Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells S Arora, J Heyza, H Zhang, V Kalman-Maltese, K Tillison, AM Floyd, ... Oncotarget 7 (46), 75104, 2016 | 59 | 2016 |
The USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancer lacking wild-type p53 C Hu, M Zhang, N Moses, C Hu, L Polin, W Chen, H Jang, J Heyza, ... Cell death & disease 11 (5), 328, 2020 | 44 | 2020 |
Gap junction intercellular communication positively regulates cisplatin toxicity by inducing DNA damage through bystander signaling S Arora, JR Heyza, EC Chalfin, RJ Ruch, SM Patrick Cancers 10 (10), 368, 2018 | 38 | 2018 |
Targeting the DNA repair endonuclease ERCC1-XPF with green tea polyphenol epigallocatechin-3-gallate (EGCG) and its prodrug to enhance cisplatin efficacy in human cancer cells JR Heyza, S Arora, H Zhang, KL Conner, W Lei, AM Floyd, RR Deshmukh, ... Nutrients 10 (11), 1644, 2018 | 36 | 2018 |
Identification and characterization of synthetic viability with ERCC1 deficiency in response to interstrand crosslinks in lung cancer JR Heyza, W Lei, D Watza, H Zhang, W Chen, JB Back, AG Schwartz, ... Clinical Cancer Research 25 (8), 2523-2536, 2019 | 25 | 2019 |
RHINO directs MMEJ to repair DNA breaks in mitosis A Brambati, O Sacco, S Porcella, J Heyza, M Kareh, JC Schmidt, A Sfeir Science 381 (6658), 653-660, 2023 | 17 | 2023 |
Nanoparticle-mediated gene silencing for sensitization of lung cancer to cisplatin therapy DP Feldmann, J Heyza, CM Zimmermann, SM Patrick, OM Merkel Molecules 25 (8), 1994, 2020 | 12 | 2020 |
Systematic analysis of the molecular and biophysical properties of key DNA damage response factors JR Heyza, M Mikhova, A Bahl, DG Broadbent, JC Schmidt Elife 12, e87086, 2023 | 10 | 2023 |
RHINO restricts MMEJ activity to mitosis A Brambati, O Sacco, S Porcella, J Heyza, M Kareh, JC Schmidt, A Sfeir Biorxiv, 2023.03. 16.532763, 2023 | 8 | 2023 |
In vivo targeting replication protein A for cancer therapy PS VanderVere-Carozza, NS Gavande, SI Jalal, KE Pollok, E Ekinci, ... Frontiers in Oncology 12, 826655, 2022 | 6 | 2022 |
Pathomimetic cancer avatars for live-cell imaging of protease activity K Ji, J Heyza, D Cavallo-Medved, BF Sloane Biochimie 122, 68-76, 2016 | 5 | 2016 |
Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells M Mikhova, JR Heyza, K Meek, JC Schmidt BioRxIV, 2023.06. 22.546088, 2023 | 4 | 2023 |
Chemical exhaustion of RPA in cancer treatment PS VanderVere-Carozza, KS Pawelczak, NS Gavande, SI Jalal, KE Pollok, ... BioRxIV, 2020.11. 30.404640, 2020 | 4 | 2020 |
Live cell single-molecule imaging to study DNA repair in human cells JR Heyza, M Mikhova, JC Schmidt DNA repair, 103540, 2023 | 2 | 2023 |
ATR inhibition overcomes platinum tolerance associated with ERCC1-and p53-deficiency by inducing replication catastrophe JR Heyza, E Ekinci, J Lindquist, W Lei, C Yunker, V Vinothkumar, ... NAR cancer 5 (1), zcac045, 2023 | 2 | 2023 |