| A proteome-wide atlas of lysine-reactive chemistry ME Abbasov, ME Kavanagh, TA Ichu, MR Lazear, Y Tao, VM Crowley, ... Nature chemistry 13 (11), 1081-1092, 2021 | 121 | 2021 |
| Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors ME Kavanagh, AG Coyne, KJ McLean, GG James, CW Levy, LB Marino, ... Journal of medicinal chemistry 59 (7), 3272-3302, 2016 | 55 | 2016 |
| Effect of DMSO on protein structure and interactions assessed by collision-induced dissociation and unfolding DSH Chan, ME Kavanagh, KJ McLean, AW Munro, D Matak-Vinković, ... Analytical chemistry 89 (18), 9976-9983, 2017 | 51 | 2017 |
| Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors J Brem, T Panduwawala, JU Hansen, J Hewitt, E Liepins, P Donets, ... Nature Chemistry 14 (1), 15-24, 2022 | 44 | 2022 |
| Synthesis of biologically active seven-membered-ring heterocycles TA Reekie, ME Kavanagh, M Longworth, M Kassiou Synthesis 45 (23), 3211-3227, 2013 | 40 | 2013 |
| Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine ME Kavanagh, BD Horning, R Khattri, N Roy, JP Lu, LR Whitby, E Ye, ... Nature Chemical Biology 18 (12), 1388-1398, 2022 | 39 | 2022 |
| Optimisation of LRRK2 inhibitors and assessment of functional efficacy in cell-based models of neuroinflammation L Munoz, ME Kavanagh, AF Phoa, B Heng, N Dzamko, EJ Chen, ... European Journal of Medicinal Chemistry 95, 29-34, 2015 | 35 | 2015 |
| The development of CNS-active LRRK2 inhibitors using property-directed optimisation ME Kavanagh, MR Doddareddy, M Kassiou Bioorganic & medicinal chemistry letters 23 (13), 3690-3696, 2013 | 34 | 2013 |
| Structural characterization and ligand/inhibitor identification provide functional insights into the Mycobacterium tuberculosis cytochrome P450 CYP126A1 JT Chenge, S Swami, KJ McLean, ME Kavanagh, AG Coyne, SEJ Rigby, ... Journal of Biological Chemistry 292 (4), 1310-1329, 2017 | 21 | 2017 |
| Spirooxindoles as novel 3D-fragment scaffolds: Synthesis and screening against CYP121 from M. tuberculosis HJ Davis, ME Kavanagh, T Balan, C Abell, AG Coyne Bioorganic & Medicinal Chemistry Letters 26 (15), 3735-3740, 2016 | 21 | 2016 |
| Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors ME Kavanagh, JL Gray, SH Gilbert, AG Coyne, KJ McLean, HJ Davis, ... ChemMedChem 11 (17), 1924-1935, 2016 | 19 | 2016 |
| Structural characterization of CYP144A1–a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis J Chenge, ME Kavanagh, MD Driscoll, KJ McLean, DB Young, T Cortes, ... Scientific reports 6 (1), 1-12, 2016 | 12 | 2016 |
| Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1 ME Kavanagh, J Chenge, A Zoufir, KJ McLean, AG Coyne, A Bender, ... Biochemistry 56 (11), 1559-1572, 2017 | 6 | 2017 |
| A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening … M Frederickson, IR Selvam, D Evangelopoulos, KJ McLean, MM Katariya, ... European journal of medicinal chemistry 230, 114105, 2022 | 5 | 2022 |
| Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis MM Katariya, M Snee, RB Tunnicliffe, ME Kavanagh, HIM Boshoff, ... Chemistry–A European Journal 29 (29), e202203868, 2023 | 2 | 2023 |
| Selective inhibitors of JAK1 targeting a subtype-restricted allosteric cysteine ME Kavanagh, BD Horning, R Khattri, N Roy, JP Lu, LR Whitby, ... bioRxiv, 2022.01. 31.478302, 2022 | | 2022 |
| Publisher Correction: A proteome-wide atlas of lysine-reactive chemistry ME Abbasov, ME Kavanagh, TA Ichu, MR Lazear, Y Tao, VM Crowley, ... Nature chemistry 13 (11), 1151, 2021 | | 2021 |
| Research data supporting" A fragment profiling approach to inhibitors of the orphan M. tuberculosis P450 CYP144A1" M Kavanagh, J Chenge, A Zoufir, KJ McLean, A Coyne, A Bender, ... | | 2017 |
| Corrigendum: Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors ME Kavanagh, JL Gray, SH Gilbert, AG Coyne, KJ McLean, HJ Davis, ... ChemMedChem 12 (2), 194, 2017 | | 2017 |
| Research data supporting" Spirooxindoles as novel 3D-fragment scaffolds: Synthesis and screening against CYP121 from M. tuberculosis" HJ Davis, ME Kavanagh, T Balan, C Abell, AG Coyne University of Cambridge, 2016 | | 2016 |
Andrew MunroProfessor of Molecular Enzymology, University of ManchesterVerified email at Manchester.ac.uk
