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Andrew Kung
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Selective inhibition of BET bromodomains
P Filippakopoulos, J Qi, S Picaud, Y Shen, WB Smith, O Fedorov, ...
Nature 468 (7327), 1067-1073, 2010
42172010
BET bromodomain inhibition as a therapeutic strategy to target c-Myc
JE Delmore, GC Issa, ME Lemieux, PB Rahl, J Shi, HM Jacobs, E Kastritis, ...
Cell 146 (6), 904-917, 2011
30842011
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
E Weisberg, PW Manley, W Breitenstein, J Brüggen, SW Cowan-Jacob, ...
Cancer cell 7 (2), 129-141, 2005
19232005
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix
LD Walensky, AL Kung, I Escher, TJ Malia, S Barbuto, RD Wright, ...
science 305 (5689), 1466-1470, 2004
16652004
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing
C Kanellopoulou, SA Muljo, AL Kung, S Ganesan, R Drapkin, T Jenuwein, ...
Genes & development 19 (4), 489-501, 2005
15972005
Role of T-bet in commitment of TH1 cells before IL-12-dependent selection
AC Mullen, FA High, AS Hutchins, HW Lee, AV Villarino, DM Livingston, ...
Science 292 (5523), 1907-1910, 2001
11672001
Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor
SR Daigle, EJ Olhava, CA Therkelsen, CR Majer, CJ Sneeringer, J Song, ...
Cancer cell 20 (1), 53-65, 2011
10012011
MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L
KM Bernt, N Zhu, AU Sinha, S Vempati, J Faber, AV Krivtsov, Z Feng, ...
Cancer cell 20 (1), 66-78, 2011
9442011
Direct inhibition of the NOTCH transcription factor complex
RE Moellering, M Cornejo, TN Davis, CD Bianco, JC Aster, SC Blacklow, ...
Nature 462 (7270), 182-188, 2009
9202009
Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF
R Haq, J Shoag, P Andreu-Perez, S Yokoyama, H Edelman, GC Rowe, ...
Cancer cell 23 (3), 302-315, 2013
8392013
Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma
B Chapuy, MR McKeown, CY Lin, S Monti, MGM Roemer, J Qi, PB Rahl, ...
Cancer cell 24 (6), 777-790, 2013
8142013
Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors
CS Mitsiades, NS Mitsiades, CJ McMullan, V Poulaki, R Shringarpure, ...
Cancer cell 5 (3), 221-230, 2004
7922004
A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors
JB Rubin, AL Kung, RS Klein, JA Chan, YP Sun, K Schmidt, MW Kieran, ...
Proceedings of the National Academy of Sciences 100 (23), 13513-13518, 2003
7352003
Targeting MYCN in neuroblastoma by BET bromodomain inhibition
A Puissant, SM Frumm, G Alexe, CF Bassil, J Qi, YH Chanthery, ...
Cancer discovery 3 (3), 308-323, 2013
7002013
SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
H Inuzuka, S Shaik, I Onoyama, D Gao, A Tseng, RS Maser, B Zhai, ...
Nature 471 (7336), 104-109, 2011
6902011
Suppression of tumor growth through disruption of hypoxia-inducible transcription
AL Kung, S Wang, JM Klco, WG Kaelin, DM Livingston
Nature medicine 6 (12), 1335-1340, 2000
6902000
Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma
L Santo, T Hideshima, AL Kung, JC Tseng, D Tamang, M Yang, M Jarpe, ...
Blood, The Journal of the American Society of Hematology 119 (11), 2579-2589, 2012
6562012
Polyubiquitination of p53 by a ubiquitin ligase activity of p300
SR Grossman, ME Deato, C Brignone, HM Chan, AL Kung, H Tagami, ...
Science 300 (5617), 342-344, 2003
6252003
H3K79 methylation profiles define murine and human MLL-AF4 leukemias
AV Krivtsov, Z Feng, ME Lemieux, J Faber, S Vempati, AU Sinha, X Xia, ...
Cancer cell 14 (5), 355-368, 2008
6172008
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
AL Kung, SD Zabludoff, DS France, SJ Freedman, EA Tanner, A Vieira, ...
Cancer cell 6 (1), 33-43, 2004
6132004
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