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Timothy Jacobsen
Timothy Jacobsen
Verified email at mssm.edu
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Developments in intervertebral disc disease research: pathophysiology, mechanobiology, and therapeutics
KT Weber, TD Jacobsen, R Maidhof, J Virojanapa, C Overby, O Bloom, ...
Current reviews in musculoskeletal medicine 8, 18-31, 2015
1022015
Inflammation induces irreversible biophysical changes in isolated nucleus pulposus cells
R Maidhof, T Jacobsen, A Papatheodorou, NO Chahine
PloS one 9 (6), e99621, 2014
622014
High mobility group box‐1 induces pro‐inflammatory signaling in human nucleus pulposus cells via toll‐like receptor 4‐dependent pathway
BS Shah, KG Burt, T Jacobsen, TD Fernandes, DO Alipui, KT Weber, ...
Journal of Orthopaedic Research® 37 (1), 220-231, 2019
492019
Effects of inflammation on multiscale biomechanical properties of cartilaginous cells and tissues
QT Nguyen, TD Jacobsen, NO Chahine
ACS Biomaterials Science & Engineering 3 (11), 2644-2656, 2017
392017
Timing of mesenchymal stem cell delivery impacts the fate and therapeutic potential in intervertebral disc repair
R Maidhof, A Rafiuddin, F Chowdhury, T Jacobsen, NO Chahine
Journal of Orthopaedic Research 35 (1), 32-40, 2017
352017
Actomyosin contractility confers mechanoprotection against TNFα-induced disruption of the intervertebral disc
PA Hernandez, TD Jacobsen, NO Chahine
Science advances 6 (34), eaba2368, 2020
232020
Three-dimensional-printed flexible scaffolds have tunable biomimetic mechanical properties for intervertebral disc tissue engineering
SL Marshall, TD Jacobsen, E Emsbo, A Murali, K Anton, JZ Liu, HH Lu, ...
ACS biomaterials science & engineering 7 (12), 5836-5849, 2021
202021
Avidin grafted dextran nanostructure enables a month-long intra-discal retention
EK Wagner, A Vedadghavami, TD Jacobsen, SA Goel, NO Chahine, ...
Scientific reports 10 (1), 12017, 2020
192020
Inhibition of toll-like receptor 4 protects against inflammation-induced mechanobiological alterations to intervertebral disc cells
TD Jacobsen, PA Hernandez, NO Chahine
European cells & materials 41, 576, 2021
92021
Confocal scanning of intervertebral disc cells in 3D: Inside alginate beads and in native microenvironment
PA Hernandez, TD Jacobsen, Z Barati, NO Chahine
Jor Spine 3 (4), e1106, 2020
72020
Toward defining the role of the synovium in mitigating normal articular cartilage wear and tear
MJ Pellicore, LR Gangi, LA Murphy, AJ Lee, T Jacobsen, HM Kenawy, ...
Journal of biomechanics 148, 111472, 2023
42023
Transient neonatal shoulder paralysis causes early osteoarthritis in a mouse model
LA Forrester, F Fang, T Jacobsen, Y Hu, I Kurtaliaj, BD Roye, ...
Journal of Orthopaedic Research® 40 (9), 1981-1992, 2022
22022
Anti-inflammatory agents prevent intervertebral disc cell mechanobiological alterations
T Jacobsen, N Chahine
Global Spine Journal 6 (1_suppl), s-0036-1582599-s-0036-1582599, 2016
22016
Relationship Between Inflammatory Stimulation and Cell Biomechanics in Intervertebral Disc Degeneration
TD Jacobsen
Columbia University, 2022
12022
P8. Responsiveness of patient derived intervertebral disc cells to mechanobiological treatment
N Chahine, T Jacobsen, E Leung, RA Lehman
The Spine Journal 22 (9), S129, 2022
2022
88. Cell stiffness decreases with severity of disc degeneration and inflammatory stimulation
N Chahine, E Leung, M Cerpa, M Vulapalli, V Boddapati, T Jacobsen, ...
The Spine Journal 20 (9), S43, 2020
2020
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