| The GM–CSF/IL‐3/IL‐5 cytokine receptor family: from ligand recognition to initiation of signaling SE Broughton, U Dhagat, TR Hercus, TL Nero, MA Grimbaldeston, ... Immunological reviews 250 (1), 277-302, 2012 | 248 | 2012 |
| Signalling by the βc family of cytokines TR Hercus, U Dhagat, WLT Kan, SE Broughton, TL Nero, M Perugini, ... Cytokine & growth factor reviews 24 (3), 189-201, 2013 | 101 | 2013 |
| The βc receptor family–Structural insights and their functional implications SE Broughton, TL Nero, U Dhagat, WL Kan, TR Hercus, D Tvorogov, ... Cytokine 74 (2), 247-258, 2015 | 83 | 2015 |
| Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody SE Broughton, TR Hercus, MP Hardy, BJ McClure, TL Nero, M Dottore, ... Cell reports 8 (2), 410-419, 2014 | 55 | 2014 |
| Conformational changes in the GM-CSF receptor suggest a molecular mechanism for affinity conversion and receptor signaling SE Broughton, TR Hercus, TL Nero, M Dottore, BJ McClure, U Dhagat, ... Structure 24 (8), 1271-1281, 2016 | 46 | 2016 |
| CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors C Panousis, U Dhagat, KM Edwards, V Rayzman, MP Hardy, H Braley, ... MAbs 8 (3), 436-453, 2016 | 46 | 2016 |
| Inhibitors of human 20α-hydroxysteroid dehydrogenase (AKR1C1) O El-Kabbani, U Dhagat, A Hara The Journal of steroid biochemistry and molecular biology 125 (1-2), 105-111, 2011 | 46 | 2011 |
| Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20α-hydroxysteroid … O El-Kabbani, PJ Scammells, J Gosling, U Dhagat, S Endo, T Matsunaga, ... Journal of medicinal chemistry 52 (10), 3259-3264, 2009 | 44 | 2009 |
| Role of the β Common (βc) Family of Cytokines in Health and Disease TR Hercus, WLT Kan, SE Broughton, D Tvorogov, HS Ramshaw, ... Cold Spring Harbor Perspectives in Biology 10 (6), a028514, 2018 | 41 | 2018 |
| A salicylic acid-based analogue discovered from virtual screening as a potent inhibitor of human 20α-hydroxysteroid dehydrogenase U Dhagat, V Carbone, RPT Chung, T Matsunaga, S Endo, A Hara, ... Medicinal Chemistry 3 (6), 546-550, 2007 | 35 | 2007 |
| A dual role for the N-terminal domain of the IL-3 receptor in cell signalling SE Broughton, TR Hercus, TL Nero, WL Kan, EF Barry, M Dottore, ... Nature communications 9 (1), 386, 2018 | 33 | 2018 |
| CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins CG Langendorf, MT O'Brien, KRW Ngoei, LM McAloon, U Dhagat, ... Journal of Biological Chemistry 295 (48), 16239-16250, 2020 | 30 | 2020 |
| EPO does not promote interaction between the erythropoietin and beta-common receptors KS Cheung Tung Shing, SE Broughton, TL Nero, K Gillinder, MD Ilsley, ... Scientific reports 8 (1), 12457, 2018 | 29 | 2018 |
| Selectivity determinants of inhibitor binding to human 20α-hydroxysteroid dehydrogenase: Crystal structure of the enzyme in ternary complex with coenzyme and the potent … U Dhagat, S Endo, R Sumii, A Hara, O El-Kabbani Journal of medicinal chemistry 51 (15), 4844-4848, 2008 | 27 | 2008 |
| Molecular determinants for the stereospecific reduction of 3-ketosteroids and reactivity towards all-trans-retinal of a short-chain dehydrogenase/reductase (DHRS4) S Endo, S Maeda, T Matsunaga, U Dhagat, O El-Kabbani, N Tanaka, ... Archives of biochemistry and biophysics 481 (2), 183-190, 2009 | 24 | 2009 |
| Structure-based optimization and biological evaluation of human 20α-hydroxysteroid dehydrogenase (AKR1C1) salicylic acid-based inhibitors O El-Kabbani, PJ Scammells, T Day, U Dhagat, S Endo, T Matsunaga, ... European journal of medicinal chemistry 45 (11), 5309-5317, 2010 | 19 | 2010 |
| Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362 SE Broughton, TR Hercus, TL Nero, U Dhagat, CM Owczarek, MP Hardy, ... Acta Crystallographica Section F: Structural Biology Communications 70 (3 …, 2014 | 13 | 2014 |
| Probing the inhibitor selectivity pocket of human 20α-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis O El-Kabbani, U Dhagat, M Soda, S Endo, T Matsunaga, A Hara Bioorganic & medicinal chemistry letters 21 (8), 2564-2567, 2011 | 13 | 2011 |
| Inhibition of 3 (17) α-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors U Dhagat, S Endo, A Hara, O El-Kabbani Bioorganic & medicinal chemistry 16 (6), 3245-3254, 2008 | 13 | 2008 |
| Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesis K Sundaram, U Dhagat, S Endo, R Chung, T Matsunaga, A Hara, ... Bioorganic & medicinal chemistry letters 21 (2), 801-804, 2011 | 11 | 2011 |
