| Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial RE MacLaren, M Groppe, AR Barnard, CL Cottriall, T Tolmachova, ... The Lancet 383 (9923), 1129-1137, 2014 | 877 | 2014 |
| Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo H Maeda, LW Seymour, Y Miyamoto Bioconjugate chemistry 3 (5), 351-362, 1992 | 747 | 1992 |
| Effect of molecular weight (Mw) of N‐(2‐hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal … LW Seymour, R Duncan, J Strohalm, J Kopeček Journal of biomedical materials research 21 (11), 1341-1358, 1987 | 528 | 1987 |
| Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier LW Seymour, Y Miyamoto, H Maeda, M Brereton, J Strohalm, K Ulbrich, ... European Journal of Cancer 31 (5), 766-770, 1995 | 449 | 1995 |
| Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies KD Fisher, Y Stallwood, NK Green, K Ulbrich, V Mautner, LW Seymour Gene therapy 8 (5), 341-348, 2001 | 393 | 2001 |
| Extended plasma circulation time and decreased toxicity of polymer-coated adenovirus NK Green, CW Herbert, SJ Hale, AB Hale, V Mautner, R Harkins, ... Gene therapy 11 (16), 1256-1263, 2004 | 251 | 2004 |
| Preclinical evaluation of polymer-bound doxorubicin R Duncan, LW Seymour, KB O'Hare, PA Flanagan, S Wedge, IC Hume, ... Journal of controlled release 19 (1-3), 331-346, 1992 | 222 | 1992 |
| Directed evolution generates a novel oncolytic virus for the treatment of colon cancer I Kuhn, P Harden, M Bauzon, C Chartier, J Nye, S Thorne, T Reid, S Ni, ... PloS one 3 (6), e2409, 2008 | 220 | 2008 |
| Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1 A Benlahrech, J Harris, A Meiser, T Papagatsias, J Hornig, P Hayes, ... Proceedings of the National Academy of Sciences 106 (47), 19940-19945, 2009 | 194 | 2009 |
| Pre-clinical and clinical study of QC12, a water-soluble, pro-drug of quercetin PJ Mulholland, DR Ferry, D Anderson, SA Hussain, AM Young, JE Cook, ... Annals of Oncology 12 (2), 245-248, 2001 | 182 | 2001 |
| The pharmacokinetics of polymer-bound adriamycin LW Seymour, K Ulbrich, J Strohalm, J Kopeček, R Duncan Biochemical pharmacology 39 (6), 1125-1131, 1990 | 156 | 1990 |
| Ultrasound-enhanced drug delivery for cancer S Mo, CC Coussios, L Seymour, R Carlisle Expert opinion on drug delivery 9 (12), 1525-1538, 2012 | 155 | 2012 |
| Phase 1 study of intravenous administration of the chimeric adenovirus enadenotucirev in patients undergoing primary tumor resection R Garcia-Carbonero, R Salazar, I Duran, I Osman-Garcia, L Paz-Ares, ... Journal for immunotherapy of cancer 5, 1-13, 2017 | 153 | 2017 |
| A versatile system for receptor-mediated gene delivery permits increased entry of DNA into target cells, enhanced delivery to the nucleus and elevated rates of transgene expression KD Fisher, K Ulbrich, V Subr, CM Ward, V Mautner, D Blakey, ... Gene therapy 7 (15), 1337-1343, 2000 | 143 | 2000 |
| N-(2-hydroxypropyl) methacrylamide copolymers targeted to the hepatocyte galactose-receptor: pharmacokinetics in DBA2 mice LW Seymour, K Ulbrich, SR Wedge, IC Hume, J Strohalm, R Duncan British journal of cancer 63 (6), 859-866, 1991 | 140 | 1991 |
| Inertial cavitation to non-invasively trigger and monitor intratumoral release of drug from intravenously delivered liposomes SM Graham, R Carlisle, JJ Choi, M Stevenson, AR Shah, RS Myers, ... Journal of Controlled Release 178, 101-107, 2014 | 106 | 2014 |
| Selective permeabilization of the blood–brain barrier at sites of metastasis JJ Connell, G Chatain, B Cornelissen, KA Vallis, A Hamilton, L Seymour, ... Journal of the national cancer institute 105 (21), 1634-1643, 2013 | 100 | 2013 |
| Deregulation of HLA-I in cancer and its central importance for immunotherapy A Hazini, K Fisher, L Seymour Journal for ImmunoTherapy of Cancer 9 (8), 2021 | 99 | 2021 |
| Non-invasive and real-time passive acoustic mapping of ultrasound-mediated drug delivery JJ Choi, RC Carlisle, C Coviello, L Seymour, CC Coussios Physics in Medicine & Biology 59 (17), 4861, 2014 | 98 | 2014 |
| Fluorescence studies of the intra-cellular distribution of zinc bis (thiosemicarbazone) complexes in human cancer cells AR Cowley, J Davis, JR Dilworth, PS Donnelly, R Dobson, A Nightingale, ... Chemical communications, 845-847, 2005 | 85 | 2005 |
