The penicillin gene cluster is amplified in tandem repeats linked by conserved hexanucleotide sequences. F Fierro, JL Barredo, B Diez, S Gutierrez, FJ Fernandez, JF Martin Proceedings of the National Academy of Sciences 92 (13), 6200-6204, 1995 | 226 | 1995 |
Filamentous fungi from extreme environments as a promising source of novel bioactive secondary metabolites R Chávez, F Fierro, RO García-Rico, I Vaca Frontiers in Microbiology 6, 903, 2015 | 113 | 2015 |
Production of penicillin by fungi growing on food products: identification of a complete penicillin gene cluster in Penicillium griseofulvum and a truncated cluster in … F Laich, F Fierro, JF Martín Applied and environmental microbiology 68 (3), 1211-1219, 2002 | 111 | 2002 |
Resolution of four large chromosomes in penicillin-producing filamentous fungi: the penicillin gene cluster is located on chromosome II (9.6 Mb) in Penicillium notatum and … F Fierro, S Gutiérrez, B Diez, JF Martín Molecular and General Genetics MGG 241, 573-578, 1993 | 107 | 1993 |
Expression of the cefG gene is limiting for cephalosporin biosynthesis in Acremonium chrysogenum S Gutiérrez, J Velasco, AT Marcos, FJ Fernández, F Fierro, JL Barredo, ... Applied microbiology and biotechnology 48, 606-614, 1997 | 100 | 1997 |
Gene organization and plasticity of the β-lactam genes in different filamentous fungi S Gutiérrez, F Fierro, J Casqueiro, JF Martín Antonie Van Leeuwenhoek 75, 81-94, 1999 | 94 | 1999 |
Mutants blocked in penicillin biosynthesis show a deletion of the entire penicillin gene cluster at a specific site within a conserved hexanucleotide sequence F Fierro, E Montenegro, S Gutiérrez, JF Martín Applied microbiology and biotechnology 44, 597-604, 1996 | 92 | 1996 |
Transcriptional and bioinformatic analysis of the 56.8 kb DNA region amplified in tandem repeats containing the penicillin gene cluster in Penicillium chrysogenum F Fierro, C García-Estrada, NI Castillo, R Rodríguez, T Velasco-Conde, ... Fungal Genetics and Biology 43 (9), 618-629, 2006 | 79 | 2006 |
Molecular mechanisms of chromosomal rearrangement in fungi F Fierro, JF Martín Critical reviews in microbiology 25 (1), 1-17, 1999 | 72 | 1999 |
Autonomously replicating plasmids carrying theAMA1 region inPenicillium chrysogenum F Fierro, K Kosalková, S Gutiérrez, JF Martín Current genetics 29, 482-489, 1996 | 70 | 1996 |
Organization of the Gene Cluster for Biosynthesis of Penicillin in Penicillium nalgiovense and Antibiotic Production in Cured Dry Sausages F Laich, F Fierro, RE Cardoza, JF Martin Applied and environmental microbiology 65 (3), 1236-1240, 1999 | 66 | 1999 |
Silencing of the Aspergillopepsin B (pepB) Gene of Aspergillus awamori by Antisense RNA Expression or Protease Removal by Gene Disruption Results in a … FJ Moralejo, RE Cardoza, S Gutierrez, M Lombrana, F Fierro, JF Martín Applied and environmental microbiology 68 (7), 3550-3559, 2002 | 64 | 2002 |
Biochemical characterization and molecular genetics of nine mutants of Penicillium chrysogenum impaired in penicillin biosynthesis. JM Cantoral, S Gutiérrez, F Fierro, S Gil-Espinosa, H Van Liempt, ... Journal of Biological Chemistry 268 (1), 737-744, 1993 | 62 | 1993 |
Direct involvement of the CreA transcription factor in penicillin biosynthesis and expression of the pcbAB gene in Penicillium chrysogenum C Cepeda-García, R Domínguez-Santos, RO García-Rico, ... Applied microbiology and biotechnology 98, 7113-7124, 2014 | 60 | 2014 |
High efficiency transformation of Penicillium nalgiovense with integrative and autonomously replicating plasmids F Fierro, F Laich, RO Garcı́a-Rico, JF Martı́n International Journal of Food Microbiology 90 (2), 237-248, 2004 | 58 | 2004 |
Characterization of the lys2 gene of Penicillium chrysogenum encoding α-aminoadipic acid reductase J Casqueiro, S Gutiérrez, O Banuelos, F Fierro, J Velasco, JF Martín Molecular and General Genetics MGG 259 (5), 549-556, 1998 | 57 | 1998 |
The heterotrimeric Gα protein Pga1 regulates biosynthesis of penicillin, chrysogenin and roquefortine in Penicillium chrysogenum RO García-Rico, F Fierro, E Mauriz, A Gomez, MÁ Fernández-Bodega, ... Microbiology 154 (11), 3567-3578, 2008 | 53 | 2008 |
Reactive oxygen species regulate lovastatin biosynthesis in Aspergillus terreus during submerged and solid-state fermentations RU Miranda, LE Gómez-Quiroz, M Mendoza, A Pérez-Sánchez, F Fierro, ... Fungal biology 118 (12), 979-989, 2014 | 52 | 2014 |
Electroforesis de ADN FF Fierro Herramientas moleculares aplicadas en ecología: aspectos teóricos y prácticos 27, 2014 | 47 | 2014 |
Resolution of chromosomes III and VI of Aspergillus nidulans by pulsed-field gel electrophoresis shows that the penicillin biosynthetic pathway genes pcbAB, pcbC, and penDE are … E Montenegro, F Fierro, FJ Fernandez, S Gutiérrez, JF Martín Journal of bacteriology 174 (21), 7063-7067, 1992 | 47 | 1992 |