| Evasion of the innate immune response: the Old World alphavirus nsP2 protein induces rapid degradation of Rpb1, a catalytic subunit of RNA polymerase II I Akhrymuk, SV Kulemzin, EI Frolova Journal of virology 86 (13), 7180-7191, 2012 | 244 | 2012 |
| New World and Old World alphaviruses have evolved to exploit different components of stress granules, FXR and G3BP proteins, for assembly of viral replication complexes DY Kim, JM Reynaud, A Rasalouskaya, I Akhrymuk, JA Mobley, I Frolov, ... PLoS pathogens 12 (8), e1005810, 2016 | 160 | 2016 |
| Alpha 1 antitrypsin is an inhibitor of the SARS-CoV-2–priming protease TMPRSS2 NP Azouz, AM Klingler, V Callahan, IV Akhrymuk, K Elez, L Raich, ... Pathogens And Immunity 6 (1), 55, 2021 | 106 | 2021 |
| The pro-inflammatory chemokines CXCL9, CXCL10 and CXCL11 are upregulated following SARS-CoV-2 infection in an AKT-dependent manner V Callahan, S Hawks, MA Crawford, CW Lehman, HA Morrison, ... Viruses 13 (6), 1062, 2021 | 104 | 2021 |
| Hypervariable domains of nsP3 proteins of New World and Old World alphaviruses mediate formation of distinct, virus-specific protein complexes NJ Foy, M Akhrymuk, I Akhrymuk, S Atasheva, A Bopda-Waffo, I Frolov, ... Journal of virology 87 (4), 1997-2010, 2013 | 89 | 2013 |
| Both RIG-I and MDA5 detect alphavirus replication in concentration-dependent mode I Akhrymuk, I Frolov, EI Frolova Virology 487, 230-241, 2016 | 78 | 2016 |
| Early events in alphavirus replication determine the outcome of infection I Frolov, M Akhrymuk, I Akhrymuk, S Atasheva, EI Frolova Journal of virology 86 (9), 5055-5066, 2012 | 66 | 2012 |
| Sindbis virus infection causes cell death by nsP2-induced transcriptional shutoff or by nsP3-dependent translational shutoff I Akhrymuk, I Frolov, EI Frolova Journal of virology 92 (23), 10.1128/jvi. 01388-18, 2018 | 54 | 2018 |
| Novel mutations in nsP2 abolish chikungunya virus-induced transcriptional shutoff and make the virus less cytopathic without affecting its replication rates I Akhrymuk, T Lukash, I Frolov, EI Frolova Journal of virology 93 (4), 10.1128/jvi. 02062-18, 2019 | 49 | 2019 |
| PSGL-1 inhibits the incorporation of SARS-CoV and SARS-CoV-2 Spike glycoproteins into pseudovirions and impairs pseudovirus attachment and infectivity S He, AA Waheed, B Hetrick, D Dabbagh, IV Akhrymuk, K Kehn-Hall, ... Viruses 13 (1), 46, 2020 | 20 | 2020 |
| Hydrogel particles improve detection of SARS-CoV-2 RNA from multiple sample types RA Barclay, I Akhrymuk, A Patnaik, V Callahan, C Lehman, P Andersen, ... Scientific Reports 10 (1), 22425, 2020 | 17 | 2020 |
| Lack of nsP2-specific nuclear functions attenuates chikungunya virus replication both in vitro and in vivo CD Meshram, T Lukash, AT Phillips, I Akhrymuk, EI Frolova, I Frolov Virology 534, 14-24, 2019 | 17 | 2019 |
| Atractylodin suppresses TGF-β-mediated epithelial-mesenchymal transition in alveolar epithelial cells and attenuates bleomycin-induced pulmonary fibrosis in mice KW Chang, X Zhang, SC Lin, YC Lin, CH Li, I Akhrymuk, SH Lin, CC Lin International Journal of Molecular Sciences 22 (20), 11152, 2021 | 14 | 2021 |
| Magnetic nanotrap particles preserve the stability of Venezuelan equine encephalitis virus in blood for laboratory detection I Akhrymuk, SC Lin, M Sun, A Patnaik, C Lehman, L Altamura, T Minogue, ... Frontiers in Veterinary Science 6, 509, 2020 | 13 | 2020 |
| Protein Kinase C subtype δ interacts with Venezuelan equine encephalitis virus capsid protein and regulates viral RNA binding through modulation of capsid phosphorylation BD Carey, I Akhrymuk, B Dahal, CL Pinkham, N Bracci, S Finstuen-Magro, ... PLoS Pathogens 16 (3), e1008282, 2020 | 11 | 2020 |
| Proteomic discovery of veev e2-host partner interactions identifies grp78 inhibitor ha15 as a potential therapeutic for alphavirus infections MD Barrera, V Callahan, I Akhrymuk, N Bhalla, W Zhou, C Campbell, ... Pathogens 10 (3), 283, 2021 | 10 | 2021 |
| RK-33, a small molecule inhibitor of host RNA helicase DDX3, suppresses multiple variants of SARS-CoV-2 F Vesuna, I Akhrymuk, A Smith, PT Winnard Jr, SC Lin, L Panny, ... Frontiers in Microbiology 13, 959577, 2022 | 9 | 2022 |
| Alphavirus and compositions, methods, and kits related thereto KW Kehn-Hall, BD Carey, IV Akhrymuk, CW Lehman US Patent 11,406,699, 2022 | 9 | 2022 |
| PERK is critical for alphavirus nonstructural protein translation B Dahal, CW Lehman, I Akhrymuk, NR Bracci, L Panny, MD Barrera, ... Viruses 13 (5), 892, 2021 | 7 | 2021 |
| PSGL-1 blocks SARS-CoV-2 S protein-mediated virus attachment and infection of target cells S He, B Hetrick, D Dabbagh, IV Akhrymuk, K Kehn-Hall, EO Freed, Y Wu bioRxiv, 2020 | 6* | 2020 |
