| The interplay between cell signalling and the mevalonate pathway in cancer PJ Mullen, R Yu, J Longo, MC Archer, LZ Penn Nature Reviews Cancer 16 (11), 718-731, 2016 | 547 | 2016 |
| Statins as Anticancer Agents in the Era of Precision Medicine J Longo, JE van Leeuwen, M Elbaz, E Branchard, LZ Penn Clinical Cancer Research 26 (22), 5791-5800, 2020 | 128 | 2020 |
| Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins R Yu, J Longo, JE van Leeuwen, PJ Mullen, W Ba-Alawi, B Haibe-Kains, ... Cancer Research 78 (5), 1347-1357, 2018 | 67 | 2018 |
| An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer J Longo, PJ Mullen, R Yu, JE van Leeuwen, M Masoomian, DTS Woon, ... Molecular Metabolism 25 (7), 119-130, 2019 | 62 | 2019 |
| Carbon source availability drives nutrient utilization in CD8+ T cells I Kaymak, KM Luda, LR Duimstra, EH Ma, J Longo, MS Dahabieh, ... Cell Metabolism 34 (9), 1298-1311. e6, 2022 | 57 | 2022 |
| A pilot window-of-opportunity study of preoperative fluvastatin in localized prostate cancer J Longo, RJ Hamilton, M Masoomian, N Khurram, E Branchard, PJ Mullen, ... Prostate Cancer and Prostatic Diseases 23 (4), 630-637, 2020 | 43 | 2020 |
| Kaiso overexpression promotes intestinal inflammation and potentiates intestinal tumorigenesis in Apc(Min/+) mice CC Pierre, J Longo, M Mavor, SB Milosavljevic, R Chaudhary, E Gilbreath, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1852 (9 …, 2015 | 37 | 2015 |
| Methylation-dependent regulation of hypoxia inducible factor-1 alpha gene expression by the transcription factor Kaiso CC Pierre, J Longo, BI Bassey-Archibong, RM Hallett, S Milosavljevic, ... Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1849 (12 …, 2015 | 35 | 2015 |
| Mevalonate Pathway Inhibition Slows Breast Cancer Metastasis via Reduced N-glycosylation Abundance and Branching R Yu, J Longo, JE van Leeuwen, C Zhang, E Branchard, M Elbaz, ... Cancer Research 81 (10), 2625-2635, 2021 | 28 | 2021 |
| The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma J Longo, P Smirnov, Z Li, E Branchard, JE van Leeuwen, JD Licht, ... Leukemia 35 (3), 796–808, 2021 | 26 | 2021 |
| Modelling the MYC-driven normal-to-tumour switch in breast cancer C Lourenco, M Kalkat, KE Houlahan, J De Melo, J Longo, SJ Done, ... Disease Models & Mechanisms 12 (7), dmm038083, 2019 | 22 | 2019 |
| Cyclic AMP‐hydrolyzing phosphodiesterase inhibitors potentiate statin‐induced cancer cell death J Longo, AA Pandyra, P Stachura, MD Minden, AD Schimmer, LZ Penn Molecular Oncology 14 (10), 2533-2545, 2020 | 17 | 2020 |
| Ketolysis drives CD8+ T cell effector function through effects on histone acetylation KM Luda, J Longo, SM Kitchen-Goosen, LR Duimstra, EH Ma, ... Immunity 56 (9), 2021-2035. e8, 2023 | 16 | 2023 |
| The POZ-ZF transcription factor Znf131 is implicated as a regulator of Kaiso-mediated biological processes SC Robinson, NS Donaldson-Kabwe, A Dvorkin-Gheva, J Longo, L He, ... Biochemical and Biophysical Research Communications 493 (1), 416-421, 2017 | 8 | 2017 |
| Statins and prostate cancer—hype or hope? The biological perspective J Longo, SJ Freedland, LZ Penn, RJ Hamilton Prostate Cancer and Prostatic Diseases 25 (4), 650-656, 2022 | 7 | 2022 |
| Computational pharmacogenomic screen identifies drugs that potentiate the anti-breast cancer activity of statins JE van Leeuwen, W Ba-Alawi, E Branchard, J Cruickshank, W Schormann, ... Nature Communications 13 (1), 6323, 2022 | 7 | 2022 |
| Phase I dose escalation study of concurrent palliative radiation therapy with sorafenib in three anatomical cohorts (Thorax, Abdomen, Pelvis): The TAP study L Murray, J Longo, J Wan, C Chung, L Wang, L Dawson, M Milosevic, ... Radiotherapy and Oncology 124 (1), 74-79, 2017 | 6 | 2017 |
| Ketolysis is a metabolic driver of CD8+ T cell effector function through histone acetylation KM Luda, SM Kitchen-Goosen, EH Ma, MLJ Watson, LR Duimstra, ... bioRxiv, 2022.08. 26.505402, 2022 | 2 | 2022 |
| PYGBacking on glycogen metabolism to fuel early memory T cell recall responses J Longo, MLJ Watson, MJ Vos, KS Williams, RG Jones Molecular Cell 82 (16), 2918-2921, 2022 | 2 | 2022 |
| Computational pharmacogenomics screen identifies synergistic statin-compound combinations as anti-breast cancer therapies J van Leeuwen, W Ba-Alawi, E Branchard, J Longo, J Silvester, ... bioRxiv, 2020.09. 07.286922, 2020 | 2 | 2020 |
Linda Z. PennSenior Scientist, Princess Margaret Cancer Centre, Toronto, Ontario CanadaVerified email at uhnresearch.ca
