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Sebastian Gergel
Sebastian Gergel
Lead Research Scientist at EnginZyme
Verified email at enginzyme.com
Title
Cited by
Cited by
Year
Asymmetric enzymatic hydration of unactivated, aliphatic alkenes
RM Demming, SC Hammer, BM Nestl, S Gergel, S Fademrecht, J Pleiss, ...
Angewandte Chemie 131 (1), 179-183, 2019
592019
Biocatalytic access to piperazines from diamines and dicarbonyls
N Borlinghaus, S Gergel, BM Nestl
ACS Catalysis 8 (4), 3727-3732, 2018
382018
Enzymatic control over reactive intermediates enables direct oxidation of alkenes to carbonyls by a P450 iron-oxo species
J Soler, S Gergel, C Klaus, SC Hammer, M Garcia-Borràs
Journal of the American Chemical Society 144 (35), 15954-15968, 2022
272022
Substrate Profiling of Anion Methyltransferases for Promiscuous Synthesis of S‐Adenosylmethionine Analogs from Haloalkanes
KH Schülke, F Ospina, K Hörnschemeyer, S Gergel, SC Hammer
ChemBioChem 23 (4), e202100632, 2022
222022
Engineered cytochrome P450 for direct arylalkene-to-ketone oxidation via highly reactive carbocation intermediates
S Gergel, J Soler, A Klein, KH Schülke, B Hauer, M Garcia-Borràs, ...
Nature Catalysis 6 (7), 606-617, 2023
112023
Methylation of Unactivated Alkenes with Engineered Methyltransferases To Generate Non‐natural Terpenoids
B Aberle, D Kowalczyk, S Massini, AN Egler‐Kemmerer, S Gergel, ...
Angewandte Chemie International Edition 62 (26), e202301601, 2023
72023
Directed evolution of a ketone synthase for efficient and highly selective functionalization of internal alkenes by accessing reactive carbocation intermediates
S Gergel, J Soler, A Klein, K Schülke, B Hauer, M Garcia-Borràs, ...
62022
Molecular Basis for Chemoselectivity Control in Oxidations of Internal Aryl-Alkenes Catalyzed by Laboratory Evolved P450s
J Soler, S Gergel, S Hammer, M Garcia-Borràs
2024
Methylierung nicht‐aktivierter Alkene mit modifizierten Methyltransferasen zur Diversifizierung von Terpenoiden
B Aberle, D Kowalczyk, S Massini, AN Egler‐Kemmerer, S Gergel, ...
Angewandte Chemie 135 (26), e202301601, 2023
2023
Gerichtete Evolution und mechanistische Studien von carbonylselektiven Alken-Oxygenasen und deren Anwendung in der asymmetrischen Synthese
S Gergel
Dissertation, Bielefeld, Universität Bielefeld, 2021, 2021
2021
3.5 Preparation of Imine Reductases at 15 L Scale and Their Application in Asymmetric Piperazine Synthesis
N Borlinghaus, S Gergel, BM Nestl, F Thol, H Penders
Applied Biocatalysis: The Chemist's Enzyme Toolbox, 156, 2020
2020
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