Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death E Britti, J Ros, N Esteras, AY Abramov Cell Calcium 86, 102150, 2020 | 69 | 2020 |
Frataxin‐deficient neurons and mice models of Friedreich ataxia are improved by TAT‐MTS cs‐FXN treatment E Britti, F Delaspre, A Feldman, M Osborne, H Greif, J Tamarit, J Ros Journal of cellular and molecular medicine 22 (2), 834-848, 2018 | 46 | 2018 |
Mitochondrial calcium signalling and neurodegenerative diseases E Britti, F Delaspre, J Tamarit, J Ros Neuronal Signaling 2 (4), NS20180061, 2018 | 39 | 2018 |
Mitochondrial pore opening and loss of Ca2+ exchanger NCLX levels occur after frataxin depletion. R Purroy, E Britti, F Delaspre, J Tamarit, J Ros Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018 | 38 | 2018 |
PPAR gamma agonist leriglitazone improves frataxin-loss impairments in cellular and animal models of Friedreich Ataxia L Rodríguez-Pascau, E Britti, P Calap-Quintana, YN Dong, C Vergara, ... Neurobiology of Disease 148, 105162, 2021 | 37 | 2021 |
Calpain-Inhibitors Protect Frataxin-Deficient Dorsal Root Ganglia Neurons from Loss of Mitochondrial Na+/Ca2+ Exchanger, NCLX, and Apoptosis. E Britti, F Delaspre, J Tamarit, J Ros Neurochemical Research, 2020 | 17 | 2020 |
Calcitriol increases frataxin levels and restores mitochondrial function in cell models of Friedreich Ataxia E Britti, F Delaspre, A Sanz-Alcázar, M Medina-Carbonero, M Llovera, ... Biochemical Journal 478 (1), 1-20, 2021 | 13 | 2021 |
Mitochondrial iron and calcium homeostasis in Friedreich ataxia J Tamarit, E Britti, F Delaspre, M Medina‐Carbonero, A Sanz‐Alcázar, ... IUBMB life 73 (3), 543-553, 2021 | 10 | 2021 |
Mice harboring the FXN I151F pathological point mutation present decreased frataxin levels, a Friedreich ataxia-like phenotype, and mitochondrial alterations M Medina-Carbonero, A Sanz-Alcázar, E Britti, F Delaspre, E Cabiscol, ... Cellular and Molecular Life Sciences 79 (2), 74, 2022 | 7 | 2022 |
MIN102 (leriglitazone), a brain penetrant PPAR gamma agonist for the treatment of Friedreich’s ataxia (4147) S Poli, L Rodríguez-Pascau, E Britti, J Ros, P González-Cab, D Lynch, ... Neurology 94 (15 Supplement), 2020 | 3 | 2020 |
Deficient mitochondrial respiration impairs sirtuin activity in dorsal root ganglia in Friedreich Ataxia mouse and cell models A Sanz-Alcázar, E Britti, F Delaspre, M Medina-Carbonero, M Pazos-Gil, ... bioRxiv, 2023.02. 01.526688, 2023 | 1 | 2023 |
Mitochondrial impairment, decreased sirtuin activity and protein acetylation in dorsal root ganglia in Friedreich Ataxia models A Sanz-Alcázar, E Britti, F Delaspre, M Medina-Carbonero, M Pazos-Gil, ... Cellular and Molecular Life Sciences 81 (1), 12, 2024 | | 2024 |
Mitochondrial dysfunction and redox alterations in cellular models and the I151F mouse model of Friedreich Ataxia: role of Sirt3 A Sanz-Alcazar, E Britti, F Delaspre, M Medina-Carbonero, M Pazos-Gil, ... FEBS OPEN BIO 12, 130-130, 2022 | | 2022 |
Mice harboring the FXN I151F point mutation present decreased frataxin levels, a Friedreich Ataxia-like phenotype and mitochondrial alterations M Medina-Carbonero, A Sanz-Alcazar, M Pazos-Gil, E Britti, F Delaspre, ... FEBS OPEN BIO 12, 120-120, 2022 | | 2022 |
Biochemical alterations precede neurobehavioral deficits in a novel mouse model of Friedreich ataxia M Medina-Carbonero, A Sanz-Alcázar, E Britti, F Delaspre, E Cabiscol, ... bioRxiv, 2021.04. 05.438486, 2021 | | 2021 |
Dorsal Root Ganglion neurons as a model of Friedreich Ataxia: cellular alterations and therapeutic approaches E Britti Universitat de Lleida, 2021 | | 2021 |
A translational approach to determine target concentrations of MIN-102 (leriglitazone) to support a Phase II study in Friedreich's ataxia S Poli, L Rodriguez-Pascau, J Ros, P Gonzalez-Cabo, E Britti, D Lynch, ... MOVEMENT DISORDERS 35, S572-S572, 2020 | | 2020 |
Calcitriol increases frataxin levels and restores altered markers in cell models of Friedreich Ataxia E Britti, F Delaspre, M Medina-Carbonero, A Sanz, M Llovera, R Purroy, ... BioRxiv - Preprint, 2020 | | 2020 |
Mitochondrial Calcium Deregulation in Tau K18-Treated Cortical Neurons and Astrocytes E Britti, NE Gallego, J Ros, AY Abramov Biophysical Journal 116 (3), 270a-271a, 2019 | | 2019 |