Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease SP Yun, TI Kam, N Panicker, SM Kim, Y Oh, JS Park, SH Kwon, YJ Park, ... Nature medicine 24 (7), 931-938, 2018 | 853 | 2018 |
Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3 X Mao, MT Ou, SS Karuppagounder, TI Kam, X Yin, Y Xiong, P Ge, ... Science 353 (6307), aah3374, 2016 | 676 | 2016 |
Induction of glial fibrillary acidic protein expression in astrocytes by nitric oxide S Brahmachari, YK Fung, K Pahan Journal of Neuroscience 26 (18), 4930-4939, 2006 | 424 | 2006 |
Poly (ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease TI Kam, X Mao, H Park, SC Chou, SS Karuppagounder, GE Umanah, ... Science 362 (6414), eaat8407, 2018 | 394 | 2018 |
The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease SS Karuppagounder, S Brahmachari, Y Lee, VL Dawson, TM Dawson, ... Scientific reports 4 (1), 4874, 2014 | 244 | 2014 |
Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease A Ghosh, A Roy, J Matras, S Brahmachari, HE Gendelman, K Pahan Journal of Neuroscience 29 (43), 13543-13556, 2009 | 201 | 2009 |
Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses S Brahmachari, A Jana, K Pahan The Journal of Immunology 183 (9), 5917-5927, 2009 | 186 | 2009 |
PINK1 primes Parkin-mediated ubiquitination of PARIS in dopaminergic neuronal survival Y Lee, DA Stevens, SU Kang, H Jiang, YI Lee, HS Ko, LA Scarffe, ... Cell reports 18 (4), 918-932, 2017 | 180 | 2017 |
Activation of tyrosine kinase c-Abl contributes to α-synuclein–induced neurodegeneration S Brahmachari, P Ge, SH Lee, D Kim, SS Karuppagounder, M Kumar, ... The Journal of clinical investigation 126 (8), 2970-2988, 2016 | 165 | 2016 |
Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson’s disease A Roy, A Ghosh, A Jana, X Liu, S Brahmachari, HE Gendelman, K Pahan PloS one 7 (6), e38113, 2012 | 138 | 2012 |
TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson’s disease via CNTF JH Nam, ES Park, SY Won, YA Lee, KI Kim, JY Jeong, JY Baek, EJ Cho, ... Brain 138 (12), 3610-3622, 2015 | 116 | 2015 |
Cinnamon and Its Metabolite Sodium Benzoate Attenuate the Activation of p21rac and Protect Memory and Learning in an Animal Model of Alzheimer’s Disease KK Modi, A Roy, S Brahmachari, SB Rangasamy, K Pahan PloS one 10 (6), e0130398, 2015 | 108 | 2015 |
Sodium benzoate, a food additive and a metabolite of cinnamon, modifies T cells at multiple steps and inhibits adoptive transfer of experimental allergic encephalomyelitis S Brahmachari, K Pahan The Journal of Immunology 179 (1), 275-283, 2007 | 102 | 2007 |
Efficacy of nilotinib in patients with moderately advanced Parkinson disease: a randomized clinical trial T Simuni, B Fiske, K Merchant, CS Coffey, E Klingner, C Caspell-Garcia, ... JAMA neurology 78 (3), 312-320, 2021 | 95 | 2021 |
c-Abl and Parkinson’s disease: mechanisms and therapeutic potential S Brahmachari, SS Karuppagounder, P Ge, S Lee, VL Dawson, ... Journal of Parkinson's Disease 7 (4), 589-601, 2017 | 83 | 2017 |
Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease N Panicker, TI Kam, H Wang, S Neifert, SC Chou, M Kumar, ... Neuron 110 (15), 2422-2437. e9, 2022 | 82 | 2022 |
STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy JT Hinkle, J Patel, N Panicker, SS Karuppagounder, D Biswas, ... Proceedings of the National Academy of Sciences 119 (15), e2118819119, 2022 | 80 | 2022 |
Suppression of regulatory T cells by IL-12p40 homodimer via nitric oxide S Brahmachari, K Pahan The Journal of Immunology 183 (3), 2045-2058, 2009 | 60 | 2009 |
LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-mediated neurotoxicity SS Karuppagounder, Y Xiong, Y Lee, MC Lawless, D Kim, E Nordquist, ... Journal of chemical neuroanatomy 76, 90-97, 2016 | 53 | 2016 |
Defects in mitochondrial biogenesis drive mitochondrial alterations in PARKIN-deficient human dopamine neurons M Kumar, J Acevedo-Cintrón, A Jhaldiyal, H Wang, SA Andrabi, S Eacker, ... Stem Cell Reports 15 (3), 629-645, 2020 | 51 | 2020 |