| Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program D Taliun, DN Harris, MD Kessler, J Carlson, ZA Szpiech, R Torres, ... Nature 590 (7845), 290-299, 2021 | 1318 | 2021 |
| The vaso‐occlusive pain crisis in sickle cell disease: definition, pathophysiology, and management DS Darbari, VA Sheehan, SK Ballas European journal of haematology 105 (3), 237-246, 2020 | 142 | 2020 |
| Highly efficient editing of the β-globin gene in patient-derived hematopoietic stem and progenitor cells to treat sickle cell disease SH Park, CM Lee, DP Dever, TH Davis, J Camarena, W Srifa, Y Zhang, ... Nucleic acids research 47 (15), 7955-7972, 2019 | 141 | 2019 |
| Genetic modifiers of sickle cell anemia in the BABY HUG cohort: influence on laboratory and clinical phenotypes VA Sheehan, Z Luo, JM Flanagan, TA Howard, BW Thompson, WC Wang, ... American journal of hematology 88 (7), 571-576, 2013 | 96 | 2013 |
| Genetic mapping and exome sequencing identify 2 mutations associated with stroke protection in pediatric patients with sickle cell anemia JM Flanagan, V Sheehan, H Linder, TA Howard, YD Wang, CC Hoppe, ... Blood, The Journal of the American Society of Hematology 121 (16), 3237-3245, 2013 | 84 | 2013 |
| Fetal haemoglobin induction in sickle cell disease A Paikari, VA Sheehan British journal of haematology 180 (2), 189-200, 2018 | 76 | 2018 |
| End points for sickle cell disease clinical trials: patient-reported outcomes, pain, and the brain AT Farrell, J Panepinto, CP Carroll, DS Darbari, AA Desai, AA King, ... Blood Advances 3 (23), 3982-4001, 2019 | 59 | 2019 |
| Gene replacement of α-globin with β-globin restores hemoglobin balance in β-thalassemia-derived hematopoietic stem and progenitor cells MK Cromer, J Camarena, RM Martin, BJ Lesch, CA Vakulskas, NM Bode, ... Nature medicine 27 (4), 677-687, 2021 | 57 | 2021 |
| Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells Y Zhang, A Paikari, P Sumazin, CC Ginter Summarell, JR Crosby, ... Blood, The Journal of the American Society of Hematology 132 (3), 321-333, 2018 | 54 | 2018 |
| A novel high-throughput molecular counting method with single base-pair resolution enables accurate single-gene NIPT DS Tsao, S Silas, BP Landry, NP Itzep, AB Nguyen, S Greenberg, ... Scientific reports 9 (1), 14382, 2019 | 49 | 2019 |
| Whole exome sequencing identifies novel genes for fetal hemoglobin response to hydroxyurea in children with sickle cell anemia VA Sheehan, JR Crosby, A Sabo, NA Mortier, TA Howard, DM Muzny, ... PLoS One 9 (10), e110740, 2014 | 40 | 2014 |
| Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease JB Nielsen, O Rom, I Surakka, SE Graham, W Zhou, T Roychowdhury, ... Nature communications 11 (1), 6417, 2020 | 38 | 2020 |
| The role of BCL11A and HMIP-2 polymorphisms on endogenous and hydroxyurea induced levels of fetal hemoglobin in sickle cell anemia patients from southern Brazil JR Friedrisch, V Sheehan, JM Flanagan, A Baldan, CCG Summarell, ... Blood Cells, Molecules, and Diseases 62, 32-37, 2016 | 33 | 2016 |
| Comprehensive analysis and accurate quantification of unintended large gene modifications induced by CRISPR-Cas9 gene editing SH Park, M Cao, Y Pan, TH Davis, L Saxena, H Deshmukh, Y Fu, ... Science Advances 8 (42), eabo7676, 2022 | 28 | 2022 |
| Oxygen gradient ektacytometry‐derived biomarkers are associated with vaso‐occlusive crises and correlate with treatment response in sickle cell disease MAE Rab, CK Kanne, J Bos, BA van Oirschot, C Boisson, ME Houwing, ... American journal of hematology 96 (1), E29, 2021 | 26 | 2021 |
| p53 nongenotoxic activation and mTORC1 inhibition lead to effective combination for neuroblastoma therapy M Moreno-Smith, A Lakoma, Z Chen, L Tao, KA Scorsone, L Schild, ... Clinical Cancer Research 23 (21), 6629-6639, 2017 | 26 | 2017 |
| Genetic modifiers of severity in sickle cell disease AK Chang, CC Ginter Summarell, PT Birdie, VA Sheehan Clinical hemorheology and microcirculation 68 (2-3), 147-164, 2018 | 25 | 2018 |
| Inhibition of Listeria monocytogenes in Deli-Style Turkey Breast formulated with cultured celery powder and/or Cultured Sugar–Vinegar Blend during Storage at 4 C MC Golden, LM McDonnell, V Sheehan, JJ Sindelar, KA Glass Journal of Food Protection 77 (10), 1787-1793, 2014 | 24 | 2014 |
| Transcranial Doppler velocity and brain MRI/MRA changes in children with sickle cell anemia on chronic transfusions to prevent primary stroke VA Sheehan, EN Hansbury, MP Smeltzer, G Fortner, MB McCarville, ... Pediatric Blood & Cancer 60 (9), 1499-1502, 2013 | 22 | 2013 |
| Blood rheology biomarkers in sickle cell disease M Lu, MAE Rab, SS Shevkoplyas, VA Sheehan Experimental Biology and Medicine 245 (2), 155-165, 2020 | 21 | 2020 |
