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"Small Molecule Discovery Center"
"Small Molecule Discovery Center"
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Title
Cited by
Cited by
Year
Drug discovery and development for neglected parasitic diseases
AR Renslo, JH McKerrow
Nature chemical biology 2 (12), 701-710, 2006
4142006
A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target
A Debnath, D Parsonage, RM Andrade, C He, ER Cobo, K Hirata, S Chen, ...
Nature medicine 18 (6), 956-960, 2012
3322012
Importazole, a small molecule inhibitor of the transport receptor importin-β
JF Soderholm, SL Bird, P Kalab, Y Sampathkumar, K Hasegawa, ...
ACS chemical biology 6 (7), 700-708, 2011
2762011
Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening
MH Abdulla, DS Ruelas, B Wolff, J Snedecor, KC Lim, F Xu, AR Renslo, ...
PLoS neglected tropical diseases 3 (7), e478, 2009
2352009
A Screen against Leishmania Intracellular Amastigotes: Comparison to a Promastigote Screen and Identification of a Host Cell-Specific Hit
G De Muylder, KKH Ang, S Chen, MR Arkin, JC Engel, JH McKerrow
PLoS neglected tropical diseases 5 (7), e1253, 2011
2252011
Screening for noise in gene expression identifies drug synergies
RD Dar, NN Hosmane, MR Arkin, RF Siliciano, LS Weinberger
Science 344 (6190), 1392-1396, 2014
2102014
Small-molecule activators of a proenzyme
DW Wolan, JA Zorn, DC Gray, JA Wells
Science 326 (5954), 853-858, 2009
1742009
Profiling of a prescription drug library for potential renal drug–drug interactions mediated by the organic cation transporter 2
Y Kido, P Matsson, KM Giacomini
Journal of medicinal chemistry 54 (13), 4548-4558, 2011
1732011
Discovery of 2-aminothiazoles as potent antiprion compounds
S Ghaemmaghami, BCH May, AR Renslo, SB Prusiner
Journal of virology 84 (7), 3408-3412, 2010
1692010
Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch
CM Gallagher, C Garri, EL Cain, KKH Ang, CG Wilson, S Chen, BR Hearn, ...
elife 5, e11878, 2016
1682016
Identification and optimization of inhibitors of trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB
BT Mott, RS Ferreira, A Simeonov, A Jadhav, KKH Ang, W Leister, M Shen, ...
Journal of medicinal chemistry 53 (1), 52-60, 2010
1652010
Turning a protein kinase on or off from a single allosteric site via disulfide trapping
JD Sadowsky, MA Burlingame, DW Wolan, CL McClendon, MP Jacobson, ...
Proceedings of the National Academy of Sciences 108 (15), 6056-6061, 2011
1612011
Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy
K Brak, ID Kerr, KT Barrett, N Fuchi, M Debnath, K Ang, JC Engel, ...
Journal of medicinal chemistry 53 (4), 1763-1773, 2010
1602010
2-Aminothiazoles as therapeutic leads for prion diseases
A Gallardo-Godoy, J Gever, KL Fife, BM Silber, SB Prusiner, AR Renslo
Journal of medicinal chemistry 54 (4), 1010-1021, 2011
1572011
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling
MB Wittwer, AA Zur, N Khuri, Y Kido, A Kosaka, X Zhang, KM Morrissey, ...
Journal of medicinal chemistry 56 (3), 781-795, 2013
1512013
Image-Based High-Throughput Drug Screening Targeting the Intracellular Stage of Trypanosoma cruzi, the Agent of Chagas' Disease
JC Engel, KKH Ang, S Chen, MR Arkin, JH McKerrow, PS Doyle
Antimicrobial agents and chemotherapy 54 (8), 3326-3334, 2010
1292010
Predicting and improving the membrane permeability of peptidic small molecules
SB Rafi, BR Hearn, P Vedantham, MP Jacobson, AR Renslo
Journal of medicinal chemistry 55 (7), 3163-3169, 2012
1222012
Predicting binding to p-glycoprotein by flexible receptor docking
E Dolghih, C Bryant, AR Renslo, MP Jacobson
PLoS computational biology 7 (6), e1002083, 2011
1182011
A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K2P Channels
SN Bagriantsev, KH Ang, A Gallardo-Godoy, KA Clark, MR Arkin, ...
ACS chemical biology 8 (8), 1841-1851, 2013
1122013
Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis
CA Bulman, CM Bidlow, S Lustigman, F Cho-Ngwa, D Williams, ...
PLoS neglected tropical diseases 9 (2), e0003534, 2015
1032015
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