| Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice NR Sundaresan, M Gupta, G Kim, SB Rajamohan, A Isbatan, MP Gupta The Journal of clinical investigation 119 (9), 2758-2771, 2009 | 1100 | 2009 |
| SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70 NR Sundaresan, SA Samant, VB Pillai, SB Rajamohan, MP Gupta Molecular and cellular biology 28 (20), 6384-6401, 2008 | 625 | 2008 |
| The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun NR Sundaresan, P Vasudevan, L Zhong, G Kim, S Samant, V Parekh, ... Nature medicine 18 (11), 1643-1650, 2012 | 469 | 2012 |
| Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway VB Pillai, NR Sundaresan, G Kim, M Gupta, SB Rajamohan, JB Pillai, ... Journal of Biological Chemistry 285 (5), 3133-3144, 2010 | 464 | 2010 |
| SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress SA Samant, HJ Zhang, Z Hong, VB Pillai, NR Sundaresan, D Wolfgeher, ... Molecular and cellular biology 34 (5), 807-819, 2014 | 403 | 2014 |
| Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3 VB Pillai, S Samant, NR Sundaresan, H Raghuraman, G Kim, MY Bonner, ... Nature communications 6 (1), 6656, 2015 | 387 | 2015 |
| The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy NR Sundaresan, VB Pillai, D Wolfgeher, S Samant, P Vasudevan, ... Science signaling 4 (182), ra46-ra46, 2011 | 351 | 2011 |
| SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly (ADP-ribose) polymerase 1 SB Rajamohan, VB Pillai, M Gupta, NR Sundaresan, KG Birukov, ... Molecular and cellular biology 29 (15), 4116-4129, 2009 | 346 | 2009 |
| Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy M Sulaiman, MJ Matta, NR Sunderesan, MP Gupta, M Periasamy, ... American Journal of Physiology-Heart and Circulatory Physiology 298 (3 …, 2010 | 328 | 2010 |
| Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging VB Pillai, NR Sundaresan, MP Gupta Circulation research 114 (2), 368-378, 2014 | 269 | 2014 |
| SIRT3 blocks aging-associated tissue fibrosis in mice by deacetylating and activating glycogen synthase kinase 3β NR Sundaresan, S Bindu, VB Pillai, S Samant, Y Pan, JY Huang, M Gupta, ... Molecular and cellular biology 36 (5), 678-692, 2016 | 179 | 2016 |
| A novel cardiomyocyte-enriched microRNA, miR-378, targets insulin-like growth factor 1 receptor: implications in postnatal cardiac remodeling and cell survival I Knezevic, A Patel, NR Sundaresan, MP Gupta, RJ Solaro, ... Journal of Biological Chemistry 287 (16), 12913-12926, 2012 | 168 | 2012 |
| Mitochondrial SIRT3 and heart disease VB Pillai, NR Sundaresan, V Jeevanandam, MP Gupta Cardiovascular research 88 (2), 250-256, 2010 | 157 | 2010 |
| Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy NR Sundaresan, VB Pillai, MP Gupta Journal of molecular and cellular cardiology 51 (4), 614-618, 2011 | 131 | 2011 |
| SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer M Ming, W Han, B Zhao, NR Sundaresan, CX Deng, MP Gupta, YY He Cancer research 74 (20), 5925-5933, 2014 | 129 | 2014 |
| Subcutaneous Ehrlich Ascites Carcinoma mice model for studying cancer-induced cardiomyopathy S Mishra, AK Tamta, M Sarikhani, PA Desingu, SM Kizkekra, AS Pandit, ... Scientific reports 8 (1), 5599, 2018 | 125 | 2018 |
| A cardiac-enriched microRNA, miR-378, blocks cardiac hypertrophy by targeting Ras signaling RS Nagalingam, NR Sundaresan, MP Gupta, DL Geenen, RJ Solaro, ... Journal of Biological Chemistry 288 (16), 11216-11232, 2013 | 104 | 2013 |
| Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling VB Pillai, NR Sundaresan, G Kim, S Samant, L Moreno-Vinasco, ... American Journal of Physiology-Heart and Circulatory Physiology 304 (3 …, 2013 | 93 | 2013 |
| Defective Nrf2-dependent redox signalling contributes to microvascular dysfunction in type 2 diabetes GV Velmurugan, NR Sundaresan, MP Gupta, C White Cardiovascular research 100 (1), 143-150, 2013 | 87 | 2013 |
| Diabetes induces fibrotic changes in the lung through the activation of TGF-β signaling pathways G Talakatta, M Sarikhani, J Muhamed, K Dhanya, BS Somashekar, ... Scientific reports 8 (1), 11920, 2018 | 77 | 2018 |
Mahesh P. GuptaAssociate Professor and Director of Cardiothoracic Center Research Program, University of ChicagoVerified email at surgery.bsd.uchicago.edu
