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Joshua Heyza
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Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells
S Arora, J Heyza, H Zhang, V Kalman-Maltese, K Tillison, AM Floyd, ...
Oncotarget 7 (46), 75104, 2016
592016
The USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancer lacking wild-type p53
C Hu, M Zhang, N Moses, C Hu, L Polin, W Chen, H Jang, J Heyza, ...
Cell death & disease 11 (5), 328, 2020
442020
Gap junction intercellular communication positively regulates cisplatin toxicity by inducing DNA damage through bystander signaling
S Arora, JR Heyza, EC Chalfin, RJ Ruch, SM Patrick
Cancers 10 (10), 368, 2018
382018
Targeting the DNA repair endonuclease ERCC1-XPF with green tea polyphenol epigallocatechin-3-gallate (EGCG) and its prodrug to enhance cisplatin efficacy in human cancer cells
JR Heyza, S Arora, H Zhang, KL Conner, W Lei, AM Floyd, RR Deshmukh, ...
Nutrients 10 (11), 1644, 2018
362018
Identification and characterization of synthetic viability with ERCC1 deficiency in response to interstrand crosslinks in lung cancer
JR Heyza, W Lei, D Watza, H Zhang, W Chen, JB Back, AG Schwartz, ...
Clinical Cancer Research 25 (8), 2523-2536, 2019
252019
RHINO directs MMEJ to repair DNA breaks in mitosis
A Brambati, O Sacco, S Porcella, J Heyza, M Kareh, JC Schmidt, A Sfeir
Science 381 (6658), 653-660, 2023
172023
Nanoparticle-mediated gene silencing for sensitization of lung cancer to cisplatin therapy
DP Feldmann, J Heyza, CM Zimmermann, SM Patrick, OM Merkel
Molecules 25 (8), 1994, 2020
122020
Systematic analysis of the molecular and biophysical properties of key DNA damage response factors
JR Heyza, M Mikhova, A Bahl, DG Broadbent, JC Schmidt
Elife 12, e87086, 2023
102023
RHINO restricts MMEJ activity to mitosis
A Brambati, O Sacco, S Porcella, J Heyza, M Kareh, JC Schmidt, A Sfeir
Biorxiv, 2023.03. 16.532763, 2023
82023
In vivo targeting replication protein A for cancer therapy
PS VanderVere-Carozza, NS Gavande, SI Jalal, KE Pollok, E Ekinci, ...
Frontiers in Oncology 12, 826655, 2022
62022
Pathomimetic cancer avatars for live-cell imaging of protease activity
K Ji, J Heyza, D Cavallo-Medved, BF Sloane
Biochimie 122, 68-76, 2016
52016
Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells
M Mikhova, JR Heyza, K Meek, JC Schmidt
BioRxIV, 2023.06. 22.546088, 2023
42023
Chemical exhaustion of RPA in cancer treatment
PS VanderVere-Carozza, KS Pawelczak, NS Gavande, SI Jalal, KE Pollok, ...
BioRxIV, 2020.11. 30.404640, 2020
42020
Live cell single-molecule imaging to study DNA repair in human cells
JR Heyza, M Mikhova, JC Schmidt
DNA repair, 103540, 2023
22023
ATR inhibition overcomes platinum tolerance associated with ERCC1-and p53-deficiency by inducing replication catastrophe
JR Heyza, E Ekinci, J Lindquist, W Lei, C Yunker, V Vinothkumar, ...
NAR cancer 5 (1), zcac045, 2023
22023
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