| The functions and regulation of the PTEN tumour suppressor: new modes and prospects YR Lee, M Chen, PP Pandolfi Nature reviews Molecular cell biology 19 (9), 547-562, 2018 | 693 | 2018 |
| An integrated genome-wide CRISPRa approach to functionalize lncRNAs in drug resistance AC Bester, JD Lee, A Chavez, YR Lee, D Nachmani, S Vora, J Victor, ... Cell 173 (3), 649-664. e20, 2018 | 286 | 2018 |
| An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer M Chen, J Zhang, K Sampieri, JG Clohessy, L Mendez, ... Nature genetics 50 (2), 206-218, 2018 | 267 | 2018 |
| K33-linked polyubiquitination of coronin 7 by Cul3-KLHL20 ubiquitin E3 ligase regulates protein trafficking WC Yuan, YR Lee, SY Lin, LY Chang, YP Tan, CC Hung, JC Kuo, CH Liu, ... Molecular cell 54 (4), 586-600, 2014 | 235 | 2014 |
| Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway YR Lee, M Chen, JD Lee, J Zhang, SY Lin, TM Fu, H Chen, T Ishikawa, ... Science 364 (6441), eaau0159, 2019 | 231 | 2019 |
| A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression WC Yuan, YR Lee, SF Huang, YM Lin, TY Chen, HC Chung, CH Tsai, ... Cancer cell 20 (2), 214-228, 2011 | 187 | 2011 |
| The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses YR Lee, WC Yuan, HC Ho, CH Chen, HM Shih, RH Chen The EMBO journal 29 (10), 1748-1761, 2010 | 128 | 2010 |
| The tumor suppressor DAPK is reciprocally regulated by tyrosine kinase Src and phosphatase LAR WJ Wang, JC Kuo, W Ku, YR Lee, FC Lin, YL Chang, YM Lin, CH Chen, ... Molecular cell 27 (5), 701-716, 2007 | 95 | 2007 |
| PTEN methylation by NSD2 controls cellular sensitivity to DNA damage J Zhang, YR Lee, F Dang, W Gan, AV Menon, JM Katon, CH Hsu, ... Cancer discovery 9 (9), 1306-1323, 2019 | 65 | 2019 |
| WWP1 gain-of-function inactivation of PTEN in cancer predisposition YR Lee, L Yehia, T Kishikawa, Y Ni, B Leach, J Zhang, N Panch, J Liu, ... New England Journal of Medicine 382 (22), 2103-2116, 2020 | 55 | 2020 |
| The functions and regulations of DAPK in cancer metastasis HY Chen, YR Lee, RH Chen Apoptosis 19, 364-370, 2014 | 49 | 2014 |
| The role of PML ubiquitination in human malignancies RH Chen, YR Lee, WC Yuan Journal of biomedical science 19, 1-7, 2012 | 45 | 2012 |
| Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1 T Zhang, D Xu, E Trefts, M Lv, H Inuzuka, G Song, M Liu, J Lu, J Liu, ... Science 380 (6652), 1372-1380, 2023 | 16 | 2023 |
| PTEN mouse models of cancer initiation and progression YR Lee, PP Pandolfi Cold Spring Harbor Perspectives in Medicine 10 (2), a037283, 2020 | 15 | 2020 |
| PTEN methylation by NSD2 controls cellular sensitivity to DNA damage. Cancer Discov. 2019; 9: 1306–1323. doi: 10.1158/2159-8290 J Zhang, YR Lee, F Dang, W Gan, AV Menon, JM Katon, CH Hsu, ... CD-18-0083.[Europe PMC free article][Abstract][CrossRef][Google Scholar], 0 | 9 | |
| WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models T Kishikawa, H Higuchi, L Wang, N Panch, V Maymi, S Best, S Lee, ... The Journal of Clinical Investigation 131 (24), 2021 | 8 | 2021 |
| Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation T Zhang, D Xu, J Liu, M Wang, LJ Duan, M Liu, H Meng, Y Zhuang, ... Nature cell biology 25 (7), 950-962, 2023 | 7 | 2023 |
| ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy X Xiao, J Shi, C He, X Bu, Y Sun, M Gao, B Xiang, W Xiong, P Dai, Q Mao, ... Nature Communications 14 (1), 2859, 2023 | 6 | 2023 |
| UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity C He, X Xing, HY Chen, M Gao, J Shi, B Xiang, X Xiao, Y Sun, H Yu, G Xu, ... Molecular Cell, 2024 | 2 | 2024 |
| Compositions and methods for treating cancer W Wei, PP Pandolfi, YR Lee US Patent App. 16/976,996, 2021 | | 2021 |
