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Saurav Brahmachari
Saurav Brahmachari
Senior Scientist, Valted Seq Inc, Gaithersburg, MD
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Year
Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease
SP Yun, TI Kam, N Panicker, SM Kim, Y Oh, JS Park, SH Kwon, YJ Park, ...
Nature medicine 24 (7), 931-938, 2018
8532018
Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3
X Mao, MT Ou, SS Karuppagounder, TI Kam, X Yin, Y Xiong, P Ge, ...
Science 353 (6307), aah3374, 2016
6762016
Induction of glial fibrillary acidic protein expression in astrocytes by nitric oxide
S Brahmachari, YK Fung, K Pahan
Journal of Neuroscience 26 (18), 4930-4939, 2006
4242006
Poly (ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease
TI Kam, X Mao, H Park, SC Chou, SS Karuppagounder, GE Umanah, ...
Science 362 (6414), eaat8407, 2018
3942018
The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease
SS Karuppagounder, S Brahmachari, Y Lee, VL Dawson, TM Dawson, ...
Scientific reports 4 (1), 4874, 2014
2442014
Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease
A Ghosh, A Roy, J Matras, S Brahmachari, HE Gendelman, K Pahan
Journal of Neuroscience 29 (43), 13543-13556, 2009
2012009
Sodium benzoate, a metabolite of cinnamon and a food additive, reduces microglial and astroglial inflammatory responses
S Brahmachari, A Jana, K Pahan
The Journal of Immunology 183 (9), 5917-5927, 2009
1862009
PINK1 primes Parkin-mediated ubiquitination of PARIS in dopaminergic neuronal survival
Y Lee, DA Stevens, SU Kang, H Jiang, YI Lee, HS Ko, LA Scarffe, ...
Cell reports 18 (4), 918-932, 2017
1802017
Activation of tyrosine kinase c-Abl contributes to α-synuclein–induced neurodegeneration
S Brahmachari, P Ge, SH Lee, D Kim, SS Karuppagounder, M Kumar, ...
The Journal of clinical investigation 126 (8), 2970-2988, 2016
1652016
Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson’s disease
A Roy, A Ghosh, A Jana, X Liu, S Brahmachari, HE Gendelman, K Pahan
PloS one 7 (6), e38113, 2012
1382012
TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson’s disease via CNTF
JH Nam, ES Park, SY Won, YA Lee, KI Kim, JY Jeong, JY Baek, EJ Cho, ...
Brain 138 (12), 3610-3622, 2015
1162015
Cinnamon and Its Metabolite Sodium Benzoate Attenuate the Activation of p21rac and Protect Memory and Learning in an Animal Model of Alzheimer’s Disease
KK Modi, A Roy, S Brahmachari, SB Rangasamy, K Pahan
PloS one 10 (6), e0130398, 2015
1082015
Sodium benzoate, a food additive and a metabolite of cinnamon, modifies T cells at multiple steps and inhibits adoptive transfer of experimental allergic encephalomyelitis
S Brahmachari, K Pahan
The Journal of Immunology 179 (1), 275-283, 2007
1022007
Efficacy of nilotinib in patients with moderately advanced Parkinson disease: a randomized clinical trial
T Simuni, B Fiske, K Merchant, CS Coffey, E Klingner, C Caspell-Garcia, ...
JAMA neurology 78 (3), 312-320, 2021
952021
c-Abl and Parkinson’s disease: mechanisms and therapeutic potential
S Brahmachari, SS Karuppagounder, P Ge, S Lee, VL Dawson, ...
Journal of Parkinson's Disease 7 (4), 589-601, 2017
832017
Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease
N Panicker, TI Kam, H Wang, S Neifert, SC Chou, M Kumar, ...
Neuron 110 (15), 2422-2437. e9, 2022
822022
STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy
JT Hinkle, J Patel, N Panicker, SS Karuppagounder, D Biswas, ...
Proceedings of the National Academy of Sciences 119 (15), e2118819119, 2022
802022
Suppression of regulatory T cells by IL-12p40 homodimer via nitric oxide
S Brahmachari, K Pahan
The Journal of Immunology 183 (3), 2045-2058, 2009
602009
LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-mediated neurotoxicity
SS Karuppagounder, Y Xiong, Y Lee, MC Lawless, D Kim, E Nordquist, ...
Journal of chemical neuroanatomy 76, 90-97, 2016
532016
Defects in mitochondrial biogenesis drive mitochondrial alterations in PARKIN-deficient human dopamine neurons
M Kumar, J Acevedo-Cintrón, A Jhaldiyal, H Wang, SA Andrabi, S Eacker, ...
Stem Cell Reports 15 (3), 629-645, 2020
512020
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