal of Biological Chemistry 275 (22), 17136-17142, 2000 | 85 | 2000 |
| Functional implications of the presenilin dimerization: reconstitution of γ-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically … S Cervantes, CA Saura, E Pomares, R Gonzalez-Duarte, G Marfany Journal of Biological Chemistry 279 (35), 36519-36529, 2004 | 84 | 2004 |
