| Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery GM Popowicz, A Czarna, S Wolf, K Wang, W Wang, A Dömling, TA Holak Cell cycle 9 (6), 1104-1111, 2010 | 285 | 2010 |
| Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain G Popowicz, A Czarna, T Holak Cell cycle 7 (15), 2441-2443, 2008 | 229 | 2008 |
| Structures of Drosophila cryptochrome and mouse cryptochrome1 provide insight into circadian function A Czarna, A Berndt, HR Singh, A Grudziecki, AG Ladurner, G Timinszky, ... Cell 153 (6), 1394-1405, 2013 | 212 | 2013 |
| Molecular basis for the inhibition of p53 by Mdmx GM Popowicz, A Czarna, U Rothweiler, A Szwagierczak, M Krajewski, ... Cell cycle 6 (19), 2386-2392, 2007 | 176 | 2007 |
| Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: p53-Hdm2 antagonists A Czarna, B Beck, S Srivastava, G Popowicz, S Wolf, Y Huang, M Bista, ... Angewandte Chemie (International ed. in English) 49 (31), 5352, 2010 | 162 | 2010 |
| Rational designs of in vivo CRISPR-Cas delivery systems CF Xu, GJ Chen, YL Luo, Y Zhang, G Zhao, ZD Lu, A Czarna, Z Gu, ... Advanced drug delivery reviews 168, 3-29, 2021 | 147 | 2021 |
| High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx A Czarna, GM Popowicz, A Pecak, S Wolf, G Dubin, TA Holak Cell cycle 8 (8), 1176-1184, 2009 | 125 | 2009 |
| c-Kit–positive cardiac stem cells nested in hypoxic niches are activated by stem cell factor reversing the aging myopathy F Sanada, J Kim, A Czarna, NYK Chan, S Signore, B Ogórek, K Isobe, ... Circulation research 114 (1), 41-55, 2014 | 110 | 2014 |
| Isoquinolin‐1‐one Inhibitors of the MDM2–p53 Interaction U Rothweiler, A Czarna, M Krajewski, J Ciombor, C Kalinski, V Khazak, ... ChemMedChem: Chemistry Enabling Drug Discovery 3 (7), 1118-1128, 2008 | 91 | 2008 |
| Functional and structural characterization of Spl proteases from Staphylococcus aureus GM Popowicz, G Dubin, J Stec-Niemczyk, A Czarna, A Dubin, J Potempa, ... Journal of molecular biology 358 (1), 270-279, 2006 | 80 | 2006 |
| Enzymatic activity of the Staphylococcus aureus SplB serine protease is induced by substrates containing the sequence Trp-Glu-Leu-Gln G Dubin, J Stec-Niemczyk, M Kisielewska, K Pustelny, GM Popowicz, ... Journal of molecular biology 379 (2), 343-356, 2008 | 56 | 2008 |
| Quantitative analyses of cryptochrome-mBMAL1 interactions: mechanistic insights into the transcriptional regulation of the mammalian circadian clock A Czarna, H Breitkreuz, CC Mahrenholz, J Arens, HM Strauss, E Wolf Journal of Biological Chemistry 286 (25), 22414-22425, 2011 | 53 | 2011 |
| Rapid and efficient hydrophilicity tuning of p53/mdm2 antagonists S Srivastava, B Beck, W Wang, A Czarna, TA Holak, A Dömling Journal of combinatorial chemistry 11 (4), 631-639, 2009 | 40 | 2009 |
| Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses V Napolitano, A Dabrowska, K Schorpp, A Mourão, E Barreto-Duran, ... Cell Chemical Biology 29 (5), 774-784. e8, 2022 | 37 | 2022 |
| Novel scaffolds for Dual specificity tyrosine-phosphorylation-regulated kinase (DYRK1A) inhibitors A Czarna, J Wang, D Zelencova, Y Liu, X Deng, HG Choi, T Zhang, ... Journal of medicinal chemistry 61 (17), 7560-7572, 2018 | 32 | 2018 |
| An all-in-one nanomedicine consisting of CRISPR-Cas9 and an autoantigen peptide for restoring specific immune tolerance YL Luo, LF Liang, YJ Gan, J Liu, Y Zhang, YN Fan, G Zhao, A Czarna, ... ACS Applied Materials & Interfaces 12 (43), 48259-48271, 2020 | 26 | 2020 |
| Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity A Czarna, J Plewka, L Kresik, A Matsuda, A Karim, C Robinson, ... Structure 30 (8), 1050-1054. e2, 2022 | 23 | 2022 |
| Staphylococcal SplB serine protease utilizes a novel molecular mechanism of activation K Pustelny, M Zdzalik, N Stach, J Stec-Niemczyk, P Cichon, A Czarna, ... Journal of Biological Chemistry 289 (22), 15544-15553, 2014 | 19 | 2014 |
| NMR screening for lead compounds using tryptophan-mutated proteins U Rothweiler, A Czarna, L Weber, GM Popowicz, K Brongel, K Kowalska, ... Journal of medicinal chemistry 51 (16), 5035-5042, 2008 | 18 | 2008 |
| Single-cell analysis of the fate of c-kit-positive bone marrow cells A Czarna, F Sanada, A Matsuda, J Kim, S Signore, JD Pereira, ... NPJ Regenerative medicine 2 (1), 27, 2017 | 17 | 2017 |
