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Ian R Macdonald
Ian R Macdonald
Verified email at dal.ca
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Comparison of the binding of reversible inhibitors to human butyrylcholinesterase and acetylcholinesterase: A crystallographic, kinetic and calorimetric study
TL Rosenberry, X Brazzolotto, IR Macdonald, M Wandhammer, ...
Molecules 22 (12), 2098, 2017
2222017
Early detection of cerebral glucose uptake changes in the 5XFAD mouse
IR Macdonald, DR DeBay, GA Reid, TP O’leary, CT Jollymore, G Mawko, ...
Current Alzheimer Research 11 (5), 450-460, 2014
852014
Cholinesterase inhibition in Alzheimer's disease: is specificity the answer?
IR Macdonald, K Rockwood, E Martin, S Darvesh
Journal of Alzheimer's Disease 42 (2), 379-384, 2014
852014
Quantification of butyrylcholinesterase activity as a sensitive and specific biomarker of Alzheimer’s disease
IR Macdonald, SP Maxwell, GA Reid, MK Cash, DR DeBay, S Darvesh
Journal of Alzheimer's Disease 58 (2), 491-505, 2017
782017
Probing the peripheral site of human butyrylcholinesterase
IR Macdonald, E Martin, TL Rosenberry, S Darvesh
Biochemistry 51 (36), 7046-7053, 2012
712012
Butyrylcholinesterase activity in multiple sclerosis neuropathology
S Darvesh, AM LeBlanc, IR Macdonald, GA Reid, V Bhan, RJ Macaulay, ...
Chemico-biological interactions 187 (1-3), 425-431, 2010
552010
Butyrylcholinesterase-knockout reduces fibrillar β-amyloid and conserves 18FDG retention in 5XFAD mouse model of Alzheimer’s disease
DR DeBay, GA Reid, IR Macdonald, G Mawko, S Burrell, E Martin, ...
Brain research 1671, 102-110, 2017
362017
Selectivity of phenothiazine cholinesterase inhibitors for neurotransmitter systems
S Darvesh, IR Macdonald, E Martin
Bioorganic & medicinal chemistry letters 23 (13), 3822-3825, 2013
222013
Synthesis and preliminary evaluation of phenyl 4-123I-iodophenylcarbamate for visualization of cholinesterases associated with Alzheimer disease pathology
IR Macdonald, GA Reid, IR Pottie, E Martin, S Darvesh
Journal of Nuclear Medicine 57 (2), 297-302, 2016
152016
Cysteine thioesters as myelin proteolipid protein analogues to examine the role of butyrylcholinesterase in myelin decompaction
IR Pottie, EA Higgins, RA Blackman, IR Macdonald, E Martin, S Darvesh
ACS Chemical Neuroscience 2 (3), 151-159, 2011
152011
Delayed parent artery occlusions following use of Silk flow diverters for treatment of intracranial aneurysms
IR Macdonald, JJS Shankar
Journal of NeuroInterventional Surgery 11 (7), 690-693, 2019
112019
Synthesis and preliminary evaluation of piperidinyl and pyrrolidinyl iodobenzoates as imaging agents for butyrylcholinesterase
IR Macdonald, GA Reid, EE Joy, IR Pottie, G Matte, S Burrell, G Mawko, ...
Molecular imaging and biology 13, 1250-1261, 2011
102011
Thioesters for the in vitro evaluation of agents to image brain cholinesterases
IR Macdonald, CT Jollymore, GA Reid, IR Pottie, E Martin, S Darvesh
Journal of Enzyme Inhibition and Medicinal Chemistry 28 (3), 447-455, 2013
42013
Standardized approach to direct first pass aspiration technique for endovascular thrombectomy: Description and initial experience with CANADAPT
IR Macdonald, V Linehan, B Sneek, D Volders
Interventional Neuroradiology, 15910199241230360, 2024
22024
Practical use and underlying physics of the BENCHMARK™ BMX™ 96 for large-bore aspiration thrombectomy: Case report of initial institutional experience
IR Macdonald, EA Cora, I Grant, D Volders
The Neuroradiology Journal 35 (2), 250-254, 2022
22022
Butyrylcholinesterase ligands as diagnostic tools and treatment for diseases of the nervous system
S Darvesh, E Joy, E Martin, I MacDonald, I Pottie
US Patent 8,795,630, 2014
12014
IC-P-045 CEREBRAL GLUCOSE METABOLISM, PATHOLOGY AND BEHAVIOR IN THE 5XFAD MOUSE MODEL OF ALZHEIMER’S DISEASE
I Macdonald, A Reid, I Pottie, E Martin, S Darvesh
Alzheimer's & Dementia 9, P32-P32, 2013
12013
IC-P-051 SYNTHESIS AND EVALUATION OF BUTYRYLCHOLINESTERASE LIGANDS FOR NEUROIMAGING ALZHEIMER’S DISEASE
I Macdonald, I Pottie, EE Joy, G Matte, S Burrell, G Mawko, E Martin, ...
Alzheimer's & Dementia 6, S23-S23, 2010
12010
The importance of arterial systolic pressure (Push) in successful first pass aspiration technique for endovascular thrombectomy.
D Volders, V Linehan, IR Macdonald
Journal of Neuroradiology= Journal de Neuroradiologie, S0150-9861 (24) 00123, 2024
2024
Evaluation of Patients with Cranial Nerve Disorders
JW Casselman, A Krainik, I Macdonald
Diseases of the Brain, Head and Neck, Spine 2024-2027: Diagnostic Imaging …, 2024
2024
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