| Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex MC Franklin, KD Carey, FF Vajdos, DJ Leahy, AM De Vos, MX Sliwkowski Cancer cell 5 (4), 317-328, 2004 | 1402 | 2004 |
| Structures of human acetylcholinesterase in complex with pharmacologically important ligands J Cheung, MJ Rudolph, F Burshteyn, MS Cassidy, EN Gary, J Love, ... Journal of medicinal chemistry 55 (22), 10282-10286, 2012 | 1101 | 2012 |
| Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail J Hansen, A Baum, KE Pascal, V Russo, S Giordano, E Wloga, BO Fulton, ... Science 369 (6506), 1010-1014, 2020 | 976 | 2020 |
| Structure of the replicating complex of a pol α family DNA polymerase MC Franklin, J Wang, TA Steitz Cell 105 (5), 657-667, 2001 | 664 | 2001 |
| Crystal structures of the HslVU peptidase–ATPase complex reveal an ATP-dependent proteolysis mechanism J Wang, JJ Song, MC Franklin, S Kamtekar, YJ Im, SH Rho, IS Seong, ... Structure 9 (2), 177-184, 2001 | 293 | 2001 |
| Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152) JA Flygare, M Beresini, N Budha, H Chan, IT Chan, S Cheeti, F Cohen, ... Journal of medicinal chemistry 55 (9), 4101-4113, 2012 | 266 | 2012 |
| Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP D Vucic, MC Franklin, HJA Wallweber, K Das, BP Eckelman, H Shin, ... Biochemical Journal 385 (1), 11-20, 2004 | 249 | 2004 |
| Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs K Zobel, L Wang, E Varfolomeev, MC Franklin, LO Elliott, HJA Wallweber, ... ACS chemical biology 1 (8), 525-533, 2006 | 241 | 2006 |
| Nucleotide-dependent conformational changes in a protease-associated ATPase HslU J Wang, JJ Song, IS Seong, MC Franklin, S Kamtekar, SH Eom, ... Structure 9 (11), 1107-1116, 2001 | 201 | 2001 |
| Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement JM Orengo, AR Radin, V Kamat, A Badithe, LH Ben, BL Bennett, S Zhong, ... Nature communications 9 (1), 1421, 2018 | 200 | 2018 |
| Monoclonal antibody cetuximab binds to and down-regulates constitutively activated epidermal growth factor receptor vIII on the cell surface D Patel, A Lahiji, S Patel, M Franklin, X Jimenez, DJ Hicklin, X Kang Anticancer research 27 (5A), 3355-3366, 2007 | 192 | 2007 |
| The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies R Copin, A Baum, E Wloga, KE Pascal, S Giordano, BO Fulton, A Zhou, ... Cell 184 (15), 3949-3961. e11, 2021 | 188 | 2021 |
| Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP) MC Franklin, S Kadkhodayan, H Ackerly, D Alexandru, MD Distefano, ... Biochemistry 42 (27), 8223-8231, 2003 | 134 | 2003 |
| Structural insights into mis-regulation of protein kinase A in human tumors J Cheung, C Ginter, M Cassidy, MC Franklin, MJ Rudolph, N Robine, ... Proceedings of the National Academy of Sciences 112 (5), 1374-1379, 2015 | 103 | 2015 |
| A conserved Tyr residue is required for sugar selectivity in a Pol α DNA polymerase G Yang, M Franklin, J Li, TC Lin, W Konigsberg Biochemistry 41 (32), 10256-10261, 2002 | 101 | 2002 |
| Structural genomics for drug design against the pathogen Coxiella burnetii MC Franklin, J Cheung, MJ Rudolph, F Burshteyn, M Cassidy, E Gary, ... Proteins: Structure, Function, and Bioinformatics 83 (12), 2124-2136, 2015 | 88 | 2015 |
| Structures of paraoxon‐inhibited human acetylcholinesterase reveal perturbations of the acyl loop and the dimer interface MC Franklin, MJ Rudolph, C Ginter, MS Cassidy, J Cheung Proteins: Structure, Function, and Bioinformatics 84 (9), 1246-1256, 2016 | 79 | 2016 |
| Orally Bioavailable Antagonists of Inhibitor of Apoptosis Proteins Based on an Azabicyclooctane Scaffold∞ F Cohen, B Alicke, LO Elliott, JA Flygare, T Goncharov, SF Keteltas, ... Journal of medicinal chemistry 52 (6), 1723-1730, 2009 | 76 | 2009 |
| Correlation of the kinetics of finger domain mutants in RB69 DNA polymerase with its structure G Yang, M Franklin, J Li, TC Lin, W Konigsberg Biochemistry 41 (8), 2526-2534, 2002 | 63 | 2002 |
| The structural basis for the function of two anti-VEGF receptor 2 antibodies MC Franklin, EC Navarro, Y Wang, S Patel, P Singh, Y Zhang, K Persaud, ... Structure 19 (8), 1097-1107, 2011 | 54 | 2011 |
John A FlygareMerckVerified email at merck.com
