| RIP2 is a novel NF-κB-activating and cell death-inducing kinase JV McCarthy, J Ni, VM Dixit Journal of Biological Chemistry 273 (27), 16968-16975, 1998 | 570 | 1998 |
| Pathways of apoptosis and importance in developement C Twomey, JV McCarthy Journal of Cellular and Molecular Medicine 9 (2), 345-359, 2005 | 174 | 2005 |
| Cell shrinkage and apoptosis: a role for potassium and sodium ion efflux JV McCarthy, TG Cotter Cell Death & Differentiation 4 (8), 756-770, 1997 | 148 | 1997 |
| Presenilin-dependent regulated intramembrane proteolysis and γ-secretase activity JV McCarthy, C Twomey, P Wujek Cellular and molecular life sciences 66, 1534-1555, 2009 | 147 | 2009 |
| Apoptosis induced by Drosophila reaper and grim in a human system: attenuation by inhibitor of apoptosis proteins (cIAPs) JV McCarthy, VM Dixit Journal of Biological Chemistry 273 (37), 24009-24015, 1998 | 132 | 1998 |
| Glycogen synthase kinase-3β regulates presenilin 1 C-terminal fragment levels F Kirschenbaum, SC Hsu, B Cordell, JV McCarthy Journal of Biological Chemistry 276 (33), 30701-30707, 2001 | 129 | 2001 |
| Morphological assessment of apoptosis A Gorman Techniques in apoptosis, 1-20, 1996 | 127 | 1996 |
| Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathways SP Duggan, JV McCarthy Cellular signalling 28 (1), 1-11, 2016 | 120 | 2016 |
| Presenilin-1 is an unprimed glycogen synthase kinase-3β substrate C Twomey, JV McCarthy FEBS letters 580 (17), 4015-4020, 2006 | 99 | 2006 |
| Substitution of a glycogen synthase kinase-3β phosphorylation site in presenilin 1 separates presenilin function from β-catenin signaling F Kirschenbaum, SC Hsu, B Cordell, JV McCarthy Journal of Biological Chemistry 276 (10), 7366-7375, 2001 | 95 | 2001 |
| Interleukin-1 receptor type 1 is a substrate for γ-secretase-dependent regulated intramembrane proteolysis BM Elzinga, C Twomey, JC Powell, F Harte, JV McCarthy Journal of biological chemistry 284 (3), 1394-1409, 2009 | 67 | 2009 |
| The insulin-like growth factor 1 (IGF-1) receptor is a substrate for γ-secretase-mediated intramembrane proteolysis B McElroy, JC Powell, JV McCarthy Biochemical and biophysical research communications 358 (4), 1136-1141, 2007 | 63 | 2007 |
| Cell death in the myeloid lineage TG Cotter, RS Fernandes, S Verhaegln, JV McCarthy Immunological reviews 142 (1), 93-112, 1994 | 52 | 1994 |
| Regulated intramembrane proteolysis: emergent role in cell signalling pathways AJ McCarthy, C Coleman-Vaughan, JV McCarthy Biochemical Society Transactions 45 (6), 1185-1202, 2017 | 43 | 2017 |
| Association between Presenilin‐1 and TRAF6 modulates regulated intramembrane proteolysis of the p75NTR neurotrophin receptor JC Powell, C Twomey, R Jain, JV McCarthy Journal of neurochemistry 108 (1), 216-230, 2009 | 43 | 2009 |
| γ-Secretase activity is required for regulated intramembrane proteolysis of tumor necrosis factor (TNF) receptor 1 and TNF-mediated pro-apoptotic signaling J Chhibber-Goel, C Coleman-Vaughan, V Agrawal, N Sawhney, E Hickey, ... Journal of Biological Chemistry 291 (11), 5971-5985, 2016 | 37 | 2016 |
| Involvement of presenilins in cell-survival signalling pathways JV McCarthy Biochemical Society Transactions 33 (4), 568-572, 2005 | 36 | 2005 |
| TRAF6 promotes ubiquitination and regulated intramembrane proteolysis of IL-1R1 C Twomey, S Qian, JV McCarthy Biochemical and biophysical research communications 381 (3), 418-423, 2009 | 28 | 2009 |
| Apoptosis and development JV McCarthy Essays in biochemistry 39, 11-24, 2003 | 23 | 2003 |
| Gamma-secretase-independent role for cadherin-11 in neurotrophin receptor p75 (p75NTR) mediated glioblastoma cell migration J Berghoff, AV Jaisimha, S Duggan, J MacSharry, JV McCarthy Molecular and Cellular Neuroscience 69, 41-53, 2015 | 21 | 2015 |
Vishva Dixitvice-president, GenentechVerified email at gene.com
